Preparation and characterization of novel pH‐sensitive binary grafted polymeric blends of gelatin and poly(vinyl alcohol): Water sorption and blood compatibility study

Bajpai, A. K.; Sharma, Manish

doi:10.1002/app.23370

Cited by 24 publications

(25 citation statements)

References 48 publications

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“…This clearly brings about a reduction in the swelling ratio of the nanoparticles. Similar types of results were also reported by other workers (38).…”

Section: Effect Of Gelatinsupporting

confidence: 91%

Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: AnIn-VitroKinetic Study

Goswami¹,

Bajpai²,

Bajpai³

2009

Journal of Macromolecular Science, Part A

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In the present investigation gelatin nanoparticles have been synthesized and characterized by various techniques like FTIR, scanning electron microscopy, particle size analysis and surface charge measurements. The particles were allowed to swell in phosphate buffer saline (PBS) and the influence of various factors like chemical composition of nanoparticles, pH and temperature of the swelling bath was investigated on the water intake capacity of the gelatin nanoparticles. The particles were loaded with insulin and the release kinetics of insulin was studied in PBS medium under different conditions. The effects of percent loading of drug, chemical composition of nanoparticles and pH, temperature of the release medium were examined on the release profiles of the drug and the possible mechanisms of drug transport were investigated. The chemical stability of the loaded drug (insulin) was also assessed especially under highly acidic conditions of artificial gastric juice.

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“…This clearly brings about a reduction in the swelling ratio of the nanoparticles. Similar types of results were also reported by other workers (38).…”

Section: Effect Of Gelatinsupporting

confidence: 91%

Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: AnIn-VitroKinetic Study

Goswami¹,

Bajpai²,

Bajpai³

2009

Journal of Macromolecular Science, Part A

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“…13 The intrinsic pathway of thrombosis is recognized to be initiated by the adhesion of plasma proteins, which can activate factor XII within seconds and nally provoke the substantial formation of thrombosis. 13 The intrinsic pathway of thrombosis is recognized to be initiated by the adhesion of plasma proteins, which can activate factor XII within seconds and nally provoke the substantial formation of thrombosis.…”

Section: In Vitro Blood Compatibilitymentioning

confidence: 99%

“…For biomedical applications, such as controlled cell adhesion surfaces and blood contacting materials, biocompatibility is one of the most important and indispensable components. 13 Therefore, further modication is required to improve the antithrombogenicity of NC gels. 12 In addition, the PNIPA-NC gel can adsorb large quantities of BSA.…”

Section: Introductionmentioning

confidence: 99%

Novel hemocompatible nanocomposite hydrogels crosslinked with methacrylated gelatin

Lin

2016

RSC Adv.

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Methacrylated gelatin (MA-gelatin) is a gelatin derivative synthesized by the reaction with methacrylic anhydride; the degree of substitution (DS) of primary amines by methacrylamide groups in the gelatin is closely related to the dosage of methacrylic anhydride. In this work, MA-gelatin has been developed as a macromolecular crosslinker to prepare novel nanocomposite hydrogels (NC gels) based on polyacrylamide (PAAm) and LAPONITE® nanoclay. Compared with unmodified gelatin, MA-gelatin improves the stability of the LAPONITE® suspension in the pre-gel system. FTIR results confirm the success of gelatin modification, in agreement with the 1 H NMR result, and the copolymerization of MA-gelatin and acrylamide monomers in the NC gel network. The increasing DS of MA-gelatin thus reduces the equilibrium swelling ratio (ESR) and pore sizes, and enhances the mechanical properties of the NC gels, due to the macromolecular crosslinking effect. Unlike the small molecular crosslinker N,N 0 -methylenebisacrylamide (BIS), MA-gelatin shows a stronger influence on the swelling behaviours and mechanical properties of NC gels. Moreover, the MA-gelatin crosslinked NC gels exhibit decreased bovine serum albumin (BSA) adsorption, prolonged blood-clotting time and nonhemolytic nature, indicating the improved antithrombogenicity. The results show that MA-gelatin can be a hemocompatible macromolecular crosslinker for the fabrication of biomedical materials.

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“…However, the desired choice of the best method to produce homogeneous composites with specific characteristics remains an unsolved problem. Stimuli-responsive polymers constitute a versatile class of materials finding a wide spectrum of applications in biomedical, pharmaceutical, and industrial fields (5). These polymers can change their volume significantly in response to small alterations of certain environmental parameters.…”

Section: Introductionmentioning

confidence: 99%

Designing Polyaniline (PANI) and Polyvinyl Alcohol (PVA) Based Electrically Conductive Nanocomposites: Preparation, Characterization and Blood Compatible Study

Bajpai¹,

Bajpai²,

Soni³

2009

Journal of Macromolecular Science, Part A

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Novel electrically conducting and biocompatible composite hydrogel materials comprising of poly (aniline) (PANI) nanoparticles dispersed in a poly (vinyl alcohol) (PVA) -g-poly (acrylic acid) (PAA) matrix were prepared by in situ polymerization of aniline. The prepared ionic hydrogels were evaluated for their water uptake capacity in distilled water. While structural insights into the synthesized polymer was sought by Fourier Transform Infrared (FTIR) spectroscopy and X-Ray Diffraction (XRD) techniques, morphology and dimension of PANI particles embedded into the colored optically semi-transparent polymer films were evaluated by Scanning Electron Microscopy (SEM) analysis and Transmittance Electron Microscopy (TEM) while thermal behavior of composite hydrogel was investigated by Differential Scanning Calorimetry (DSC). Electrical conductivity of composite hydrogels containing different PANI percentage was determined by LCR. Considering the potential of electrically conductive nanocomposites materials in biomedical applications the in vitro blood compatibility of nanocomposites was investigated by employing several in vitro tests.

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Preparation and characterization of novel pH‐sensitive binary grafted polymeric blends of gelatin and poly(vinyl alcohol): Water sorption and blood compatibility study

Cited by 24 publications

References 48 publications

Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: AnIn-VitroKinetic Study

Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: AnIn-VitroKinetic Study

Novel hemocompatible nanocomposite hydrogels crosslinked with methacrylated gelatin

Designing Polyaniline (PANI) and Polyvinyl Alcohol (PVA) Based Electrically Conductive Nanocomposites: Preparation, Characterization and Blood Compatible Study

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