Release dynamics of ciprofloxacin from swellable nanocarriers of poly(2-hydroxyethyl methacrylate): an in vitro study

Chouhan, Raje; Bajpai, A. K.

doi:10.1016/j.nano.2009.11.006

Cited by 73 publications

(22 citation statements)

References 21 publications

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“…Several CFX delivery systems have been developed for the treatment of specific infections such as microspheres, multilamellar liposomes, hydrogels, scaffolds, implants membranes, polymer blends or nanoparticles (Aranaz et al, 2009;Budai, 2007;Cho, 2003;Chouhan & Bajpai, 2010;Dias Murbach et al, 2014;DiTizio, 1998;Koort et al, 2008;Ogawa & Plepis, 2002;Venkatasubbu, Ramasamy, Ramakrishnan, & Kumar, 2011;Verma, Bansal, Gosh, & Pandit, 2012;Wang, Dong, Du,& Kennedy, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chitosan based films as supports for dual antimicrobial release

Aranaz

Harris

Navarro‐García

et al. 2016

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 99%

Chitosan based films as supports for dual antimicrobial release

Aranaz

Harris

Navarro‐García

et al. 2016

Carbohydrate Polymers

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“…However, particles above approximately 200 nm must have some kind of deformability in order to avoid deposition in the spleen, were fenestrations typically are 200-500 nm in width [11]. These considerations, combined with the effects of the particle size and compactness on drug release rates [12][13][14], highlight the importance of estimating both the size and the compactness (or deformability) of nanoparticulate drug delivery systems. However, in contrast to the particle size, the particle compactness is seldom reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of ionic strength on the size and compactness of chitosan nanoparticles

2012

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In this work, chitosan nanoparticles were prepared by ionotropic gelation of chitosan with tripolyphosphate (TPP). The effects of the ionic strength of the solvent employed in the particle preparation on the average size and compactness of the particles were investigated. In addition, the effects of the chitosan concentration and the crosslinker to polymer ratio on the particle characteristics were studied. The chitosan-TPP nanoparticles were characterized by dynamic light scattering, zeta potential, and turbidity measurements. The compactness of the nanoparticles was estimated with a method based on the size of the nanoparticles and the turbidity of the nanoparticle suspension. All the investigated preparation parameters, i.e., the ionic strength of the solvent, the chitosan concentration, and the TPP to chitosan ratio, affected the particle characteristics. For instance, smaller and more compact particles were formed in saline solvents, compared to particles formed in pure water. Further, the addition of monovalent salt rendered it possible to prepare particles in the nanometer size range at a higher polymer concentration. Solvent salinity is thus an important parameter to address in the preparation of chitosan nanoparticles crosslinked with TPP.

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“…CFX suffers from moderate oral bioavailability [23], as it chelates with calcium-, magnesium- and aluminium-containing salts upon concomitant administration [24]. In drug delivery systems, CFX has been used with various drug carriers such as polymeric nanoparticles [25-27], cyclodextrin [28], chitosan [29], montmorillonite [30] and calcium apatite [31]. …”

Section: Introductionmentioning

confidence: 99%

Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Latip

Hussein

Stanslas

et al. 2013

Chemistry Central Journal

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BackgroundLayered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol.ResultsPowder x-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the drug anions were successfully intercalated in the interlayer space of LZH. Specific surface area of the obtained compound was increased compared to that of the host due to the different pore textures between the two materials. CFX anions were slowly released over 80 hours in phosphate-buffered saline (PBS) solution due to strong interactions that occurred between the intercalated anions and the host lattices. The intercalation compound demonstrated enhanced antiproliferative effects towards A549 cancer cells compared to the toxicity of CFX alone.ConclusionsStrong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.

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Release dynamics of ciprofloxacin from swellable nanocarriers of poly(2-hydroxyethyl methacrylate): an in vitro study

Cited by 73 publications

References 21 publications

Chitosan based films as supports for dual antimicrobial release

Chitosan based films as supports for dual antimicrobial release

Effects of ionic strength on the size and compactness of chitosan nanoparticles

Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

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