Chitosan based films as supports for dual antimicrobial release

Aranaz, Inmaculada; Harris, Ruth; Navarro‐García, Federico; Heras, Ángeles; Acosta, Niuris

doi:10.1016/j.carbpol.2016.03.064

Cited by 44 publications

(17 citation statements)

References 63 publications

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“…Moreover, after 6 h more than 95% of the silver was released from the scaffold. This release pattern is in good agreement with the silver release from a hydrophilic matrix, in which the hydrophilic polymeric matrix highly swells in aqueous media, allowing a fast release of the antimicrobials from the matrix [23]. Therefore, the minimum inhibitory concentration is largely exceeded in a short time, helping to prevent post-surgical infections.…”

Section: Resultssupporting

confidence: 71%

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

et al. 2016

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The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm.

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Section: Resultssupporting

confidence: 71%

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

et al. 2016

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“…There are commercially available wound dressings made up of chitosan . For the effective wound treatment, wound dressings can be functionalized by incorporation of different bioactive agents . Current wound dressing systems have direct drug loading on polymeric network, which is usually resulted with high burst release.…”

Section: Introductionmentioning

confidence: 99%

Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system

Ozdabak‐Sert

Sen

Kök

2019

J of Applied Polymer Sci

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A multifunctional sandwich type wound dressing was designed in which two types of microspheres, one to alleviate the pain (ibuprofen) and the other to protect the wound from infections (Gentamicin or Ciprofloxacin), were embedded into bilayer chitosan sponge. pH of the wound increases from acidic (pH~5) to basic (pH~8) via infection, so pH-dependent antibiotic release system was designed using gelatin B microspheres to respond to increasing pH. Ibuprofen release from chitosan microspheres, on the other hand, was pH-independent not to intervene with pain management in changing pH conditions. Crosslinking with glutaraldehyde (GA) affected both release profile and size distribution of microspheres and 2.5% GA was chosen to obtain pH-responsive gelatin microspheres with narrow size distribution (80% of microspheres in between 15 and 25 μm). The final system was found to be effective against both Staphylococcus aureus and Escherichia coli and changing pH seemed to affect the antimicrobial agent delivery as desired.

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“…Chitosan, a polysaccharide derived from deacetylation of chitin, exhibits numerous interesting physicochemical and biological properties . Compared with traditional petroleum‐based polymers, chitosan has drawn much attention in a wide variety of fields such as drug delivery, wound dressings, artificial organs, and medical pharmaceuticals because of the biocompatibility, biodegradability, low‐toxicity, and nonimmunogenicity . However, poor water solubility restricts the wide application of chitosan and many approaches have been developed to enhance its water solubility …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Compared with traditional petroleum-based polymers, chitosan has drawn much attention in a wide variety of fields such as drug delivery, wound dressings, artificial organs, and medical pharmaceuticals because of the biocompatibility, biodegradability, low-toxicity, and nonimmunogenicity. [4][5][6][7][8] However, poor water solubility restricts the wide application of chitosan and many approaches have been developed to enhance its water solubility. [9][10][11] To improve the solubility of chitosan, introduction of carboxyl groups at the N-position of the glucosamine units of chitosan is an effective method.…”

Section: Introductionmentioning

confidence: 99%

Zinc ion‐induced formation of hierarchical N‐succinyl chitosan film

Wang

Liu

Zhang

et al. 2017

J of Applied Polymer Sci

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A series of N‐succinyl Chitosan (NSCS) hydrogel derived from different substitution degree of NSCS were fabricated through the zinc ions crosslinking. Subsequently, a light‐weight, transparent, and hierarchical NSCS‐Zn(II) film was obtained by drying the hydrogel. The hierarchical structure of NSCS‐Zn(II) film was confirmed by scanning electron microscopy. The NSCS‐Zn(II) film exhibited excellent mechanical strength because of the preferential formation of the alignment structure. The tensile strength and Young's modulus reaches 119.3 MPa and 2.67 GPa when the NSCS substitution degree was 91.95%. Furthermore, a remarkable and enhanced broad‐spectrum bactericidal properties of the NSCS‐Zn(II) film was revealed through E. coli and S. aureus exposure, respectively. These features indicated that NSCS‐Zn(II) film is a promising material that can be used in biomedical engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44664.

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Chitosan based films as supports for dual antimicrobial release

Cited by 44 publications

References 63 publications

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system

Zinc ion‐induced formation of hierarchical N‐succinyl chitosan film

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