Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Latip, Ahmad Faiz Abdul; Hussein, Mohd Zobir; Stanslas, Johnson; Wong, Charng Choon; Adnan, Rohana

doi:10.1186/1752-153x-7-119

Cited by 45 publications

(11 citation statements)

References 56 publications

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“…The basic character of Z 5 HN could promote the formation of a polluting species, ZnCO 3 , after exposure of the sample to atmospheric conditions . Previous reported works have evidenced the capability of the anionic clays to capture CO 2 because of the high affinity between negative anions and positively charged layers as well as enhancement of the adsorption ability because of the presence of nitrate anions. ,− Values of CO 2 adsorption between 0.49 and 1.4 mmol g –1 have been reported by Sakr . This feature also could have affected the final composition of Z 5 HN synthesized in this study.…”

Section: Resultssupporting

confidence: 61%

Structural Analysis and Conduction Mechanisms in Polycrystalline Zinc Hydroxide Nitrate

Ruiz¹,

Rodríguez‐Castellón

Giraldo³

2018

Inorg. Chem.

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The conduction and dielectric properties in zinc hydroxide nitrate (ZHN) were studied in detail as a function of the temperature and relative humidity by impedance spectroscopy, and the structure was investigated by X-ray diffraction (XRD). Elemental analysis indicated a layered material containing carbonate anions [Zn(OH)(NO)(CO)·1.7HO] due to the high capability of adsorption of ZHN, which makes this material appropriate for applications in real conditions. The water content affected the interlayer distance, conductivity, and dielectric response of the layered material. An electrostatic repulsive interaction after reduction of the water content as a function of the temperature causes an increase of the interlayer distance and a decrease in the conductivity response and dielectric behavior. The highest conductivity, 10 Ω cm, was obtained at a shorter interlayer distance for the sample heat-treated at 25 °C. The ZHN synthesized was also characterized at different temperatures using thermogravimetric analysis and Fourier transform infrared and Raman spectroscopy. Multipeak analysis of the XRD patterns at various relative humidity levels showed the formation of a most hydrated phase and an increase of the interlayer distance related with the adsorption of water molecules. This layered material presented a conductivity of 10 Ω cm at high relative humidity (92%). The dipole-dipole interaction appeared to be the dominant mechanism for the dielectric behavior at the lowest temperatures and highest humidity due to the high water content in the ZHN structure. Taking into account its crystallization water and high adsorption of water molecules in the interlayer region, a conduction pathway in the ZHN structure was proposed, which provides the route for proton transport by hydrogen-bonding networks on the basis of a Grotthuss-type mechanism in facilitating the long-range proton hopping at 25 °C. The results for high relative humidity imply that a vehicular conduction mechanism also may contribute to the electrical response.

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Section: Resultssupporting

confidence: 61%

Structural Analysis and Conduction Mechanisms in Polycrystalline Zinc Hydroxide Nitrate

Ruiz¹,

Rodríguez‐Castellón

Giraldo³

2018

Inorg. Chem.

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“…At 1705 and 1620 cm −1 the peaks are due to the stretching vibrations of the carbonyl group of carboxylic acid and ketone, respectively. The 1444 cm −1 peak is attributed to C–H bending or C–O, the 1271 cm −1 is due to C–C–C of ketone, and the 1045 cm −1 is due to C–F [ 27 , 29 – 31 ].…”

Section: Resultsmentioning

confidence: 99%

Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

Murbach

Ogawa

Borges

et al. 2014

International Journal of Biomaterials

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Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

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“…Layered zinc hydroxides are promising materials for application in anion exchange and can be synthesized by direct precipitation methods, through adding sodium hydroxide to aqueous solutions of zinc salts [11][12][13]. Therefore, layered zinc hydroxides are expected to function as ion exchange agents that can effectively remove P from wastewater [14][15][16].…”

Section: −mentioning

confidence: 99%

Effect of pH and aging temperature on the phosphorus removal properties of layered hydroxide synthesized from zinc acetate

Agario

Shiomi

2018

Journal of Asian Ceramic Societies

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Zinc hydroxide acetate (ZHA) is a promising material for anion exchange applications because it has a layered structure with intercalating CH 3 COO − and H 2 O. ZHA can be synthesized through a direct precipitation method by adding sodium hydroxide solution to a Zn(OCOCH 3) 2 solution. In this study, ZHAs were synthesized under various conditions and tested as phosphorous removal agents. The ZHA precipitates were obtained at pH 6, 7, and 9. They were then aged at 25°C, 60°C, 90°C, and 120°C under hydrothermal conditions. At pH 6, nearly pure single-phase ZHAs were obtained regardless of the aging temperature. On the other hand, most of the ZHAs that were prepared at higher pH and aged at higher temperature were transformed to ZnO. For the phosphorous removal experiments, the single-phase ZHA precipitates removed approximately 99% of the phosphate ions in a 100 mg L −1 phosphorous solution, and the phosphorus removal efficiency decreased with increasing amounts of ZnO. Therefore, ZHAs that were prepared at lower pH and aged at lower temperatures contained little to no ZnO, thereby showing high phosphorous removal capabilities.

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Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Cited by 45 publications

References 56 publications

Structural Analysis and Conduction Mechanisms in Polycrystalline Zinc Hydroxide Nitrate

Structural Analysis and Conduction Mechanisms in Polycrystalline Zinc Hydroxide Nitrate

Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

Effect of pH and aging temperature on the phosphorus removal properties of layered hydroxide synthesized from zinc acetate

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