Relationships of Systemic Oxidative Stress to Body Fat Distribution, Adipokines and Inflammatory Markers in Healthy Middle-aged Women

Wu, Bin; Fukuo, Keisuke; Suzuki, Kazuhisa; Yoshino, Gen; Kazumi, Tsutomu

doi:10.1507/endocrj.k08e-332

Cited by 45 publications

(38 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in both study groups the blood levels were measured during fasting and all subjects reported stable weight for at least two months prior to inclusion. Few studies have shown the same trend with leptin levels in lean people, but a positive association between fat mass accumulation, oxidative stress indices and leptin levels has been observed, 7 suggesting that fat mass-induced oxidative stress may cause a dysregulation of adipokines, also in lean subjects. A positive relationship between BMI, waist circumference and CRP has been documented.…”

Section: Discussionmentioning

confidence: 95%

“…5 It is well known that inflammatory markers are associated with fat mass in overweight and obese subjects, 6 but this relation between fat mass and inflammatory markers in lean subjects is not well documented. 7 Several methods are used to measure the amount of fat in adults. One of the most accurate methods is Dual-energy X-ray absorptiometry (DXA), 7 but measuring fat this way is costly and not readily available in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…7 Several methods are used to measure the amount of fat in adults. One of the most accurate methods is Dual-energy X-ray absorptiometry (DXA), 7 but measuring fat this way is costly and not readily available in clinical practice. Bioelectrical impedance analysis (BIA) is more available and widely used outside hospitals, 8 and an objective, quick and non-invasive method for assessment of fat and fat free mass.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measurements of body fat is associated with markers of inflammation, insulin resistance and lipid levels in both overweight and in lean, healthy subjects

et al. 2012

View full text Add to dashboard Cite

s u m m a r yBackground & aims: Low-grade inflammation is associated with fat mass in overweight. Whether this association exists in lean persons is unknown. Aims were to investigate associations between anthropometric measures of fat distribution and fat mass (% and kg) assessed by bioelectrical impedance analysis (BIA). Furthermore we wanted to investigate the relationship between fat mass and markers of insulin resistance, inflammation, and lipids in healthy subjects in different BMI categories. Methods: We compared 47 healthy overweight adults (BMI 26e40 kg/m 2 ) and 40 lean (BMI 17e25 kg/ m 2 ) matched for age and sex. Waist and hip circumferences, waist-to-hip ratio, waist-to-height ratio and triceps skinfold were used to evaluate fat distribution. BIA was used to estimate fat mass (% and kg). Markers of insulin resistance, lipids, inflammation and adipokines were measured. Results: Hip circumference was associated (P < 0.01) with BIA-assessed fat mass (%) in both groups (lean: regression coefficient B ¼ 0.4; overweight: B ¼ 0.5). An increase in hip circumference in all tertiles was associated with higher plasma levels of leptin, CRP and C-peptide in both groups. Conclusions: Fat mass may play a role in low-grade inflammation also in subjects within the normal range of BMI. Hip circumference may be a surrogate measure for fat mass in subjects in different BMI categories, and may be useful for identification of people with risk of developing overweight-related chronic diseases.Ó

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Measurements of body fat is associated with markers of inflammation, insulin resistance and lipid levels in both overweight and in lean, healthy subjects

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Daughters were students of the University and the characteristics of the daughters 10) and their mothers 11) are described in detail elsewhere. Body composition was determined using whole-body DXA (QDR-2000, software version 7.20D; Hologic, Bedford, MA, USA) as previously reported 10) . The software provides estimates of lean tissue mass, fat mass, and bone mineral mass for the total body and for standard body regions.…”

Section: Methodsmentioning

confidence: 99%

Associations of 18-Year-Old Daughters' and Mothers' Serum Leptin, Body Mass Index and DXA-Derived Fat Mass

Tanaka

Honda

et al. 2010

JAT

Self Cite

View full text Add to dashboard Cite

Aim and Methods:We assessed the relationship of the body mass index (BMI) of 187 college female students aged 18 years with the reported BMI of their middle-aged biological parents measured on 2 occasions: when the parents were 18 − 20 years old and at the time of the study. The relationships of fat mass measured using whole body dual energy X-ray absorptiometry (DXA) and serum leptin levels were also determined between 148 daughters and middle-aged parents (148 mothers and 59 fathers).

show abstract

“…Estudos mostram que o ganho de peso aumenta a formação de substâncias pró-oxidantes e também mostram que indivíduos obesos tem perfil oxidativo acentuado quando comparados a indivíduos normais. A obesidade tem relação com outros estados mórbidos (hipertensão arterial, resistência à insulina, DM2, dislipidemia e complicações vasculares) que possuem relação com o desencadeamento do desbalanço oxidativo [39][40][41].…”

Section: /7unclassified

Aspectos oxidativos da síndrome metabólica e aterosclerose

Barbalho¹,

Quesada²,

Goulart³

et al. 2015

Sci Med

View full text Add to dashboard Cite

Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR Aspectos oxidativos da síndrome metabólica e aterosclerose ABStRActAims: To review the literature on the current aspects of oxidative stress and its role in metabolic syndrome and in atherosclerosis. Methods:The study was performed in April and May 2015 and the following databases were used: PubMed, SciELO, and LILACS, including articles published from 2011 onwards. The following keywords were used: oxidative stress and atherosclerosis or oxidative stress and metabolic syndrome. Meta-analyses and clinical trials with a large sample size were preferred. Results: A total of 3,934 articles were available in the databases (PubMed 3,292; SciELO 588; and LILACS 54). Fifty-three articles were included in the review after eliminating double references and using the inclusion criteria. Conclusions: Biochemical and anthropometric findings characteristic of the metabolic syndrome are related to inflammatory processes and to oxidative stress which, in turn, are closely related to atherosclerosis. A better understanding of how the conditions that underlie metabolic syndrome predispose to oxidative stress may significantly contribute to the treatment of patients with cardiovascular disease in the future.KEY WORDS: metabolic syndrome x; oxidative stress; atherosclerosis.

show abstract

Relationships of Systemic Oxidative Stress to Body Fat Distribution, Adipokines and Inflammatory Markers in Healthy Middle-aged Women

Cited by 45 publications

References 49 publications

Measurements of body fat is associated with markers of inflammation, insulin resistance and lipid levels in both overweight and in lean, healthy subjects

Measurements of body fat is associated with markers of inflammation, insulin resistance and lipid levels in both overweight and in lean, healthy subjects

Associations of 18-Year-Old Daughters' and Mothers' Serum Leptin, Body Mass Index and DXA-Derived Fat Mass

Aspectos oxidativos da síndrome metabólica e aterosclerose

Contact Info

Product

Resources

About