Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA®) defined sperm DNA and chromatin integrity

Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

“…phthalate exposure, air pollution, high temperature), lifestyle (e.g. obesity; smoking), infection, fever, radiotherapy, chemotherapy and ageing have been related to SDF (Evenson et al, 2000(Evenson et al, , 2020Jurewicz & Hanke, 2011;Jurewicz et al, 2009;O'Flaherty et al, 2008;Rubes et al, 2007;Schmid et al, 2007;Wyrobek et al, 2006). However, extrinsic factors' potential adverse effect is not universal, suggesting that genetic predisposition gives some individuals the ability to metabolise toxic products with increased efficiency (Chengyong et al, 2012;Evenson & Wixon, 2005;Rubes et al, 2007).…”

“…Sperm DNA fragmentation increases with paternal age, particularly among men aged 40 years and older (Evenson et al, 2020;Rosiak-Gill et al, 2019;Simon et al, 2014 (Evenson et al, 2020). The authors used a logistic regression model to estimate the probability of having elevated SDF by age factor alone.…”

Analysis of age‐associated alternation of SCSA sperm DNA fragmentation index and semen characteristics of 1790 subfertile males in China

“…12,13 In the past decades, age-related declines in semen quality have been reported in men aged >35 years, and these changes become more significant with age >40 years. 14,15 Moreover, reproductive outcomes can get worse with a male age of >40 or even >35 years, commonly classified as "advanced" age. 14,16 Deterioration in semen quality is evident not only in terms of ejaculate volume, sperm count, motility, vitality, and sperm morphology, 17 but also in sperm chromatin quality.…”

“…In the past decades, age‐related declines in semen quality have been reported in men aged >35 years, and these changes become more significant with age >40 years 14,15 . Moreover, reproductive outcomes can get worse with a male age of >40 or even >35 years, commonly classified as “advanced” age 14,16 .…”

Male fertility: review of the publications of July - September 2020

“…В данном исследовании был подтверждён факт повышения уровня фрагментации ДНК сперматозоидов с возрастом мужчины [9]. Помимо общего тренда к повышению показателя с возрастом, наиболее резко фрагментация начинает расти после возраста 41,6 лет (в большинстве работ «отсечкой» старшего отцовского возраста принято считать возраст 40 лет).…”