Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

Abstract

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Increasing awareness about male infertility: an overview of the Sperm DNA Fragmentation Study Group (SFRAG) Guidelines

“…This commentary highlights the recently published evidence-based guideline from the Sperm DNA Fragmentation Study Group (SFRAG), which provides a comprehensive summary about the role of SDF in infertility and offers best practice advice on testing and care of couples with SDF [9]. The primary goals of the SFRAG guideline are to provide cliniciansurologists, andrologists, gynecologists, and reproductive endocrinologists-with clear advice on best practices in SDF.…”

“…A pictorial summary of the recommendations for SDF testing and possible management in couples with high SDF Reprinted with permission. Esteves SC, et al [9] IUI: intrauterine insemination; IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; RPL: recurrent pregnancy loss.…”

Afterword: An update on clinical utility and diagnostic value of various andrological techniques

“…In another article, Esteves and colleagues reviewed currently available data on wide‐ranging clinical scenarios that warrant SDF testing and expanded on the existing recommendations based on up‐to‐date best evidence and expert opinion (Esteves et al., 2020). The authors reiterated the need for further comprehensive clinical practice guidelines with higher quality of evidence to improve upon the existing guidelines available in practice.…”

Time has come to provide infertile men with an optimal fertility pathway

“…As ICSI experience increased, it became evident that the paternal factor plays a role in its success rates (4,6). Moreover, reports suggesting that interventions aimed at ameliorating sperm quality before ICSI could increase its success rates are increasing steadily (7).…”

“…Sperm functional tests, mainly those that assess sperm chromatin integrity, have become essential tools to investigate the role of a possible paternal factor and guide clinical management. In these lines, readers are invited to examine recently published articles in this and other Journals, highlighting the clinical utility of including sperm functional tests to the male infertility work--up (2,4,6,7,(10)(11)(12).…”