Relationships between plasma levels of nitrogenous metabolites and some psycho-neuro-endocrine parameters

Abstract

Background. It was recently shown by our group that bilirubin has a neurotropic activity. It is also shown that endogenous uric acid exerts a noticeable modulating effect on neuro-endocrine adaptation factors. In this study, we supplemented the constellation both of subjects of influence with other nitrogenous metabolites - urea and creatinine, and the objects of influence - with plasma levels of the main adaptation hormones and the severity of trait and reactive anxiety. Materials and Methods. The object of observation were almost healthy volunteers: 30 females (30÷76 y) and 31 males (24÷69 y). In basal conditions determined plasma levels of nitrogenous metabolites as well as cortisol, aldosterone, testosterone, triiodothyronine and calcitonin, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By constructing regression models, it was found that direct bilirubin determines the levels of psycho-neuro-endocrine parameters by 66,0%, free bilirubin by 56,7%, uric acid by 40,8%, creatinine by 37,6%, and urea - by 31,1%. Taken together, nitrogenous plasma metabolites determine the severity of trait, but not reactive anxiety, plasma levels of testosterone, cortisol and triiodothyronine, but not calcitonin and aldosterone, as well as a number of HRV and EEG parameters by 70,6%. Conclusion. Nitrogenous plasma metabolites, even in the absence of uremia, are able to influence the state of the psyche, autonomic and central nervous and endocrine systems, apparently through aryl hydrocarbon and adenosine receptors of neurons and endocrinocytes and/or directly.

Psycho-neuro-endocrine accompaniments of individual variants of nitrogenous metabolites exchange

“…In addition to routine parameters, HRV and EEG Entropy were calculated [8,22,26]. See the previous article for details [6].…”

“…Earlier we showed, by constructing regression models, that plasma nitrogenous metabolites, even in the absence of uremia, are able to influence the state of the trait anxiety, autonomic and central nervous and endocrine systems at practically healthy volunteers with maladaptation [5,6,14,21]. In this study of the same cohort, other methodological approaches were used, namely cluster and discriminant analyses.…”

Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters

“…The object of observation were employees of the clinical sanatorium "Moldova" and PrJSC "Truskavets' Spa": 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). The volunteers were considered practically healthy (without a clinical diagnosis), but the initial testing revealed deviations from the norm in a number of parameters of the neuro-endocrine-immune complex as a manifestation of maladaptation [4,5].…”

“…In addition to routine parameters, Shannon's CE [18] Entropy of HRV and EEG were calculated [9,15]. See the previous articles for details [3][4][5].…”

“…The purpose of this study, carried out as part of the "Neuro-endocrine activity of nitrogenous metabolites" project [3][4][5]14], is to analyze the relationships between the plasma urea level and some psycho-neuro-endocrine parameters in the same cohort.…”