Psycho-neuro-endocrine accompaniments of individual variants of nitrogenous metabolites exchange

Background. Earlier we found a strong urato-neural relationships in both men and women. Moreover, in women, the factor structure of the neural root is almost completely different from that in men. In addition, significant differences were found between the profiles of urato-neural correlations of women of reproductive age and postmenopausal women. The purpose of this study is to analyze the relationships between the plasma urea level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of urea and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma urea positively determines (R2=0,499) the level of circulating catecholamines and power spectrum density (PSD) of δ-, θ- and β-rhythms in different loci. In postmenopausal women, urea downregulates the amplitude and PSD of δ-rhythm in different loci, instead, it upregulates the PSD of α-rhythm in T5 locus, entropy of EEG in 2 loci and vagal tone. The degree of determination of neural parameters is 71,6%. In women of reproductive age the degree of determination of neural parameters is similar (69,9%), but the factor structure of the model is completely different. Urea upregulates the PSD of β-rhythm in F7 locus while downregulates the levels of reactive anxiety, vagal tone, entropy of EEG in 3 loci and P4-θ PSD as well as causes left lateralization of θ- and α-rhythms. Conclusion. Plasma urea has a modulating effect on EEG&HRV parameters, as well as reactive anxiety, but this effect is significantly different in men and women of different ages.

Section: Methodsmentioning

confidence: 99%

“…In addition to routine parameters, Shannon's CE [18] Entropy of HRV and EEG were calculated [9,15]. See the previous articles for details [3][4][5].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters

Bombushkar¹,

Anchev²,

Żukow³

et al. 2022

“…The object of observation were employees of the clinical sanatorium "Moldova" and PrJSC "Truskavets' Spa": 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). The volunteers were considered practically healthy (without a clinical diagnosis), but the initial testing revealed deviations from the norm in a number of parameters of the neuro-endocrineimmune complex as a manifestation of maladaptation [4,6].…”

Section: Methodsmentioning

confidence: 99%

“…Earlier we found that plasma uric acid and urea causes modulating effects on neuro-endocrine parameters, as well as reactive anxiety, but these effects are significantly different in men and women of different ages [4][5][6][7]14].…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism in relationships between of plasma creatinine and some neuro-endocrine parameters

Bombushkar

Anchev²,

Żukow

et al. 2022

Background. Earlier we found that plasma uric acid and urea causes modulating effects on neuro-endocrine parameters, as well as reactive anxiety, but these effects are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma creatinine level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of creatinine and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma creatinine downregulates the level of Cortisol (r=-0,41) while upregulates the levels of Testosterone (r=0,36) and Calcitonin (r=0,30). The degree of determination of endocrine parameters is 31,9%. In postmenopausal women, creatinine also upregulates Testosterone (r=0,43) while downregulates the amplitude and PSD of β-rhythm in different loci as well as causes right lateralization of β-rhythm. The degree of determination of neuro-endocrine parameters is 61,2%. In women of reproductive age creatinine upregulates the PSD of ULF band HRV and α-rhythm in 5 loci as well as the Entropy of EEG in F3 locus while downregulates the Entropy in T6 locus, F3-δ and T6-θ PSD as well as Cortisol level. The degree of determination of neuro-endocrine parameters is 94,0%. Conclusion. Plasma creatinine has a modulating effect on neuro-endocrine parameters, but this effect is significantly different in men and women of different ages.

Features of the state of the neuroendocrine-immune complex and electrolyte-nitrogenous exchange under different variations of uric acid metabolism in female rats

Bombushkar

2020

Background. This article concludes the experimental part of the project "Physiological activity of uric acid". Our group previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters as well as plasma and urine electrolytes and nitrogenous parameters, which to one degree or another correlate with uricemia and uricosuria. Because the autonomic, endocrine and immune parameters interact with each other within the neuro-endocrine-immune complex, the purpose of this study is to find out exactly which parameters of the neuro-endocrine-immune complex reflect the specificity of quantitative and qualitative clusters of uric acid metabolism. Materials and Methods. Experiment was performed on 60 healthy female Wistar rats 220-300 g. The plasma and urine levels of the uric acid, urea, creatinine, calcium, phosphates, chloride, magnesium, sodium and potassium (also in erythrocytes) as well as glucose (in plasma only) were determined. The parameters of the autonomic, endocrine and immune systems were registered. Results. 30 parameters of the neuroendocrine-immune complex and metabolism were identified, which collectively reflect the specificity of quantitative and qualitative clusters of uric acid metabolism. In addition to, by definition, uricemia and uricosuria, they represent markers of vagal tone, sympatho-vagal balance, androgenic, mineralocorticoid and glucocorticoid functions of the adrenal cortex as well as parathyroid activity; exchange of electrolytes (excretion with urine of sodium, calcium and phosphates, plasma levels of sodium, magnesium, chloride, phosphates and potassium and the latter in erythrocytes) and nitrogenous metabolites (creatininuria and plasma urea); as well as immunity parameters (the percentage of lymphoblasts, plasma cells and macrophages in the thymocytogram, the mass of the spleen, the entropy of the splenocytogram and the percentage of macrophages and microphages in it, the percentage of Th-, B- and 0-lymphocytes in the blood immunocytogram as well as blood level of leukocytes in general). Conclusion. The quantitative and qualitative clusters of uric acid metabolism are accompanied by specific constellations of parameters of the neuro-endocrine-immune complex and the electrolytes and nitrogenous compounds.