Relationships between low serum vitamin D levels and HBV “a” determinant mutations in chronic hepatitis B patients

Zhu, Huijuan; Liu, Xingxiang; Ding, Yan; Zhou, Hui; Wang, Yiying; Zhou, Zhiwei; Li, Xinxin; Zhang, Zengli; Dong, Chen

doi:10.3855/jidc.7459

Cited by 5 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Additionally, our another studies observed that vitamin D deficiency was significantly associated with the mutation frequency of M133 in HBV infected patients, indicating that the obesity might lead to an increased risk of HBV vaccine-escape mutations. 33 …”

Section: Discussionmentioning

confidence: 99%

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Liu¹,

Guo

Dong

2017

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

Objective: Hepatitis B vaccine is regarded as the most effective method for the prevention of hepatitis B virus (HBV) infection. However, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. The present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis B vaccines. Data sources: Available peer-reviewed literatures, practice guidelines, and statistics published on hepatitis B vaccine in obesity between 1973 and 2015. Conclusions: Obesity was significantly associated with non-response to hepatitis B vaccine immunization. The risk of nonresponsiveness of hepatitis B vaccine among obese people increased with BMI. Moreover, the obesity might lead to an increased risk of HBV vaccine-escape mutations. The mechanism responsible for decreased immunization responses in obesity included leptininduced systemic and B cell intrinsic inflammation, impaired T cell responses and lymphocyte division and proliferation. Therefore, more studies should be performed to analyze the influences of obesity on the immunogenicity of hepatitis B vaccines to improve the immunoprotecive effect of hepatitis B vaccines in future.

show abstract

Section: Discussionmentioning

confidence: 99%

Influences of obesity on the immunogenicity of Hepatitis B vaccine

Liu¹,

Guo

Dong

2017

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Genotypes C and B are the major causes of chronic hepatitis B and subsequent LC and HCC in East Asia[ 90 - 92 ]. Recent studies indicate that patients infected with genotype B had a higher prevalence of vitamin D insufficiency than those infected by the C genotype[ 23 , 93 ].…”

Section: Vitamin D Deficiency In Chronic Hepatitis B and Cmentioning

confidence: 99%

Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review

Hoàn

Tong

Song

et al. 2018

WJG

View full text Add to dashboard Cite

The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses (HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response (SVR) to interferon (IFN) plus ribavirin (RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBV- and HCV-related chronic liver diseases. Furthermore, current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients.

show abstract

“…For example, a study by Huijuan Zhu et al. showed that genotype B virus is more affected by vitamin D [ 118 ]. This statement has been confirmed by other studies [ 119 ].…”

Section: Role Of Vitamin D In Immune Systemmentioning

confidence: 99%