Vitamin D role in hepatitis B: focus on immune system and genetics mechanism

Asghari, Arghavan; Jafari, Fatemeh; Jameshorani, Maryam; Chiti, Hossein; Naseri, Mohsen; Ghafourirankouhi, Anahita; Kooshkaki, Omid; Abdshah, Alireza; Parsamanesh, Negin

doi:10.1016/j.heliyon.2022.e11569

Cited by 5 publications

(6 citation statements)

References 173 publications

(178 reference statements)

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“…NAFLD has become a global public health issue since it is linked to metabolic risk factors such as obesity, diabetes mellitus, dyslipidemia, and metabolic syndrome, along with genetic, socioeconomic, and lifestyle components. 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 Increased endothelial dysfunction, 91 , 92 ischemic heart disease, 93 cardiovascular events, 93 , 94 , 95 peripheral vascular disease, cardiovascular morbidity, and cardiovascular mortality are all medical issues, which may be caused by NAFLD. 87 , 96 Other research has shown an independent link between NAFLD and cardiovascular disease, regardless of other metabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Khoshbaten,

Maleki,

Hadad

et al. 2023

Health Science Reports

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IntroductionThe relationship between cardiovascular disorders and nonalcoholic fatty liver disease (NAFLD) has been extensively studied. To better pool this data and make a more definite conclusion, we performed a meta‐analysis to evaluate the association between NAFLD and the thickness of media and intima of carotid artery (CIMT) and cardiovascular disorders.MethodsWe searched PubMed, Ovid, Scopus, ProQuest, Web of Science, and the Cochrane Library, and analyzed the pooled data using R studio and the “metafor” package.ResultsThe final analysis included a total of 59 studies with 16,179 cases and 26,120 control individuals. NAFLD was shown to be associated with an increase of 0.1231 mm (20.6%) in carotid artery intima‐media thickness (CIMT) (p = 0.002, 95% confidence interval [CI]: 0.0462–0.2000) in individuals with NAFLD. The prevalence of atherosclerotic plaques in the carotid arteries and the occurrence of NAFLD are significantly correlated, according to a meta‐analysis based on 17 distinct studies (p = 0.001, 1.28–1.43, 95% CI, odds ratio = 1.356).ConclusionPatients with increased CIMT are considerably more likely to have NAFLD. Large prospective investigations are required to corroborate these findings and their prognostic significance, along with the effectiveness of the available interventions.

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Section: Discussionmentioning

confidence: 99%

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Khoshbaten,

Maleki,

Hadad

et al. 2023

Health Science Reports

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“…VitD deficiency is associated with an increased occurrence of several viral diseases, such as hepatitis, influenza viruses, respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), COVID-19, and AIDS ( 32 , 34 ). Several studies have indicated that double-stranded DNA (dsDNA) viruses, such as HBV and single-stranded RNA (ssRNA) virus (such as hepatitis C virus [HCV]), can inhibit the VitD signaling pathway to attenuate the immune response ( 34 – 37 ). Although VDR mRNA and protein levels are significantly repressed by HBV, Epstein-Barr virus (EBV), cytomegalovirus (CMV).…”

Section: Discussionmentioning

confidence: 99%

Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication

et al. 2023

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“…25,26 Vitamin D may alter the immunological response to HBV infection, affecting the equilibrium between viral eradication and immune-mediated liver damage. 17,26 Previous studies have shown that vitamin D increases the…”

Section: Discussionmentioning

confidence: 99%

“…16 Some studies even report a lack of connection between vitamin D levels and HBV viral infection. 17 In summary, the current evidence is inconclusive, necessitating further research to elucidate the relationship between anti-HBs and Vitamin D.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Vitamin D Status and HBsAg Antibody Levels in Indonesian Adolescents Immunised Against Hepatitis B

Girsang,

Rusmil,

Fadlyana

et al. 2023

IJGM

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Hepatitis B virus (HBV) infection is a global health problem. Anti-hepatitis B surface antigen (HBsAg) levels increase along with vitamin D levels in adults. However, few studies have examined this relationship in adolescents. Few studies have examined the relationship between vitamin D and HBsAg antibody levels, especially in Indonesia. Methods: This cross-sectional study examined vitamin D and anti-HBsAg levels before and after hepatitis B immunisation. All subjects blood was taken to check for vitamin D level. This study was part of the Safety and Preliminary of Immunogenicity Following Recombinant Hepatitis B (Bio Farma) Vaccine in Adults and Children Phase I trial. Results: This study found that 25-hydroxyvitamin D [25(OH)D] status was primarily deficient based on endocrine criteria. The children's hepatitis B antibody response was mostly <10 mIU/mL before and ≥10 mIU/mL after vaccination. There was a relationship between sex and 25(OH)D status, with median 25(OH)D levels higher in females (18.2 ng/mL) than in males (9.8 ng/mL). However, the relationship between vitamin 25(OH)D status and anti-HBsAg levels pre-and post-vaccination was not significant. Discussion: However, some research found that vitamin D supplementation after immunisation did not impact vaccine response, several studies have reported that vitamin D can decrease HBV replication through various mechanisms, including reducing viral transcription and interfering with viral protein synthesis. Conclusion:There was no relationship between 25(OH)D status and anti-HBsAg levels. Further research is needed to elucidate the underlying mechanisms and establish optimal treatment strategies.

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Vitamin D role in hepatitis B: focus on immune system and genetics mechanism

Cited by 5 publications

References 173 publications

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication

Correlation Between Vitamin D Status and HBsAg Antibody Levels in Indonesian Adolescents Immunised Against Hepatitis B

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