Relationships between follicular fluid steroid hormone concentrations, oocyte maturity, in vitro fertilization and embryonic development in the rhesus monkey

Morgan, Patricia M.; Boatman, Dorothy E.; Bavister, Barry D.

doi:10.1002/mrd.1080270209

Cited by 38 publications

(19 citation statements)

References 36 publications

(55 reference statements)

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“…Due to the lack of sufficient hormonal support of P 4 , oocyte maturation is arrested and the subsequent processes, including fertilization, blastocyst formation and embryo development, are negatively affected. This hypothesis is in accordance with previous experiments on rhesus monkeys, which reported that a higher ratio of P 4 to E 2 in the FF was beneficial for the development of the embryos (72). In addition, this is consistent with the findings of Gustafson et al (73), suggesting that a higher E 2 /P 4 ratio in the FF was associated with a lower IVF success rate.…”

Section: Discussionsupporting

confidence: 93%

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

et al. 2017

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Abstract. Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed the levels of AOPPs, estradiol (E 2 ) and progesterone (P 4 ) in the follicular fluid (FF) of 89 women with or without EM undergoing in vitro fertilization (IVF). The AOPP concentration in the FF of the EM group was significantly higher when compared with that of the control group (51.5±22.4 vs. 41.8±18.3 µmol/l; P<0.05). However, the FF P 4 levels and blastocyst rate were significantly lower in the EM group compared with the control group (P 4 :1,249.6±465.4 vs. 1,752.7±565.4 ng/ml, P<0.05; blastocyst rate: 0.511±0.322 vs. 0.662±0.278; P<0.05). The AOPP concentration and P 4 level in the FF presented a significant negative correlation in the EM and control groups, as well as in the total cohort of patients (EM group: r=-0.406, P=0.006; control group: r=-0.315, P=0.035; total: r=-0.421, P<0.001). In addition, there was a significant negative correlation between the FF AOPP concentrations and blastocyst rate in the EM group and in the total cohort (EM group: r=-0.376, P=0.012; total: r=-0.367, P<0.001). In conclusion, these results suggested that AOPPs may be a potentially effective marker for predicting the oocyte quality and outcomes of IVF in infertile women with EM.

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Section: Discussionsupporting

confidence: 93%

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

et al. 2017

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“…Finally, the culture environment needed to support the meiotic maturation of all oocytes may be inadequate. Previous studies [31,32] on primate oocyte maturation have been conducted without regard to menstrual cycle phase, presumably because of resource scarcity.…”

Section: Discussionmentioning

confidence: 99%

Rhesus Monkey Oocyte Maturation and Fertilization in Vitro: Roles of the Menstrual Cycle Phase and of Exogenous Gonadotropins1

Alak

Wolf

1994

Biology of Reproduction

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Our objectives were to improve the efficiency of rhesus monkey oocyte maturation and fertilization in vitro and to determine the influence of menstrual cycle phase and exogenous gonadotropins on these processes. Immature oocytes were recovered from antral follicles of ovaries excised from unstimulated animals (n = 14). The highest yield and quality was associated with oocytes obtained from early follicular phase ovaries, and more of these oocytes underwent germinal vesicle breakdown (GVBD; 55%) and matured to metaphase II (MII; 40%) than did oocytes from late follicular (GVBD, 28%; MII, 9%) or luteal (GVBD, 13%; MII, 10%) phase ovaries. Exogenous human (h) FSH and hLH improved GVBD and MII levels for oocytes recovered from late follicular phase ovaries and increased GVBD, but not MII, for oocytes from luteal phase ovaries. MII levels for oocytes from early follicular phase ovaries were adversely affected. Early follicular phase oocytes underwent GVBD faster and attained MII sooner than did those from either late follicular or luteal phase ovaries. Whereas exogenous gonadotropins did not significantly affect oocyte fertilization, follicular phase oocytes tended to be fertilized at a higher rate (p = 0.07). These results demonstrate that higher maturation levels are obtained with oocytes from early follicular phase ovaries and that gonadotropins influence oocyte performance in a cycle phase-dependent manner.

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“…It has been reported that the high concentration of progesterone in follicular fluid induces meiotic maturation of rhesus monkey oocytes [22]. During in vitro maturation of COCs, progesterone was produced by cumulus cells, and the level of progesterone in the medium was increased by stimulation with FSH and/or LH in humans [23,24] and pigs [14,20].…”

Section: Discussionmentioning

confidence: 99%

Progesterone is Essential for Maintenance of Tace/Adam17 mRNA Expression, But not EGF-like Factor, in Cumulus Cells, Which Enhances the EGF Receptor Signaling Pathway During In Vitro Maturation of Porcine COCs

Yamashita

Kawashima

Gunji

et al. 2010

Journal of Reproduction and Development

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Abstract. During in vitro maturation of porcine cumulus-oocyte complexes (COCs), progesterone was secreted from cumulus cells and acted on the cumulus cells themselves, which required for cumulus expansion and oocyte maturation. EGF-like factor (amphiregulin, AREG; epiregulin, EREG) and its protease, TACE/ADAM17, are also expressed in cumulus cells, and thereby, soluble EGF domain was acted on the EGF receptor expressed on cumulus cells. In this study, we examined the relationship between progesterone function and EGF-like factor stimuli in cumulus cells of porcine COCs. When COCs were cultured with FSH and LH, Areg, Ereg and Tace/Adam17 were expressed in cumulus cells. Treatment with a progesterone receptor (PGR) antagonist, RU486, did not affect the Areg and Ereg mRNA expression levels at any culture time points. However, the Tace/Adam17 mRNA level, protein level and its activity were significantly suppressed by RU486 at the 30 or 40 h time point. At 20 h of culture, phosphorylation of ERK1/2 and the expressions of target genes (Has2, Tnfaip6 and Ptgs2) were not suppressed by RU486; however, at 40 h, ERK1/2 phosphorylation and the target gene expression levels were significantly downregulated by RU486 in cumulus cells. Furthermore, the negative effects of RU486 at 40 h were overcome by the addition of EGF. These results indicated that the level of TACE/ADAM17 in cumulus cells was regulated by the progesterone-PGR pathway during in vitro maturation of porcine COCs. Therefore, we concluded that the progesterone-induced TACE/ADAM17 leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes during in vitro maturation of porcine COCs. Key words: Cumulus expansion, EGF-like factor, Oocyte maturation (J. Reprod. Dev. 56: [315][316][317][318][319][320][321][322][323] 2010) n mammals, the LH surge acted on granulosa cells, and induced the ovulation process. During this period, the estrogen concentration was decreased, whereas the progesterone concentration was risen in follicular fluid concomitantly with the downregulation of Cyp19a1 mRNA and upregulation of Cyp11a1 and Hsd3b1 mRNA in granulosa and/or cumulus cells [1,2]. Numerous functions of progesterone were mediated by the intracellular receptor, progesterone receptor (PGR) [3][4][5]. PGR was induced in the granulosa cells of the rat preovulatory follicle by LH [6,7]. Pgr knockout mice (PRKO) fail to ovulate [8,9], indicating that the progesterone-dependent pathway played a critical role in functional change of follicular cells during the ovulatory process.The EGF-like factor (amphiregulin, AREG; Epiregulin, EREG;β-cellulin, BTC) is expressed in granulosa cells and cumulus cells in the rodent and pig in response to ovulational stimuli [10,11]. The cleaved enzyme of EGF-like factor, TACE/ADAM17, is also expressed in porcine granulosa cells after hCG administration in vivo [12]. Since double-mutant mice with null that are Areg and homozygous for the Egfr wa2 allele (...

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Relationships between follicular fluid steroid hormone concentrations, oocyte maturity, in vitro fertilization and embryonic development in the rhesus monkey

Cited by 38 publications

References 36 publications

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

Rhesus Monkey Oocyte Maturation and Fertilization in Vitro: Roles of the Menstrual Cycle Phase and of Exogenous Gonadotropins1

Progesterone is Essential for Maintenance of Tace/Adam17 mRNA Expression, But not EGF-like Factor, in Cumulus Cells, Which Enhances the EGF Receptor Signaling Pathway During In Vitro Maturation of Porcine COCs

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