Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

Abstract

Abstract. Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed the levels of AOPPs, estradiol (E 2 ) and progesterone (P 4 ) in the follicular fluid (FF) of 89 women with or without EM undergoing in vitro fertilization (IVF). The AOPP concentration in the FF of the EM group was significantly higher when compared with that of the control group (51.5±22.4 vs. 41.8±18.3 µmol/l; P<0.05). However, the FF P 4 levels and blastocyst rate were significantly lower in the EM group compared with the control group (P 4 :1,249.6±465.4 vs. 1,752.7±565.4 ng/ml, P<0.05; blastocyst rate: 0.511±0.322 vs. 0.662±0.278; P<0.05). The AOPP concentration and P 4 level in the FF presented a significant negative correlation in the EM and control groups, as well as in the total cohort of patients (EM group: r=-0.406, P=0.006; control group: r=-0.315, P=0.035; total: r=-0.421, P<0.001). In addition, there was a significant negative correlation between the FF AOPP concentrations and blastocyst rate in the EM group and in the total cohort (EM group: r=-0.376, P=0.012; total: r=-0.367, P<0.001). In conclusion, these results suggested that AOPPs may be a potentially effective marker for predicting the oocyte quality and outcomes of IVF in infertile women with EM.

Does Endometriosis Influence the Embryo Quality and/or Development? Insights from a Large Retrospective Matched Cohort Study

“…The group of Song and colleagues have demonstrated that the number of mature follicles and good embryos, and fertilization and blastulation rates were reduced in women with endometriosis compared with women with a male factor indication [15]. In line with our results, Benaglia and colleagues found that, in women with bilateral endometriomas, despite the lower number of oocytes retrieved, no differences could be observed in terms of fertilization rate, number of embryos obtained and rate of top-quality embryos per oocyte used compared to controls without the disease [16].…”

Advanced Oxidation Protein Products Induce G1/G0-Phase Arrest in Ovarian Granulosa Cells via the ROS-JNK/p38 MAPK-p21 Pathway in Premature Ovarian Insufficiency

“…Advanced oxidation protein products (AOPPs) are novel protein markers of oxidation-mediated protein damage and have been reported to accumulate in many chronic inflammatory diseases, such as chronic kidney disease [9], osteoporosis [10], and inflammatory bowel disease [11]. AOPPs are altered in the peritoneal fluid and follicular fluid of patients with endometriosis, and significant negative correlations between AOPP concentrations in follicular fluid and blastocyst rates have been observed [12][13][14]. In addition to being products of chronic oxidative stress, AOPPs can trigger oxidative stress and induce a variety of cell pathological changes, including apoptosis [15], autophagy [16], and pyroptosis [17].…”

Advanced oxidation protein products change biological behaviors of rats endometrial epithelial cells by activating ERK/P38 signaling pathways

“…In patients with uterine leiomyoma, the serum level of AOPPs increases and the antioxidant capacity decreases (Santulli et al, 2013). In peritoneal fluid and follicular fluid of endometriosis, the level of AOPPs is also extraordinarily high (Santulli et al, 2015;Song et al, 2018). These observations suggest that AOPP accumulation has a close relationship with endometriosis, but it remains unknown whether AOPPs affect biological characteristics of EECs.…”