Relationships among Serum CA15-3 Tumor Marker, TNM Staging, and Estrogen and Progesterone Receptor Expression in Benign and Malignant Breast Lesions

Atoum, Manar; Nimer, Nisreen; Abdeldayem, Sawsan; Nasr, Hamzah

doi:10.7314/apjcp.2012.13.3.857

Cited by 22 publications

(20 citation statements)

References 31 publications

(30 reference statements)

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“…CA15-3 is elevated in 69% of the cases of HR+/ Her2-primary tumors (Bensouda et al, 2009). This correlation was also confirmed by Atoum et al, where CA15-3 was elevated in 54.2% of ER+/PR+ breast tumors (Atoum et al, 2012). This serum marker may be useful in therapeutic decisions when more correlation is established between CA15-3 and ER/ PR/Her2 status.…”

Section: Biological Markers On Moroccan Patientssupporting

confidence: 72%

Breast Cancer in Morocco: A Literature Review

Slaoui¹,

Rachid²,

Ibrahimi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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In Morocco, breast cancer is the most prevalent cancer in women and a major public health problem. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. It is therefore interesting to establish the genetic and molecular profile of Moroccan patients with breast cancer. In this paper, we will highlight some pertinent hypotheses that may enhance breast cancer care in Moroccan patients. This review will give a precise description of breast cancer in Morocco and propose some new markers for detection and prediction of breast cancer prognosis.

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Section: Biological Markers On Moroccan Patientssupporting

confidence: 72%

Breast Cancer in Morocco: A Literature Review

Slaoui¹,

Rachid²,

Ibrahimi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This is consistent with a prior study [17] in men and women, suggesting that the effect is not explained solely by higher estrogen levels in obese postmenopausal women. An additional small study ( n < 50) reported no significant association between BMI and circulating CA15.3 [40]. However, the analysis was limited to comparisons between obese vs. non-obese (BMI ≥30 vs. <30).…”

Section: Discussionmentioning

confidence: 99%

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

et al. 2017

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BackgroundOvarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.MethodsWe evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression.ResultsCA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination.ConclusionsThis study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-017-0315-6) contains supplementary material, which is available to authorized users.

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“…On the other hand, linear regression analysis of the and Atoum et al, 2012 reported that estrogen receptor status is strongly correlated with elevated CA15-3 level. Generally, colon cancer procreates a protein identified as Carcinoembryonic Antigen or CEA (Compton et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Moazzezy¹,

Farahany²,

Oloomi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: CEA and CA 15.3 serum tumor markers are currently used in clinical practice for monitoring therapy. The aim of this study was to evaluate serum level of these markers among healthy females and invasive breast carcinoma (IBC) patients and to determine any relationships with clinicopathological factors. Materials and Methods: 60 Iranian females were enrolled in this study, 30 healthy and 30 diagnosed with breast cancer who had not received any preoperative chemotherapy or hormone therapy. Enzyme linked immunosorbent assays were used for the quantitative determination of the cancer associated antigens, CEA and MUC1 (CA15-3). Results: The serological levels of CEA and CA15-3 (5.0033±0.49 µg/L and 178.1667±15.11 U/ml) in the breast cancer patients were significantly higher (p=0.00) than the serum levels of normal controls (1.1237±0.11 µg/L and 21.13±3.058 U/ml). Regarding the CEA marker, a significant correlation with grade of tumor was shown. Furthermore, there was a low correlation between CA15-3 and CEA marker with correlation coefficient r=0.08. Conclusions: Collectively, markedly high levels of CEA and CA15-3 were found in our patients, pointing to their use as additional tools after clinical diagnosis.

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Relationships among Serum CA15-3 Tumor Marker, TNM Staging, and Estrogen and Progesterone Receptor Expression in Benign and Malignant Breast Lesions

Cited by 22 publications

References 31 publications

Breast Cancer in Morocco: A Literature Review

Breast Cancer in Morocco: A Literature Review

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

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