Relationship of Serum Adiponectin and Leptin Concentrations with Body Fat Distribution in Humans

Staiger, Harald; Tschritter, Otto; Machann, Jürgen; Thamer, Claus; Fritsche, Andreas; Maerker, Elke; Schick, Fritz; Häring, Hans‐Ulrich; Stümvoll, Michael

doi:10.1038/oby.2003.48

Cited by 222 publications

(165 citation statements)

References 24 publications

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“…In another study, fasting serum adiponectin was found not to correlate with hip circumference independently of gender and body fat percent in a mixed population of men and women, although it correlated inversely with WHR. 40 Combined with the present results, this indicates that lower-body fat rather than other factors associated with hip circumference is responsible for variations in plasma adiponectin levels.…”

Section: Discussionsupporting

confidence: 82%

Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin

et al. 2005

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AIMS:To study the association between lower-body fat and estimates of whole-body insulin sensitivity in middle-aged men with and without a history of juvenile onset obesity, and to determine the possible mediating role of fasting serum adiponectin level as an insulin-sensitizing peptide. METHODS: A total of 401 men aged 39-65 y, body mass index 18-54 kg/m 2 , participated in the study. The following variables were measured on the study participants: regional body fat distribution as assessed by dual energy X-ray absorptiometry, abdominal sagittal diameter, maximal oxygen uptake (VO 2 max), physical activity, fasting and post-glucose load levels of plasma glucose, serum insulin, and blood non-esterified fatty acid plus fasting levels of serum adiponectin and HbA1c. RESULTS: Lower-body fat mass was positively associated with insulin sensitivity as estimated by Matsudas index also after adjusting for age, lean tissue mass, trunkal fat mass, weight changes since draft board examination, VO 2 max and the level of physical activity. In a subgroup of men selected for a large lower-body fat mass, fasting serum insulin concentration was 24% lower (Po0.01) and fasting serum adiponectin 33% higher (Po0.005) compared to a subgroup of men with a small lower-body fat mass but with similar trunkal fat mass. CONCLUSION: Lower-body fat mass is positively associated with an estimate of insulin sensitivity independently of trunkal fat mass in both lean and obese middle-aged men and this effect could partly be statistically explained by variations in serum adiponectin levels.

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Section: Discussionsupporting

confidence: 82%

Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin

et al. 2005

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“…Th ey have performed analysis of several obesity studies and plasma adiponectin levels in healthy adults and rejected a hypothesis that obesity may independently aff ect plasma adiponectin. Th e insignifi cant negative eff ect of WHR, SCWBF, and WC in predicting adiponectin concentration (shown in Table 3) is in agreement with the study being done to investigate the relationship of serum adiponectin concentrations with body fat distribution which reported a negative correlation between WHR as well as WC and adiponectin (Staiger et al 2003). Our fi ndings indicate that BMI, WF, VF, and SCWBF are poor predictors for the considering of the salivary adiponectin concentrations in the healthy adult males.…”

Section: Discussionsupporting

confidence: 79%

“…Some studies have reported a signifi cant association between the adiponectin level with BMI and the fat distribution (Staiger et al 2003;Goropashnaya et al 2009). However, a lack of association of adiponectin with BMI has been also reported by others (Kuo and Halpern 2011).…”

mentioning

confidence: 99%

Salivary adiponectin concentration in healthy adult males in relation to anthropometric measures and fat distribution

Abdalla

Soon

2017

Endocrine Regulations

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Objectives. Body fat content, fat distribution, and adiponectin level are important variables in the development of obesity related complications. Anthropometric indices may provide an economic and faster method in measuring the risk for complications through their predictive eff ect of fat distribution and adiponectin concentration. We aimed to determine, which of the waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI) may be the best predictor for the total fat percentage (WF), visceral fat level (VF), and subcutaneous whole-body fat (SCWBF). We aimed also to investigate the potential use of the anthropometric measures and fat distribution as predictors for the salivary adiponectin level in the healthy adult males.Subjects. A total of 88 adult males aged between 18−25 years with a wide range of BMI were studied. Anthropometric indices were measured using standardized methods and salivary adiponectin level was assessed using an enzyme-linked immunosorbent assay.Results. In path analysis of the Structural Equation Model (SEM) using IBM@SPSS AMOS, version22, BMI and WC, but not WHR, were strong predictors for WF and SCWBF (p<0.05). BMI but not WC was a strong predictor for VF (p<0.001). WF was strong predictor for SCWBF (p<0.001), but not for VF. BMI, WC, WHR, WF, VF, and SCWBF were poor predictors of the salivary adiponectin level.Conclusion. BMI is the best predictor for the total body fat and fat distribution. However, WHR seems to be of a little value and the salivary adiponectin level independent of BMI and body fat in healthy adult Malay males.

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“…17 We assessed the impact of two common ADIPOQ variants (located in the 5 0 region) on corpulence and body fat distribution in a large cohort of 837 unrelated middle-aged French subjects that were prospectively followed up for 7 years.…”

Section: Discussionmentioning

confidence: 99%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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Background: Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies. Objective: The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices. Design: Two adiponectin gene (ADIPOQ) SNPs, À11391G4A and À11377C4G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period. Results: For À11391G4A as well as for À11377C4G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the À11391A (P ¼ 0.02) and À11377C (P ¼ 0.03) allele over the follow-up of the study. À11391G4A and À11377C4G define haplotypes associated also with WHR measurements and their changes over the followup of the study. Diploid configurations that combine À11391A and À11377C were associated with significantly higher WHR changes (DCE: P ¼ 0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (Po0.0001). Conclusion: In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

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Relationship of Serum Adiponectin and Leptin Concentrations with Body Fat Distribution in Humans

Cited by 222 publications

References 24 publications

Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin

Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectin

Salivary adiponectin concentration in healthy adult males in relation to anthropometric measures and fat distribution

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

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