Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Abstract

Background: Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies. Objective: The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices. Design: Two adiponectin gene (ADIPOQ) SNPs, À11391G4A and À11377C4G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period. Results: For À11391G4A as well as for À11377C4G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the À11391A (P ¼ 0.02) and À11377C (P ¼ 0.03) allele over the follow-up of the study. À11391G4A and À11377C4G define haplotypes associated also with WHR measurements and their changes over the followup of the study. Diploid configurations that combine À11391A and À11377C were associated with significantly higher WHR changes (DCE: P ¼ 0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (Po0.0001). Conclusion: In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

Effect of interaction betweenPPARG,PPARAandADIPOQgene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study

“…The + 276G allele was associated with higher BMI in Italians (116) but with lower BMI in Swedish and African Americans (120,121) . Higher waist : hip ratio was found in carriers of the -11391A allele (122) and there are reports of increased risk of insulin resistance and type 2 diabetes associated with the -11391 G/G genotype (105,109) .…”

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

“…6,17 Currently, a limited number of cohort studies evaluated associations between genetic variation in candidate genes and waist. [18][19][20] In the last decade, it became feasible and affordable to analyze a large number of single nucleotide polymorphisms (SNPs) simultaneously. Genome-wide association studies, a hypothesis-free approach to find genetic areas associated with a trait, identified associations between genetic variations in the INSIG2, FTO, CTNNBL1 and MC4R gene and obesity.…”

Однонуклеотидні Поліморфізми Гена Адипонектину У Хворих На Цукровий Діабет 2-Го Типу Та Неалкогольну Жирову Хворобу Печінки

“…If there was a genotype -11391A and 11377C, WHR was significantly higher compared to other haplotypes. Also AC/AC-haplotype carriers had higher levels of adiponectin than the carriers of GG/GG-haplotype (p < 0.0001) [47].…”