Relationship of posture and age to urinary protein excretion.

Mahurkar, Sakharam D.; Dunea, George; Pillay, Veerasamy K. G.; LeVine, Harry; Gandhi, V C

doi:10.1136/bmj.1.5960.712

Cited by 12 publications

(7 citation statements)

References 7 publications

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“…Seveml factors affect the protein excretion under normal conditions: e.g., effort (21), stress (ls), body position (23). There is a weak correlation between age and excretion (13). This opinion is supported by our study.…”

Section: Discussionsupporting

confidence: 88%

Studies on Kidney Function in Subjects Exposed to Organic Solvents

Askergren¹,

Allgén²,

Karlsson³

et al. 1981

Journal of Internal Medicine

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ABSTRACT. The urine of 134 subjects, exposed to different organic solvents, and 48 unexposed subjects has been analysed with reference to albumin and β‐2‐microglobulin excretion. The exposed subjects excreted significantly larger quantities of albumin than the unexposed. Those exposed to styrene excreted the largest amounts. No significant difference in β‐2‐microglobulin excretion could be demonstrated between the groups.

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Section: Discussionsupporting

confidence: 88%

Studies on Kidney Function in Subjects Exposed to Organic Solvents

Askergren¹,

Allgén²,

Karlsson³

et al. 1981

Journal of Internal Medicine

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“…This was matched by diurnal changes in CrCl. Whereas all children had a higher upright CrCL compared with supine CrCl, this increase was much greater in those with OP, supporting the idea that hemodynamic factors play a role in diurnal protein excretion and OP [19]. …”

Section: Discussionmentioning

confidence: 62%

“…Previous studies have reported OP in 2–5% of children or young adults with asymptomatic proteinuria [3, 19, 20]. OP often resolves in adulthood, but even when it persists, it rarely indicates significant renal disease [20–22].…”

Section: Discussionmentioning

confidence: 99%

Orthostatic proteinuria and the spectrum of diurnal variability of urinary protein excretion in healthy children

et al. 2010

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The aim of this study was to characterize the 24-h and diurnal variability of urinary protein excretion and identify the prevalence of orthostatic proteinuria (OP) in healthy children. Upright, supine, and 24-h total urinary protein (UrTP) and creatinine clearance (CrCl) were measured in 91 healthy children ages 6–19 years. Urinary protein and creatinine excretions were calculated and examined by gender, age, Tanner stage, and body mass index (BMI). Orthostatic proteinuria (OP) was defined as a 24-h UrTP >100 mg/m2 with a normal supine UrTP (<4 mg/m2/h). There exists a marked diurnal variability in UrTP. The upright UrTP rate was three to four-times greater than the supine rate. UrTP, adjusted for body surface area, is higher in boys than girls and increases with age and BMI. There is a similar increase in upright CrCl compared with supine. Urinary protein to creatinine ratio (UPcr) is strongly correlated with UrTP. OP is common, being found in 20% of children in this cohort, and is more common in boys and associated with age >10 years and BMI >85%. In children with OP, a first morning UPcr shows a value in the normal range, whereas a random daytime UPcr is elevated. There exists a diurnal variability in urinary protein excretion that is exaggerated in participants with OP. UPcr reliably estimates 24-h UrTP. Using current pediatric criteria, OP is very common, particularly in boys. A normal first morning UPcr ratio indicates that a child with elevated random urinary protein has OP.

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“…[4][5][6] The prevalence of OP had been thought to be between 2.5% and 5%. 4,7,8 In a preliminary publication, we recently reported that among 2889 healthy adolescents aged 10 to 18 years screened for proteinuria, 9.8% showed midday urine protein 1+ or more on dipstick. 4 However, when quantified, only 3.6% had protein/ creatinine ratio >0.20 mg/mg.…”

Section: Discussionmentioning

confidence: 99%