Relationship between Vitamin D Receptor Gene Polymorphisms, Cardiovascular Risk Factors and Adiponectin in a Healthy Young Population

Hajj, Aline; Chedid, Rima; Chouery, Éliane; Mégarbané, André; Gannagé‐Yared, Marie‐Hélène

doi:10.2217/pgs-2016-0045

Cited by 32 publications

(26 citation statements)

References 47 publications

(30 reference statements)

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“…The males carrying the AA genotype of BsmI had a 2.63-fold higher risk of FMF (OR: 2.63; 95% CI: 1.12-6.01) compared to the males carrying the GG or AG genotypes. This finding is not in agreement with the results of Kizildag et al [29], but several other studies reported sex-related differences in the distribution of BsmI genotypes [30][31][32]. For example, Bodoki et al [30] showed significantly different distributions of BsmI genotypes between male and female patients with idiopathic inflammatory myopathy [30].…”

Section: Discussioncontrasting

confidence: 55%

“…Different genotype frequencies of BsmI have also been observed between male and female patients with Graves' disease [31]. Finally, the AA genotype of BsmI polymorphism has been associated with higher body mass index, higher waist circumference, and lower adiponectin levels in randomly selected healthy men [32]. In the study of Dogan et al [3], no significant difference was observed between male and female patients with FMF in the rate of heterozygous and homozygous mutations of MEFV gene [3].…”

Section: Discussionmentioning

confidence: 98%

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Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever

Turhan

Doğan

Boğdaycıoğlu

et al. 2017

Bosn J of Basic Med Sci

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Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF patients and 105 controls. Seventy patients had no attack (group 1), 30 had 1-2 attacks (group 2), and 23 had 3 or more attacks (group 3) within last three months. Serum 25(OH)D3 concentrations were determined using liquid chromatography-tandem mass spectrometry. BsmI, FokI, and TaqI polymorphisms were analyzed by a competitive allele specific polymerase chain reaction assay (KASPar). Serum lipid parameters were measured with enzymatic colorimetric methods. 25(OH)D3 concentrations were lower in FMF patients compared to controls (p < 0.001). No difference was observed in 25(OH)D3 concentration between groups 1, 2, and 3. The distributions of FokI and TaqI genotypes were not significantly different between FMF patients and controls. There was a significant difference in the distribution of AA BsmI genotype between male FMF patients and male controls. Increased concentrations of triglycerides (p = 0.012) and decreased concentrations of high-density lipoprotein cholesterol [HDL-C] (p = 0.006) were found in FMF patients compared to controls. Although lower 25(OH)D3 concentrations were observed in FMF patients versus controls, no association was determined between FMF attack frequency and 25(OH)D3 concentrations. We showed that the AA genotype of BsmI polymorphism is associated with FMF in males but not in females. The effects of decreased HDL-C and increased triglyceride concentrations on cardiovascular events in FMF patients should be further investigated.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 98%

Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever

Turhan

Doğan

Boğdaycıoğlu

et al. 2017

Bosn J of Basic Med Sci

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“…This study revealed no significant difference of vitamin D status between females and males This is in conformity with results of a systematic review of vitamin D status in populations worldwide which did not reveal any substantial gender-related differences in vitamin D status, except in the Middle East and Asia, probably due to the dressing code of females in these regions [ 24 , 25 ]. Contrarily, a study in Lebanon revealed that females had significantly higher vitamin D levels than males [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Its Associated Risk Factors among Adults in the Southwest Region of Cameroon

Tangoh

Apinjoh

Mahmood

et al. 2018

Journal of Nutrition and Metabolism

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Background Vitamin D has been shown to exert its actions on the musculoskeletal, gastrointestinal, prostate, renal, endocrine, immune, and cardiovascular systems. Current reported data of hypovitaminosis D reveals a global pandemic, with an estimated one billion people worldwide presenting with hypovitaminosis D. Objective This study aimed at investigating the vitamin D status and its associated risk factors in Cameroonians from the South West Region. Method The study was a community- and hospital-based prospective longitudinal study. It was carried out during the dry and rainy seasons between the months of July and December 2015 in the South West Region of Cameroon involving 372 participants aged 35 years and above. After obtaining informed consent, a structured questionnaire was used to capture demographic data and risk factors of vitamin D deficiency. Blood samples were collected from the volunteer participants in the peak months of the rainy season and dry season, and the serum used to analyse for vitamin D by ELISA and calcium by spectrophotometry. 25(OH)D levels ≥75 nmol/L (≥30 ng/mL) were considered sufficient while levels <75 nmol/L were considered as hypovitaminosis D (insufficiency/deficiency). Results Hypovitaminosis D (deficiency/insufficiency) was prevalent in 25.8% (96) of the study population, with only 3.2% (12) deficiency and 22.6% (84) insufficiency. There was a significant inverse relationship (r=−0.119, p=0.02) between age and 25(OH)D levels; however, this relationship was not significant when controlled for gender, number of hours spent outdoors, and percentage of body covered. Gender, ethnic origin, percentage of body covered, time spent outdoors, and season did not influence serum vitamin D levels. Conclusion Results of this study suggest that the prevalence of hypovitaminosis D is relatively low in this study population and only age is a risk factor of vitamin D deficiency.

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“…DNA sequences were obtained from UCSC or Genbank databases. The primers used for the study, which were ApaI, Cdx2, BmsI, TaqI, and FokI SNPs, were the same as those used respectively by Hajj et al [28]. The PCR products were verified using 1% agarose gel con-taining SYBR ® Safe (Life Technologies, CA, USA).…”

Section: Rflp-pcrmentioning

confidence: 99%

FokI vitamin D receptor gene polymorphism and serum 25-hydroxyvitamin D in patients with cardiovascular risk

Nakhl

Sleilaty

Chouery

et al. 2019

Arch Med Sci Atheroscler Dis

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Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR). Numerous single-nucleotide polymorphisms (SNPs) in the VDR gene have been identified, and some have been associated with cardiovascular disease (CVD) risk factors. This study aims to evaluate the association of five SNPs in the VDR gene with 25-hydroxyvitamin D (25[OH]D) levels in patients with at least one CVD risk factor. Material and methods: Genomic DNA was sequenced using standard Sanger methods for five VDR SNPs (BsmI rs1544410; ApaI rs7975232; Cdx2 rs11568820; TaqI rs731236; FokI rs2228570) in 50 Mediterranean subjects having hypovitaminosis D with at least one documented CVD risk factor, aged 18 years or more. The collected variables were serum levels of (25[OH]D), HbA 1c , fasting plasma glucose, triglycerides, LDL cholesterol, and total cholesterol. Results: BsmI, ApaI, and TaqI were moderately to highly intercorrelated. Cdx2 was less frequent than expected. With respect to the number of mutations in FokI, levels of (25 [OH]D) were 11.2 ±5.5 ng/ml in the absence of mutations, 12.6 ±4.7 ng/ml in the presence of one mutation, and 16.5 ± 5.5 ng/ml in the presence of two mutations. Conclusions: FokI polymorphism is more frequent in subjects with cardiovascular risk factors than in the general Caucasian population.

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Relationship between Vitamin D Receptor Gene Polymorphisms, Cardiovascular Risk Factors and Adiponectin in a Healthy Young Population

Abstract: Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.

Cited by 32 publications

References 47 publications

Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever

Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever

Vitamin D Status and Its Associated Risk Factors among Adults in the Southwest Region of Cameroon

FokI vitamin D receptor gene polymorphism and serum 25-hydroxyvitamin D in patients with cardiovascular risk

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