Relationship between the Serum Level of Leptin and Life-Style Habits in Japanese Men

Togo, Mio; Hashimoto, Yasuo; Futamura, Azusa; Tsukamoto, Katsumi; Satoh, Hidetoshi; Hara, Manami; Watanabe, Tomofumi; Nakarai, Hideo; Nakahara, Kazuhiko; Kimura, Seiji

doi:10.1159/000053254

Cited by 13 publications

(16 citation statements)

References 51 publications

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“…Finally, although body fat mass is the most important variable that controls circulating leptin and adiponectin, there is great heterogeneity in the concentrations of these adipokines at any given level of body fat, and differences between populations may contribute to the discrepant results from different populations. In support of this, the relationship between leptin and smoking has been found to be different in different populations [1,15,16,26] .…”

Section: Discussionmentioning

confidence: 90%

“…However, despite its association with weight reduction and known association between smoking cessation and weight gain, studies on the association between smoking and adipokines have often yielded conflicting results. For example, with regard to leptin, the main adipokine regulating body weight, studies have often shown contradictory results with some studies showing a decrease [1,[12][13][14]] , no effect [15,16] or even an increase [17] . We had shown in a previous study that smoking sheesha and cigarettes have adverse metabolic effects [18] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Smoking Habit on Circulating Adipokines in Diabetic and Non-Diabetic Subjects

Mutairi¹,

Mojiminiyi²,

Shihab-Eldeen³

et al. 2008

Ann Nutr Metab

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Background: Despite the well-known inverse association between smoking and body weight, there have been conflicting reports on the association between smoking and adipokines such as leptin and adiponectin. Aim: To determine and compare whether tobacco smoking (cigarettes or sheesha) affects circulating levels of adiponectin and/or influences leptin and leptin receptor (sOb-R) concentrationsand free leptin in diabetic and non-diabetic subjects. Methods and Subjects: Fasting plasma adiponectin, leptin, sOb-R, glucose, insulin, and lipid profile were determined in 236 subjects grouped as control subjects (n = 53); non-diabetic cigarette smokers (n = 34), non-diabetic sheesha smokers (n = 38), diabetic nonsmokers (n = 75) and diabetic smokers (n = 36). Uni- and multivariate regression analyses were used to determine the associations of these variables with body mass index (BMI) and smoking. Results: When compared to control subjects, smoking cigarettes or sheesha was associated with significantly higher glucose, insulin resistance, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and lower serum leptin, sOb-R and free leptin. The effects of smoking on BMI, leptin and sOb-R were dose-dependent. Binary logistic regression analysis showed that smoking is a significant determinant of BMI; leptin, sOb-R, free leptin index, adiponectin and LDL-C. Conclusions: We conclude that smoking sheesha does not reduce the metabolic effects of smoking. Smoking may modify leptin receptors and modulate leptin synthesis but the weight-lowering effect may not be related to leptin-induced anorectic signals.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effect of Smoking Habit on Circulating Adipokines in Diabetic and Non-Diabetic Subjects

Mutairi¹,

Mojiminiyi²,

Shihab-Eldeen³

et al. 2008

Ann Nutr Metab

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“…Mild to moderate leukocytosis is common among SCA patients and this has been attributed to re-distribution of leukocytes from marginal pool to a systemic pool of granulocytes, while moderate lymphocytosis and monocytosis have been implicated as markers of inflammation in SCA patients [1,2,4,47,48]. A study by Wilson et al [50] revealed a positive correlation between leptin level and WBC count, while Togo et al [51] showed that leptin associates negatively with haemoglobin. In this study, we did not find significant correlation between leptin and these haemotological parameters.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of leptin in Nigerian patients with sickle cell anaemia

Iwalokun

Iwalokun²,

Hodonu

et al. 2011

BMC Hematol

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BackgroundSeveral studies have shown that the pathophysiology of homozygous sickle cell anaemia (SCA) results in a myriad of metabolic, nutritional, haematological and clinical effects that interact with other co-morbid factors to determine the quality of life and life expectancy of afflicted patients. Because of its critical roles in nutrition and metabolism, inflammation, haematopoiesis and cellular immunity, this study determined the plasma levels of leptin in steady and unsteady states of HbSS in Nigerian patients.MethodsA total of 51 SCA patients aged 5 - 35 years with 34 (61.8%) being females who were either on admission or visiting four medical centres in Lagos, Nigeria together with 22 non-SCD controls aged 5 -30 years comprising 12 (54.5%) females were enrolled after obtaining their informed consent and ethical approval. Patients were further stratified into steady and unsteady cases of SCA based on clinical presentations, while blood samples collected by venipuncture from each of the study participants were analyzed haematologically for full blood count and HbF level and microscopically for malaria, while plasma leptin was assayed using ELISA method. Body composition defined by weight, fat mass and body mass index (BMI) was determined using standard methods. Data obtained for cases and controls were analyzed statistically.ResultsTwenty - one patients had unsteady HbSS and elicited greater and significant (P < 0.05) reduction in fat mass, BMI, HbF and eosinophil count but elevated mean total leukocyte, count, level of irreversibly sickled cells and P. falciparum parasitaemia (4613.7 vs. 749.6 - 1078.4 parasites/uL), pyrexia rate (58.3 vs. 25.8%) when compared with steady state patients or non-SCD controls. Compared to the control, significant decreases in plasma leptin before and after controlling for body fat that was worsened by crisis were observed among the SCD patients. Unlike the non-SCD controls, leptin correlated non-significantly (P > 0.05) with all body composition indices measured in the patients except for fat mass in unsteady cases. Multivariate regression analysis identified ESR and RC as independent predictor of low plasma leptin concentration in the SCA patients.ConclusionsBase on these findings, we conclude that plasma level of leptin is further decreased in the unsteady state of HbSS, shows poor correlation with adiposity and malarial infection but has inflammation and poor reticulocyte response as independent predictors among Nigerian patients.

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“…BMI, subcutaneous thickness, and other indicators of body fat, together with gender, clearly illustrate the differences in leptin levels (7, 8). The factors such as physical activity that reduce adipose tissue also diminish levels of leptin (9, 10, 11, 12). However, despite its association with weight reduction, tobacco consumption has shown contradictory results (9, 13, 14, 15, 16, 17).…”

Section: Introductionmentioning

confidence: 99%

“…The factors such as physical activity that reduce adipose tissue also diminish levels of leptin (9, 10, 11, 12). However, despite its association with weight reduction, tobacco consumption has shown contradictory results (9, 13, 14, 15, 16, 17). Factors such as hypertension that are associated with an increase in adipose tissue are associated with increases in the serum levels of leptin (18).…”

Section: Introductionmentioning

confidence: 99%

Leptin and Altitude in the Cardiovascular Diseases

León¹,

González²,

Méndez³

et al. 2004

Obesity Research

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CABRERA DE LEÓ N, ANTONIO, DELIA ALMEIDA GONZÁ LEZ, LINA I. PÉ REZ MÉ NDEZ, ARMANDO AGUIRRE-JAIME, MA DEL CRISTO RODRÍGUEZ PÉ REZ, SANTIAGO DOMÍNGUEZ COELLO, IRMA CARBALLO TRUJILLO. Leptin and altitude in the cardiovascular diseases. Obes Res. 2004;12:1492-1498. Objective: The lower mortality from coronary ischemic disease in populations living at high altitude has been related to an increase of high-density lipoprotein (HDL)-cholesterol at altitude. Leptin has been proposed as a cardiovascular risk factor. We investigated whether leptin varies according to the altitude at which people live. Research Methods and Procedures: This was a crosssectional study of the first 889 people enrolled in a cohort study in the Canary Islands, Spain. The relationship among serum leptin, altitude, obesity, and other cardiovascular risk factors was analyzed by bivariate and multivariate tests. Results: Leptin levels showed an inverse correlation to altitude expressed in meters (r ϭ Ϫ0.10). Obese subjects had this leptin-altitude association (r ϭ Ϫ0.19), but they also had a direct correlation of leptin to HDL-cholesterol (r ϭ 0.27) and an inverse correlation of leptin to the total cholesterol-to-HDL-cholesterol ratio (r ϭ Ϫ0.34), triglycerides (r ϭ Ϫ0.29), apolipoprotein B (r ϭ Ϫ0.21), and glycemia (r ϭ Ϫ0.19). Nonobese subjects had only the leptin-altitude association (r ϭ Ϫ0.11). The final regression model included altitude as predictor. Other associated variables were gender, physical activity, BMI, age, smoking (reducing leptin independently of BMI), alcohol, heart rate, and income.Discussion: Serum leptin level decreases when altitude increases, and this association could help to explain the lower cardiovascular mortality rate at high altitude. However, because in obese subjects there is a direct association of leptin with HDL-cholesterol and an inverse association with the lipid atherogenic fractions, we suggest the hypothesis of different roles for bound and free leptin, with free leptin being a cardiovascular protective factor in obese people.

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Relationship between the Serum Level of Leptin and Life-Style Habits in Japanese Men

Cited by 13 publications

References 51 publications

Effect of Smoking Habit on Circulating Adipokines in Diabetic and Non-Diabetic Subjects

Effect of Smoking Habit on Circulating Adipokines in Diabetic and Non-Diabetic Subjects

Serum levels of leptin in Nigerian patients with sickle cell anaemia

Leptin and Altitude in the Cardiovascular Diseases

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