Relationship between the <scp>MDS‐UPDRS</scp> domains and the health‐related quality of life of <scp>P</scp>arkinson's disease patients

Martinez‐Martín, Pablo; Rodríguez‐Blázquez, Carmen; Forjaz, Maria João; Sánchez, Mario Álvarez; Arakaki, Tomoko; Bergareche-Yarza, Alberto; Chade, Anabel; Garretto, Nélida; Gershanik, Oscar S.; Kurtis, Mónica; Martínez‐Castrillo, Juan Carlos; Mendoza-Rodriguez, Amelia; Moore, Henry; Rodríguez-Violante, Mayela; Singer, Carlos; Tilley, Barbara C.; Huang, Jing; Stebbins, Glenn T.; Goetz, Christopher G.

doi:10.1111/ene.12349

Cited by 49 publications

(47 citation statements)

References 40 publications

(102 reference statements)

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“…Our study documented a positive correlation between quality of life and quality of sleep, as previously reported in other studies [39, 40]. This occurred despite the different sleep disorders that had individually not shown a significant relationship with quality of life.…”

Section: Discussionsupporting

confidence: 91%

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

et al. 2017

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Objectives: To determine the frequency of major sleep disorders in patients with Parkinson’s disease (PD), diagnosed according to the third international classification of sleep disorders, and assess the relationship of those disorders with the quality of life. Methods: A cross-sectional study was performed involving 88 consecutive patients with PD from outpatient clinic. Participants were subjected to clinical interviews, assessment using standardized scales (Epworth Sleepiness Scale, PD Questionnaire, Pittsburgh sleep quality index (PSQI) and, for individuals with a diagnosis of RLS/WED, International RLS/WED grading scale), and video-polysomnography. Results: We observed sleep disorders in 96.5% of the participants, with REM-sleep behavior disorder found in 62.5%, obstructive sleep apnea in 62.5%, insomnia in 55.7%, and restless legs syndrome in 28.4%. We observed a correlation between health-related quality of life with the PSQI and the Epworth sleepiness scale. Conclusion: Patients with PD have a high prevalence of sleep disorders. The quality of sleep and excessive daytime sleepiness significantly affect the quality of life in these individuals.

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Section: Discussionsupporting

confidence: 91%

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

et al. 2017

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“…As treatment options became more helpful for motor symptoms of IPD, NMS became important for HRQoL measurements [3]. Fatigue was reported as an important factor which affects HRQoL by itself or with other NMS [23].…”

Section: Neurol Scimentioning

confidence: 99%

“…Both motor and NMS are important to measure HRQoL in IPD [3]. We usually focus on motor symptoms, but NMS are sometimes more devastating than motor ones.…”

Section: Introductionmentioning

confidence: 99%

Independent effect of fatigue on health-related quality of life in patients with idiopathic Parkinson’s disease

et al. 2015

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Nonmotor symptoms (NMS) of idiopathic Parkinson's disease (IPD), specifically fatigue, depression and sleep disturbances, are important contributors for worse quality of life and poor patient outcomes. The aim of this research is to determine the relationship between fatigue and other NMS and the independent effect of fatigue on health-related quality of life (HRQoL) in patients with IPD. 86 IPD patients and 85 healthy individuals were included in our study. Participants were evaluated by their answers to the Beck Depression Inventory, Fatigue Severity Scale, Epworth Sleepiness Scale and Parkinson's Disease Questionnaire-39. Hoehn-Yahr stage, disease duration, medications and demographical characteristics were also noted. ROC analysis was used to determine the cutoff point for HRQoL. Nonparametric Spearman correlation analysis was used for determining the relationship between variables. Independent factors which affect HRQoL were detected by multiple forward stepwise logistic regression analysis. NMS were associated with each other and with HRQoL when they act concomitantly (p < 0.001). Of these three frequent NMS, depression (p < 0.05) and fatigue (p < 0.001) had independent worsening effect on HRQoL, whereas sleep disturbances did not (p > 0.05). The stage of IPD and levodopa-entacapone treatment had independent effects on HRQoL too (p < 0.05). Fatigue was found as the most important factor which affects HRQoL among all investigated NMS. So, it is important to ask about fatigue in routine controls of IPD patients and try to treat it for improving life quality.

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“…With respect to the first research question, we found a slightly lower frequency of motor complications in our patients than several other studies (approximately 20% of our study participants with either of the motor complications vs. more than 22% of motor fluctuations and more than 26% of dyskinesias in other studies) (Nicoletti et al., 2016; Yoritaka et al., 2013; Martínez‐Martín et al., 2014; Hashim et al., 2014; Larsen et al., 2000; Schrag & Quinn, 2000). It is possible that the somewhat lower frequency of motor complications was partly due to the profile of the study participants.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the findings of various observational surveys using different study designs, the frequency of dyskinesias ranges from 26% to 44% and that of motor fluctuations from 22% to 64% (Nicoletti et al., 2016; Yoritaka et al., 2013; Martínez‐Martín et al., 2014; Hashim et al., 2014; Larsen, Karlsen, & Tandberg, 2000; Schrag & Quinn, 2000). Several studies have shown the prevalence of motor complications to increase with the duration of the disease (Nicoletti et al., 2016; Hashim et al., 2014; Schrag & Quinn, 2000; Scott, Macleod, & Counsell, 2016; García‐Ruiz, Del Val, Fernández, & Herranz, 2012; Stocchi et al., 2014).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with motor complications in Parkinson's disease

et al. 2017

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ObjectivesLevodopa is the most effective therapy for treating Parkinson's disease (PD); however, side effects such as dyskinesias and motor fluctuations may occur after some years of its usage. The aims of this study were to assess the frequency of and factors associated with motor complications among PD patients on levodopa treatment.MethodsIn a cross‐sectional study carried out in 2010–2013, clinical data and treatment details were collected. Logistic regression expressed by odd ratios (OR) and 95% confidence intervals (CI) was conducted to examine the effects of several independent variables on the occurrence of motor complications.ResultsA total of 455 patients were enrolled, among whom 374 were on levodopa. Analysis was performed in 328 patients whose exact duration of levodopa treatment was known. Among patients included in the analysis, 25.9% experienced motor complications; of these, 21% had dyskinesias and 20.1% had motor fluctuations. Based on logistic regression, statistically significant factors associated with the occurrence of motor complications were younger age at onset of the disease, higher levodopa equivalent daily dose (LEDD), shorter time to levodopa initiation, and akinetic‐rigid dominant phenotype of PD.ConclusionsThis study suggests that postponing the start of levodopa therapy and maintaining low daily doses of levodopa might reduce the risk of motor complications. Our results confirm that due to higher risk of motor complications, effectively treating patients with akinetic‐rigid dominant phenotype of PD might be more challenging than for patients whose dominant symptom is tremor.

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Relationship between the MDS‐UPDRS domains and the health‐related quality of life of Parkinson's disease patients

Abstract: The MDS-UPDRS component most tightly related with the HRQoL measures was a combination of motor and non-motor experiences of daily living.

Cited by 49 publications

References 40 publications

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

Independent effect of fatigue on health-related quality of life in patients with idiopathic Parkinson’s disease

Factors associated with motor complications in Parkinson's disease

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