High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

Sobreira-Neto, Manoel Alves; Pena-Pereira, Márcio Alexandre; Sobreira, Emmanuelle Silva Tavares; Chagas, Marcos Hortes Nisihara; Fernandes, Regina Maria França; Tumas, Vítor; Éckeli, Alan Luiz

doi:10.1159/000481939

Cited by 58 publications

(44 citation statements)

References 35 publications

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“…Quality of life is altered in PD, and particularly in patients with ID (Sobreira‐Neto et al, ). We documented that CBT‐i has positive and sustained effect over time on this variable.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep disorders are probably the most common non-motor complications associated with PD, with sleep disorders noted in up to 96.5% of patients diagnosed (Sobreira-Neto et al, 2017). More specifically, when standardized criteria are used (American Academy of Sleep Medicine, 2014;American Psychiatric Association, 2013), it is estimated that more than half of patients with PD suffered from insomnia disorder (ID) with deleterious effects on quality of life (Sobreira-Neto et al, 2017). ID is therefore a common non-motor complication which warrants particular attention in PD (Uhlig, Sand, Ødegård, & Hagen, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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Objective To test the efficacy of cognitive behavioral therapy for insomnia (CBT‐i) in Parkinson's Disease (PD) and to evaluate its impact on indices of daytime and psychological functioning. Method Fifteen patients with insomnia disorder (ID) comorbid to PD were enrolled in a single‐case design with multiple baselines. Total wake time, sleep efficiency, and daytime sleepiness were recorded on a sleep diary. Self‐reported measures of insomnia, anxiety and depressive symptoms, health‐related quality of life, and psychological variables perpetuating ID were completed. All patients also underwent a clinical interview for ID diagnosis. Results CBT‐i was associated with significant changes in sleep variables and ID criteria. Significant positive treatment‐related effects were also noted for all indices of daytime and psychological functioning, and for variables perpetuating ID. All of these improvements were well maintained at 3‐month follow‐up. Conclusion CBT‐i is a promising therapeutic avenue for patients with PD.

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“…Quality of life is altered in PD, and particularly in patients with ID (Sobreira‐Neto et al, ). We documented that CBT‐i has positive and sustained effect over time on this variable.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

et al. 2019

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“…Sleep disorders are also prevalent in PD and can occur at any stage of the disease . It affects up to two‐thirds of the patients, and they are often associated with impairment in quality of life . PD patients may present with many different sleep disorders, including insomnia, REM sleep behavioral disorder (RBD), obstructive sleep apnea (OSA), and restless legs syndrome (RLS) …”

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confidence: 99%

Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease

Sobreira

Sobreira-Neto

Pena-Pereira

et al. 2019

Psychiatry Clin Neurosci

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Aim Sleep disorders can be associated with an increased risk for cognitive decline in patients with Parkinson's disease (PD). The aim of this study was to examine the association between cognitive status and presence of sleep symptoms and sleep disorders in PD patients. Methods We evaluated excessive sleepiness, other sleep symptoms, and performed polysomnography and neuropsychological evaluation in 79 patients. They were classified as having normal cognition (PDNC), mild cognitive impairment (PDMCI), or dementia (PDD). Results There were 29 PDNC, 39 PDMCI, and 11 PDD patients. PDD patients were older, had higher scores on the Unified Parkinson's Disease Rating Scale, and lower Schwab and England Activities of Daily Living scores than PDNC patients. After analysis of the polysomnographic variables, it was also found that PDD patients had a lower sleep efficiency, lower total sleep time, and lower number of sleep state changes than PDNC patients. In a stepwise analysis, defining Mattis Dementia Rating Scale scores as the dependent variable, the results were a model that selected three variables that accounted for 59% of the variation in the Mattis Dementia Rating Scale score: wake time after sleep onset, number of state changes, and schooling. Conclusion We found a significant association between global cognitive performance and wake time after sleep onset and the number of state changes during sleep measured in the polysomnography of PD patients. However, we did not find any other association between sleep disorders or symptoms and cognitive status or cognitive performance of PD patients.

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“…These sleep disorders may be present from PD's prodromal phase, may increase their presence and severity over time, and may be highly prevalent in the disease's advanced stages . Furthermore, sleep disorders in PD have been correlated with increased disease‐related disability and significant quality‐of‐life deterioration …”

mentioning

confidence: 99%

The Parkinson's Disease Sleep Scale–2 (PDSS‐2): Validation of the Spanish Version and Its Relationship With a Roommate‐Based Version

Martinez‐Martín

Wetmore

Rodríguez‐Blázquez

et al. 2019

Movement Disord Clin Pract

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Background Because of the prevalence and impact of sleep disorders in Parkinson's disease (PD), valid instruments for their evaluation and monitoring are necessary. However, some nocturnal sleep disorders may go unnoticed by patients themselves. Objectives To validate a pan‐Spanish version of the Parkinson's Disease Sleep Scale Version 2 (PDSS‐2) and to test the relationships between the PDSS‐2 and a PDSS‐2 roommate version. Methods PD patients (n = 399) from seven Spanish‐speaking countries were included. In addition to the tested PDSS‐2 scales, valid measures for sleep disorders and both motor and nonmotor manifestations were applied. Acceptability, dimensionality, reliability, precision, and construct validity were explored, as well as discrepancies and agreement between the PDSS‐2 and the roommate version. Results PDSS‐2 showed negligible floor and ceiling effects. Four factors (57% of the variance) were identified. Reliability parameters were satisfactory: alpha = 0.84; item homogeneity coefficient = 0.27; corrected item total correlation = 0.28 to 0.61; and test‐retest reliability (average kappa = 0.70; intraclass correlation coefficient [ICC] = 0.83). The standard error of measurement was 5.84, and correlations with other scales assessing nocturnal sleep were high (rS = 0.62–0.56). In comparison to the patient‐based total score, the by proxy total score showed no significant difference, high correlation (rS = 0.70), and acceptable agreement (ICC = 0.69), but there were discrepancies in two or more points in 18% of item scores. Conclusions The Spanish version of the PDSS‐2 has shown satisfactory clinimetric attributes. Acceptability and precision data are presented for the first time. The PDSS‐2 roommate version could be useful to complement the patient‐based evaluation, but additional studies are needed.

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High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

Cited by 58 publications

References 35 publications

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease

The Parkinson's Disease Sleep Scale–2 (PDSS‐2): Validation of the Spanish Version and Its Relationship With a Roommate‐Based Version

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