Relationship Between Sweat and Blood Lactate Levels During Exhaustive Physical Exercise

Abstract

In contrast to the generally accepted view, that sweat lactate is irrelevant to blood, we report on the suitability of sweat lactate for diagnostics. We demonstrate a significant increase in lactate concentration in sweat from the working muscle area simultaneously with the rise of blood lactate content during exhaustive physical exercise. The variation rates of lactate concentration in sweat from working and latent muscle areas correlate positively with blood lactate levels (r>0.8 and r=0.7, respectively), thus offering the prospect of a non‐invasive approach for the monitoring of sportsperson training. Moreover, sweat lactate, being the faster indicator of muscle metabolism, would be even more important for sports medicine than the nowadays‐used blood lactate.

Nanozyme-based electrochemical biosensors for disease biomarker detection

“…For example, blood glucose level is an indicator of diabetes: hyperglycemia and hypoglycemia, [190][191] blood lactate level can predict multiple system organ failure (MSOF) caused by septic shock 192 and ischemia and inadequate oxygenation 193 . Over the years, a number of enzyme-mimicking nanostructured materils 188,[193][194][195][196][197][198][199][200][201][202][203][204] have been used for the detection of glucose, 194-197, 202, 203 lactate, 193,[198][199]204 uric acids, 200 kanamycin, 188 and arsenet 201 . In this section, nanozyme based electrochemical sensor for glucose detection is briefly discussed.…”

Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care

“…Indeed, with specific regard to lactate, this is still a matter of huge debate. There are a significant number of published works reporting a strong correlation between lactate levels in sweat and in venous blood, [ 78 , 79 ], while there are also a number of reports that cast doubt over whether sweat lactate levels really are reflective of those in the blood, [ 80 , 81 ] and are more likely derived metabolically from blood glucose rather than from blood lactate. It is also important to note that lactate levels in sweat are somewhat higher than those seen in blood, with the biologically relevant lactate levels in sweat for a healthy individual ranging from 5 to 25 mM [ 44 , 75 ] and increasing 10-fold during physical exertion [ 82 ].…”

Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids

“…These sweat glands produce and excrete an acidic fluid directly to the outer skin surface through microscale pores [23,68]. Moreover, sweat includes various molecules, e.g., lactate [133,[138][139][140], glucose [69,134,137,141,142], cortisol [23,54,135,[142][143][144], testosterone [23], uric acid, as well as larger molecules, like proteins, peptides, and cytokines [24,54,142], Additionally, the detection of analytes in sweat is feasible due to the given correlation between the blood analyte concentration and the excreted sweat analyte concentration [138,145,146]. For analytes like hormones (cortisol, testosterone), potassium, and different drugs, e.g., alcohol, a strong sweat-blood correlation was proven [23].…”