Relationship between site of myocardial infarction, left ventricular function and cytokine levels in patients undergoing coronary artery surgery

Abstract

SummaryBackgroundThe purpose of this study was to examine the relationship between left ventricular (LV) function, cytokine levels and site of myocardial infarction (MI) in patients undergoing coronary artery bypass grafting (CABG).MethodsSixty patients undergoing CABG were divided into three groups (n = 20) according to their history of site of myocardial infarction (MI): no previous MI, anterior MI and posterior/inferior MI. In the pre-operative period, detailed analysis of LV function was done by transthoracic echocardiography.The levels of adrenomedullin, interleukin-1-beta,interleukin-6, tumour necrosis factor-alpha (TNF-α) and angiotensin-II in both peripheral blood samples and pericardial fluid were also measured.ResultsEchocardiographic analyses showed that the anterior MI group had significantly worse LV function than both the group with no previous MI and the posterior/inferior MI group (p < 0.05 for LV end-systolic diameter, fractional shortening, LV end-systolic volume, LV end-systolic volume index and ejection fraction). In the anterior MI group, both plasma and pericardial fluid levels of adrenomedullin and and pericardial fluid levels of interleukin-6 and interleukin- 1-beta were significantly higher than those in the group with no previous MI (p < 0.05), and pericardial fluid levels of adrenomedullin, interleukin-6 and interleukin-1-beta were significantly higher than those in the posterior/inferior MI group (p < 0.05).ConclusionsThe results of this study indicate that (1) patients with an anterior MI had worse LV function than patients with no previous MI and those with a posterior/inferior MI, and (2) cytokine levels in the plasma and pericardial fluid in patients with anterior MI were increased compared to patients with no previous MI.

Clinical, procedural and long-term outcome of ischemic VT ablation in patients with previous anterior versus inferior myocardial infarction

“…In those that do, though, more patients with inferior than anterior MI were included as observed in our study [7,[18][19][20][21][22][23]. A lower ejection fraction in patients with anterior infarction has been reported previously [8,12,24,25]. In line with these reports, LVEF in our cohort was significantly lower in patients with anterior MI compared to those with inferior MI.…”

“…A lower ejection fraction in patients with anterior infarction has been reported previously [ 8 , 12 , 24 , 25 ]. In line with these reports, LVEF in our cohort was significantly lower in patients with anterior MI compared to those with inferior MI.…”

Influence of Switching of Clopidogrel to Ticagrelor on the Development of Cardiovascular Events in Patients With St Segment Elevation

“…Kiris I. с со-авт. [21] на 60 больных показали, что уровни провос-палительных маркеров (ИЛ-1β, ИЛ-6, фактора некро-за опухоли) были выше после коронарного шунтиро-вания в группе пациентов с предшествующим ИМ.…”

A native extracellular matrix material for tissue engineering applications: Characterization of pericardial fluid

“…the increasing PF amount and the changes in the biochemical components are examined to deduce heart damage. [38][39][40][41] In a previous study by our research group, PF was used in tissue engineering study for the first time. Pericardial fluid structure (PFS) is the PF component that was obtained from a bovine's heart and was used for the surface modification of the polycaprolactone (PCL) scaffolds.…”