Relationship Between Serum and Saliva Chloramphenicol Concentrations

Abstract

The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 ± 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.

Concentrations of ampicillin in human serum and mixed saliva following a single oral administration of lenampicillin, and relationship between serum and mixed saliva concentrations.

“…Many attempts have been made to determine the drug concentration in saliva as a monitor of drug concentration in plasma or serum [4][5][6][7][8][9][10][11][12][13]. In comparison with blood, saliva can be obtained safely and easily.…”

“…In comparison with blood, saliva can be obtained safely and easily. However, previous studies on antibiotics have not revealed a favorable correlation between saliva and serum [4,5,[9][10][11][12][13], partly because of poor analytical sensitivity. 1).…”