Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations

Akimoto, Yoshiaki; Nishimura, Hitoshi; Komiya, Masamichi; Shibata, Toshimitsu; Kaneko, Kenji; Fujii, Akira; Tamura, Toyoyuki

doi:10.1016/0306-3623(85)90082-5

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…1985, Slots & Rams 1990), all strains of the present study were susceptible to ampicillin/sulbactam (MICs 0.19–2 µg/mL, MIC 90 0.75 µg/mL). In contrast, levels in saliva of both ampicillin and amoxicillin may not reach inhibitory concentrations (Smyth et al. 1981, Akimoto et al.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics

Müller

Holderrieth

Burkhardt

et al. 2002

J Clinic Periodontology

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Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics

Müller

Holderrieth

Burkhardt

et al. 2002

J Clinic Periodontology

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“…Akimoto et al . (21) examined the influence of ionization of cefadroxil (CDX) on excretion into saliva and reported that excretion into saliva of the positively charged CDX was suppressed. However, the antibiotics in the present study are water soluble and their distribution coefficients were all about 0.01 (data not shown).…”

Section: Discussionmentioning

confidence: 99%

The excretion of cephem antibiotics into saliva is inversely associated with their plasma protein‐binding activities

Hamada¹,

Ueta²,

Kodama

et al. 2002

J Oral Pathology Medicine

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“…Other substances which could not be detected in saliva are: gentamicin, tobramycin (81,82), cefsulodin, and inulin (82). The aminoglycoside antibiotics are extremely hydrophilic and, being polyamines, positively charged at physiological pH value.…”

Section: Ceftazidimmentioning

confidence: 99%

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1996

CCLM

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The determination of salivary drug concentrations is one of the major domains for the application of saliva in laboratory medicine. Its usefulness, however, has been criticized for many drugs because of the variability of the saliva/plasma concentration ratio (saliva/plasma ratio).Considering saliva as a model for transmembrane transport, drugs can be divided into 4 groups. The first group is characterized by a saliva/plasma ratio less than 1.0. In extreme cases a drug with negligible transport is either not detectable in saliva or is found in very low concentrations which are hard to measure or difficult to interpret.A second group leads to saliva/plasma ratios which are approximately constant and about 1.0 under most of the conditions studied. This group is ideal for monitoring salivary drug concentrations.A third group is sufficiently transferred into saliva, but the saliva/plasma ratio varies under different conditions. The reason for this variation is that the transport is influenced by several factors including an active transport mechanism. The varying influence of these factors on the saliva/plasma ratio largely depends on the physicochemical characteristics of the particular substance.In a fourth group very high saliva/plasma ratios are observed primarily due to the degree of ionization of weak bases.A representative of each group is presented with its saliva/plasma ratio and its physico-chemical properties: ceftazidim, ethanol, digoxin and prilocain. In all cases the salivary concentration probably reflects the intracellular concentration in target tissues. All examples confirm saliva as an ideal in vivo model for the study of transmembrane transport in the human organism.

show abstract

Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations

Cited by 11 publications

References 10 publications

In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics

In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics

The excretion of cephem antibiotics into saliva is inversely associated with their plasma protein‐binding activities

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