Concentrations of ampicillin in human serum and mixed saliva following a single oral administration of lenampicillin, and relationship between serum and mixed saliva concentrations.

Abstract

The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060 respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r =0.71, P <0.001, was found.

Detection of penicillin residues in bovine oral fluid (saliva) by liquid chromatography/tandem mass spectrometry

“…12 A correlation was observed between ampicillin concentration in serum and oral fluid, although the concentration was several hundred-fold lower in oral fluid (based on paper disc assay technique). 13 In contrast, oral doses of ciprofloxacin led to steady-state salivary concentration roughly half that of peak serum concentration. 14 Detection of cyclosporine in oral fluid was found to be a useful, non-invasive alternative for monitoring patients undergoing such therapy.…”