Relationship between seminal malondialdehyde levels and sperm quality in fertile and infertile men

Colagar, Abasalt Hosseinzadeh; Pouamir, M

doi:10.1590/s1516-89132009000600010

Cited by 43 publications

(22 citation statements)

References 30 publications

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“…Malondialdehyde (MDA) level of BAL fluid was assessed using the thiobarbituric acid method (TBAR) method (Colagar et al, 2009;Layali et al, 2015;Rao et al, 1989). Briefly, 5 ml of BAL fluids were centrifuged for 7 min at 2000g and then 100 l of supernatants was added in 900 l of distilled water into a glass tube.…”

Section: Mda Measurementmentioning

confidence: 99%

Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Marzony

Nejadmoghadam

Ghanei

et al. 2016

Environmental Toxicology and Pharmacology

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Section: Mda Measurementmentioning

confidence: 99%

Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Marzony

Nejadmoghadam

Ghanei

et al. 2016

Environmental Toxicology and Pharmacology

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“…ROS and RNS (e.g., H 2 O 2 , O 2 , and NO) are particularly reactive oxidizing factors, which are among free radicals reacting with macromolecules for compensation of their electron deficit (12). They can oxidize macro-molecules such as polyunsaturated fatty acids (PUFA), proteins, and carbohydrates (13).…”

Section: Introductionmentioning

confidence: 99%

“…Lipid peroxidation (LPO) is the main pathological effect of free radicals, correlated with PUFA oxidation in the sperm membranes (13). Malondialdehyde (MDA) is a steady byproduct of PUFA oxidation, which can be measured as a diagnostic index of sperm lipid peroxidation (13).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Oxidative Stress Intensity in the Seminal Plasma and Serum of Infertile Patients with Different Varicocele Grades and Subjects with No Varicocele: A Cross-Sectional Study

Yousefnia-Pasha

Mahjoub

Gholami

et al. 2017

Iran Red Crescent Med J

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“…Many previous studies improved that defective sperm function is associated with the presence of ROS in the seminal fluid, in which produced from many sources, and suggested that the ROS negatively correlated with sperm count, sperm motility and sperm morphology [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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Male infertility is an important medical and psychosocial problem worldwide. Therefore, it is important to identify new and non-conventional factors that may play significant role in male infertility. Current study focused on detecting more risk factors and markers for primary infertility in order to develop interventions for investigation and prevent their progressions. Oxidative stress has recently been identified as an underlying mechanism of numerous sources. The aim of the present study was therefore to evaluate whether there is an association between oxidative stress and male infertility in Erbil city subjects. The present prospective case control study was carried out between March to May 2013, in Maternity Teaching Hospital/in-vitro fertilization center and private clinical laboratory. 75 infertile males represent patients group were enrolled in this study. Apparently 40 healthy individuals who have no history of clinical evidence of any disease were also joined to this study as control group. Malondialdehyde (MDA), the marker of lipid peroxidation was measured in the seminal fluid of fertile and infertile male subjects. The sperm count, sperm morphology and motility, as well as semen volume were all found significantly lower in infertile subjects compared with fertile subjects (p<0.01). In seminal plasma, the MDA level was found significantly higher in infertile group (p<0.05). Lifestyle behaviours such as varicocele repair, cigarette smoking and alcohol consumption, all enhance the generation of ROS level in the seminal plasma, such elevation associated with decreased sperm quality particularly in term of sperm count and sperm motility that leading to increase male infertility.

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Relationship between seminal malondialdehyde levels and sperm quality in fertile and infertile men

Abstract: ABSTRACT

Cited by 43 publications

References 30 publications

Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Comparison of Oxidative Stress Intensity in the Seminal Plasma and Serum of Infertile Patients with Different Varicocele Grades and Subjects with No Varicocele: A Cross-Sectional Study

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

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