Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Marzony, Eisa Tahmasbpour; Nejadmoghadam, Amir; Ghanei, Mostafa; Panahi, Yunes

doi:10.1016/j.etap.2016.06.001

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…Eosinophils are a member of inflammatory response that are recruited to the damaged tissue and secret high levels of free radicals . Boskabady et al observed an increased number of eosinophils in lungs and BAL fluids of guinea pigs 14 days postexposure to SM. , Similarly, we have found overexpression of EPO in lungs of individuals who previously exposed to SM . However, the mechanism in which eosinophils are increased after SM exposure is unclear.…”

Section: Ros Producing-related Enzymessupporting

confidence: 64%

“…Peroxiredoxins (Prdx) are a new class of thiol-specific antioxidants that protect cells from the action of H 2 O 2 in their reduced form. 64 Prdx antioxidative activity is dependent on cellular GSH content. Sulfiredoxin-1, which is a crucial oxidoreductase enzyme, catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins using ATP and GSH.…”

Section: ■ Glutathione Depletionmentioning

confidence: 99%

“…65 Recent studies propose that the level of Prdx is increased in numerous pathological states accompanied by oxidative stress. 64,66 Tahmasbpour et al revealed overexpression of Prdx and Srx-1 mRNAs in lungs of SM exposed patients at chronic phase of injury, indicating the existence of oxidative stress in mustard lungs. 64 Since Srx1 catalyzes the reduction of oxidized Prxs using GSH, intracellular depletion of GSH may reduce the effectiveness of these enzymes in the lungs of SM-patients (Figure 3).…”

Section: ■ Glutathione Depletionmentioning

confidence: 99%

“…64,66 Tahmasbpour et al revealed overexpression of Prdx and Srx-1 mRNAs in lungs of SM exposed patients at chronic phase of injury, indicating the existence of oxidative stress in mustard lungs. 64 Since Srx1 catalyzes the reduction of oxidized Prxs using GSH, intracellular depletion of GSH may reduce the effectiveness of these enzymes in the lungs of SM-patients (Figure 3). Therefore, decreased intracellular GSH level induced by SM may affect activity of these antioxidant enzymes and cause to accumulation of ROS and oxidative damages to lung tissue.…”

Section: ■ Glutathione Depletionmentioning

confidence: 99%

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Free Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

Harchegani

Tahmasbpour

Borna

et al. 2018

Chem. Res. Toxicol.

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Sulfur mustard (SM) is a chemical alkylating compound that primary targets lung tissue. It causes a wide variety of pathological effects in respiratory system such as chronic bronchitis, bronchiolitis obliterans, necrosis of the mucosa and inflammation, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. However, molecular and cellular mechanisms for these pathologies are still unclear. Oxidative stress (OS) induced by reactive oxygen species (ROS) is likely a significant mechanism by which SM leads to cell death and tissues injury. SM can trigger various molecular and cellular pathways that are linked to ROS generation, OS, and inflammation. Hypoxia-induced oxidative stress, reduced activity of enzymatic antioxidants, depletion of intercellular glutathione (GSH), decreased productivity of GSH-dependent antioxidants, mitochondrial dysfunction, accumulation of leukocytes and proinflammatory cytokines, and increased expression of ROS producing-related enzymes and inflammatory mediators are the major events in which SM leads to massive production of ROS and OS in pulmonary system. Therefore, understanding of these molecules and signaling pathways gives us valuable information about toxicological effects of SM on injured tissues and the way for developing a suitable clinical treatment. In this review, we aim to discuss the possible mechanisms by which SM induces excessive production of ROS, OS, and antioxidants depletion in lung tissue of exposed patients.

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Section: Ros Producing-related Enzymessupporting

confidence: 64%

Section: ■ Glutathione Depletionmentioning

confidence: 99%

Section: ■ Glutathione Depletionmentioning

confidence: 99%

Section: ■ Glutathione Depletionmentioning

confidence: 99%

See 2 more Smart Citations

Free Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

Harchegani

Tahmasbpour

Borna

et al. 2018

Chem. Res. Toxicol.

Self Cite

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“…Expression analyses of genes involved in oxidative stress and antioxidant defense in biopsies from 6 lungs of SM-exposed subjects (after 25 years from the event) revealed a disrupted expression pattern for more than eighty genes. In particular, the most upregulated genes were peroxiredoxins (PRDXS) and sulfiredoxin-1 (SRXN1) [ 29 ], oxidative stress responsive kinase-1 (OXSR1), forkhead box M1 (FOXM1), glutathione peroxidase-2 (GPX2) [ 30 ], and reactive oxygen species (ROS); in association with aldehyde oxidase 1 (AOX1), myeloperoxidase (MPO), dual oxidase 1 and 2 (DUOX1, DUOX2), thyroid peroxidase (TPO), and eosinophil peroxidase (EPO) [ 31 ]. On the other hand, the most downregulated genes were metallothionein-3 (MT3) and glutathione reductase (GSR).…”

Section: Sulfur Mustardmentioning

confidence: 99%

Occupational Exposures and Environmental Health Hazards of Military Personnel

Geretto

Ferrari

Angelis

et al. 2021

IJERPH

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Background: Military personnels are frequently exposed to environmental pollutants that can cause a variety of diseases. Methods: This review analyzed publications regarding epidemiological and biomonitoring studies on occupationally-exposed military personnels. Results: The exposures include sulfur mustard, organ chlorines, combustion products, fuel vapors, and ionizing and exciting radiations. Important factors to be considered are the lengths and intensities of exposures, its proximity to the sources of environmental pollutants, as well as confounding factors (cigarette smoke, diet, photo-type, healthy warrior effect, etc.). Assessment of environmental and individual exposures to pollutants is crucial, although often omitted, because soldiers have often been evaluated based on reported health problems rather than on excessive exposure to pollutants. Biomarkers of exposures and effects are tools to explore relationships between exposures and diseases in military personnels. Another observation from this review is a major problem from the lack of suitable control groups. Conclusions: This review indicates that only studies which analyzed epidemiological and molecular biomarkers in both exposed and control groups would provide evidence-based conclusions on exposure and disease risk in military personnels.

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The c-Fos/AP-1 inhibitor inhibits sulfur mustard-induced chondrogenesis impairment in zebrafish larvae

Wang,

Ma,

Liu

et al. 2024

Chemosphere

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Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs

Cited by 17 publications

References 27 publications

Free Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

Free Radical Production and Oxidative Stress in Lung Tissue of Patients Exposed to Sulfur Mustard: An Overview of Cellular and Molecular Mechanisms

Occupational Exposures and Environmental Health Hazards of Military Personnel

The c-Fos/AP-1 inhibitor inhibits sulfur mustard-induced chondrogenesis impairment in zebrafish larvae

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