Relationship between SDB and short‐term outcome in Finnish ischemic stroke patients

Haula, Tuuli‐Maria; Puustinen, Juha; Takala, Mari; Holm, Anu

doi:10.1002/brb3.1762

Cited by 4 publications

(3 citation statements)

References 43 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We could not find other variables related to worse short-term functional outcome. In our previous study, higher disability and need of rehabilitation and longer hospitalization time were seen in OSA patients (Haula et al, 2020).…”

Section: Discussionmentioning

confidence: 74%

“…In our previous study, higher disability and need of rehabilitation and longer hospitalization time were seen in OSA patients. (Haula et al, 2020) Because the higher proportion of moderate-to-severe OSA in WUS patients we hypothesized we could find significant difference in the other two outcome measures. Reason for insignificant difference can be the low number of WUS patients with higher disability and even smaller number of those with combination of OSA and WUS in this group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Wake‐up strokes are linked to obstructive sleep apnea and worse early functional outcome

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background and Aims: Presence of sleep-disordered breathing (SDB) and especially obstructive sleep apnea (OSA) is a known risk factor for ischemic stroke. Additionally, SDB effects negatively on recovery after stroke. Up to one fourth of strokes are present on awakening. The link between OSA and wake-up stroke (WUS) has been suggested.We aim to determine the association between OSA and WUS in a Finnish stroke unit cohort. Material and Methods: An observational prospective longitudinal study consisted of 95 TIA (transient ischemic attack) and mild to moderate stroke patients referred to a Stroke Unit in Finland. Respiratory polygraphy was performed within 72 h of hospital admission. Patients were classified into WUS and non-WUS, and functional outcome measures (mRS, rehabilitation, hospitalization time) were collected. Functional outcomes and prevalence of OSA were compared between non-WUS and WUS.Results: OSA (AHI > 15/h) was more frequent among WUS than non-WUS (71% and 36%, respectively, p = 0.009). Functional outcome measured with mRS was worse in patients with WUS than non-WUS on registration day and at hospital discharge (p = 0.001). Need for rehabilitation in WUS was 43% of cases compared to 23% of non-WUS (p = 0.067). Hospitalization time was longer (5-15days) in 55% of WUS and 41% of non-WUS patients (p = 0.261). Conclusion:Moderate-to-severe OSA is related to WUS compared to non-WUS. In addition, WUS have worse short-term outcomes measured in mRS. Further studies are needed to determine if OSA is causally linked to WUS.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Wake‐up strokes are linked to obstructive sleep apnea and worse early functional outcome

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Consistent with our findings, a Finnish study reported positive associations between NIHSS scores at admission and discharge with SDB, mirroring the outcomes observed in our cohort. 17 In our study, minor strokes dominated the cohort, with a median NIHSS score of 2. [1][2][3][4] Good compliance with overnight PSG completion in minor stroke might explain this finding.…”

Section: Discussionmentioning

confidence: 63%

Nomogram for predicting moderate-to-severe sleep-disordered breathing in patients with acute ischaemic stroke: a retrospective cohort study

Gu,

Xie,

Liu

et al. 2024

BMJ Open

View full text Add to dashboard Cite

ObjectivesModerate-to-severe sleep-disordered breathing (SDB) is prevalent in patients with acute ischaemic stroke (AIS) and is associated with an increased risk of unfavourable prognosis. We aimed to develop and validate a reliable scoring system for the early screening of moderate-to-severe SDB in patients with AIS, with the objective of improving the management of those patients at risk.Study designWe developed and validated a nomogram model based on univariate and multivariate logistic analyses to identify moderate-to-severe SDB in AIS patients. Moderate-to-severe SDB was defined as an apnoea-hypopnoea index (AHI) ≥15. To evaluate the effectiveness of our nomogram, we conducted a comparison with the STOP-Bang questionnaire by analysing the area under the receiver operating characteristic curve.SettingLarge stroke centre in northern Shanghai serving over 4000 inpatients, 100 000 outpatients and emergency visits annually.ParticipantsWe consecutively enrolled 116 patients with AIS from the Shanghai Tenth People’s Hospital.ResultsFive variables were independently associated with moderate-to-severe SDB in AIS patients: National Institutes of Health Stroke Scale score (OR=1.20; 95% CI 0.98 to 1.47), neck circumference (OR=1.50; 95% CI 1.16 to 1.95), presence of wake-up stroke (OR=21.91; 95% CI 3.08 to 156.05), neuron-specific enolase level (OR=1.27; 95% CI 1.05 to 1.53) and presence of brainstem infarction (OR=4.21; 95% CI 1.23 to 14.40). We developed a nomogram model comprising these five variables. The C-index was 0.872, indicated an optimal agreement between the observed and predicted SDB patients.ConclusionsOur nomogram offers a practical approach for early detection of moderate-to-severe SDB in AIS patients. This tool enables individualised assessment and management, potentially leading to favourable outcomes.

show abstract