Relationship between Metabolic Syndrome and Uterine Leiomyomas: A Case-Control Study

Abstract

Background/Aims: Uterine leiomyomas are the most common gynecological benign tumor and greatly affect reproductive health and well-being. The pathophysiology and epidemiology of fibroids are poorly understood. Obesity and elevated blood pressure have been reported to be predisposing factors. In this study, we investigated whether fibroids are associated with some criteria of the metabolic syndrome. Methods: The case patients were 213 women who underwent hysterectomy or myomectomy for fibroids, and the control subjects were 159 women who underwent operation for benign indications other than fibroids. Preoperative information on body mass index (BMI), blood pressure (BP), serum triglyceride (TG) and fasting plasma glucose (FPG) was obtained from medical records. The patients were classified as overweight if they had a preoperatively measured BMI of ≧24.0, hypertensive if BP was ≧140/90 mm Hg, hypertriglyceridemic if TG was ≧150 mg/dl, and hyperglycemic if FPG was ≧110 mg/dl. Results: BMI, BP, TG and FPG were significantly higher in the case group compared with the control group. In logistic regression analysis, fibroids were statistically significantly associated with being overweight and hypertensive. With the combination of these risk factors, the risk of fibroids increased. Conclusion: Uterine leiomyomas may share pathogenic features with the development of metabolic syndrome.

Enhancing Uterine Fibroid Research Through Utilization of Biorepositories Linked to Electronic Medical Record Data

“…2,4,5,[14][15][16][17] Although high BMI has previously associated with fibroid risk, we did not observe a strong association with BMI, although there was evidence that increasing BMI is associated with increasing risk (overweight OR = 1.68; obese OR = 1.56). [18][19][20] However, the associations between BMI and fibroids have been inconsistent in prior published literature.…”

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

“…Although the relationship between reproductive factors and LMA is very complex and may be altered by factors such as parity or other anthropometric characteristics (Takeda, 2008) their interaction with AhR levels is not identified yet.…”

Premenapozal Kadınlarda Myoma Uteri Gelişimi Üzerine Visseral/Trunkal Yağ Oranının ve İnsülin Direncinin Etkisinin Değerlendirilmesi

“…1 The authors suggest that of BMI is not a main factor in obesity whereas increases of distribution of body fat, waist circumference and waisthip ratio may be associated with certain diseases including myoma uteri. 9 Unlike these studies, in the study of Takeda et al, 19 BMI was found significantly higher in the patient group and obesity was reported as a risk factor for myoma uteri formation. In this study, the waist circumference was ignored because although waist circumference is diagnostic on abdominal obesity, it is reported that, visceral fat rate could not be measured by waist circumference on patients with myoma uteri due to enlarged uterus volume.…”

“…In these studies, no significant correlation was found between fasting blood glucose level and myoma formation. 1,19 In one of these studies, the idea of "hyperglycemia may increase likelihood of myoma uteri formation" was inferred, because of fasting plasma glucose levels were found higher in the patient group. 1 No studies were found in literature which investigates the effect of HbA1c on myoma uteri formation.…”