Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Bidgoli, Sepideh Arbabi; Khorasani, Hoda; Keihan, Heideh; Sadeghipour, Alireza; Mehdizadeh, Abolfazl

doi:10.7314/apjcp.2012.13.11.5445

Cited by 23 publications

(19 citation statements)

References 22 publications

(16 reference statements)

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“…All information was collected by expert nurses who were blinded to the serological levels of calcium and Vitamin D. All variables were recorded and utilized according to standardized questionnaires/protocols that have been previously developed and successfully used by us (Bidgoli et al, 2012). Other than daily exposure to sunlight and all details regarding body coverage ,daily intake of calcium and vitamin D and all dietary resources of mentioned factors were collected.…”

Section: Questionnairesmentioning

confidence: 99%

Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Bidgoli

Azarshab²

2014

Asian Pacific Journal of Cancer Prevention

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Section: Questionnairesmentioning

confidence: 99%

Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Bidgoli

Azarshab²

2014

Asian Pacific Journal of Cancer Prevention

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“…7 A number of studies have evaluated exposure to environmental endocrine disruptors, such as diethylstilbestrol 8,9 (mixed), phenols 10 (null), dioxin 11 (protective), and polychlorinated biphenyls (increased), 12 but no clear patterns have emerged. A more recent study evaluated exposure to polycyclic aromatic hydrocarbons, another environmental estrogen-like compound, and odds of uterine leiomyomata expressing the aryl-hydrocarbon receptor 13 . Living closer to a polycyclic aromatic hydrocarbon producing company was associated with increased odds of uterine leiomyomata with aryl-hydrocarbon receptor over-expression.…”

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confidence: 99%

Air Pollution and Risk of Uterine Leiomyomata

et al. 2014

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Background Air pollution, particularly from vehicle exhaust, has been shown to influence hormonal activity. However, at present, it is unknown whether air pollution exposure is associated with the occurrence of uterine leiomyomata, a hormonally sensitive tumor of the uterus. Methods Proximity to major roadways and outdoor levels of PM less than 10 microns (PM10) or 2.5 microns (PM2.5) or between 10 and 2.5 microns (PM10–2.5) in diameter were determined for all residential addresses from September 1989 to May 2007 for 85,251 women aged 25–42 at enrollment in the Nurses’ Health Study II who were alive and responding to questionnaires, premenopausal with intact uteri, without diagnoses of cancer, or prevalent uterine leiomyomata. Incidence of ultrasound- or hysterectomy-confirmed uterine leiomyomata and covariates were reported on biennial questionnaires sent through May 2007. Multivariable time-varying Cox proportional hazard models were used to estimate the relation between distance to road or PM exposures and uterine leiomyomata risk. Results During 837,573 person-years of follow-up, there were 7,760 incident cases. Living close to a major road and exposures to PM10 or PM10–2.5 were not associated with an increased risk of uterine leiomyomata. However, each 10 µg/m3 increase in 2-year average, 4-year average, or cumulative average PM2.5 was associated with an adjusted hazard ratio (HR) of 1.08 (95% confidence interval (CI):1.00–1.17), 1.09 (95%CI:0.99–1.19) and 1.11 (95%CI:1.03–1.19), respectively. Conclusions Chronic exposure to PM2.5 may be associated with a modest increased risk of uterine leiomyomata.

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“…Over the last two decades, endocrine disruption has gained more public, political, and scientific attention. It is interesting to note that endocrine disruptors have been around in f hormone-dependent cancers for a long time (Cravedi et al, 2007;Bidgoli et al, 2012).…”

Section: Tumorigenic Effects Of Endocrine-disrupting Chemicals Are Almentioning

confidence: 99%

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Chu¹,

Cruz²,

Hwang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Cited by 23 publications

References 22 publications

Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Air Pollution and Risk of Uterine Leiomyomata

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

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