Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Bidgoli, Sepideh Arbabi; Azarshab, Hamid

doi:10.7314/apjcp.2014.15.8.3391

Cited by 36 publications

(41 citation statements)

References 20 publications

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“…Out of different lifestyle factors, increased body coverage against sunlight exposure (p=0.004, OR=2.868,95%CI 1.215-6.768) , lack of physical activity(p=0.043,OR=1.975,95%CI 0.97-4.03) and continuous(>5yrs) OCP consumption(p=0.003,OR= 3.1, 95%CI =1.32-7.29) were considered as three important risk factors of premenopausal breast cancer in this case and control study in Kermanshah like our previous studies in other provinces of Tehran (Bidgoli SA, 2011) (Bidgoli SA, 2014).…”

Section: Anthropometric and Background Factorssupporting

confidence: 64%

“…We have showed recently the role of vitamin D deficiency from dietary sources and lack of sun exposure on the incidence of premenopausal in Sabzevar of Iran (Bidgoli et al, 2014). Vitamin D is obtained from both dietary sources and exposure to sunlight (MF, 2007) and these two important ways were assessed at the same time in this study.…”

Section: Discussionmentioning

confidence: 99%

“…All information was collected by expert nurses according to standardized questionnaires/protocols that have been previously developed and successfully used by us (Bidgoli SA, 2014) .Other than demographic data, body measurements including weight, height, and calculated body mass index, occupation, physical activity (time spent in mild, moderate, and vigorous activities) , daily exposure to sunlight and all details regarding body coverage, daily intake of calcium and vitamin D and all dietary resources were collected. The dietary resources were categorized as below according to the KIDMED test (Castro-Quezada et al, 2014) Dietary fats: According to preliminary questions and local dietary habits dietary, fats were categorized to Kermanshahi animal oil, Solid animal oil, Plant derived oil, Butter /Margarin and Fish oil /omega 3.…”

Section: Questionnairesmentioning

confidence: 99%

“…Later the specific roles of PAHs, xenoestrogens, obesity (Bidgoli et al, 2011) and vitamin D deficiency (Bidgoli et al, 2014) on increased risk of premenopausal breast cancer was emphasized through dietary and environmental resources (Ataollahi et al, 2014) but there are still knowledge gaps regarding the roles of diet, adiposity and BMI in early life, at menarche and at lifetime period on increased risk of premenopausal breast cancer (Rosner et al, 2015) which may not support the hypothesis about the long term adult weight gain and increased risk of breast cancer like postmenopausal women (Suzuki et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Roles of Kermanshahi Oil, Animal Fat, Dietary and Non-Dietary Vitamin D and other Nutrients in Increased Risk of Premenopausal Breast Cancer: A Case Control Study in Kermanshah, Iran

Salarabadi

Bidgoli²,

Madani³

2015

Asian Pacific Journal of Cancer Prevention

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Section: Anthropometric and Background Factorssupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Questionnairesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Roles of Kermanshahi Oil, Animal Fat, Dietary and Non-Dietary Vitamin D and other Nutrients in Increased Risk of Premenopausal Breast Cancer: A Case Control Study in Kermanshah, Iran

Salarabadi

Bidgoli²,

Madani³

2015

Asian Pacific Journal of Cancer Prevention

Self Cite

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“…Differences in culture, habits and ethnicity in many countries of the Eastern Mediterranean Region (such as Iran, Tunisia and Pakistan) show that the BC diagnosis age is younger than the rest of the world (Bidgoli and Azarshab, 2013). Also, some countries in the Eastern Mediterranean Region, due to lack of knowledge about BC screening than other regions, are in more advanced stages of cancer at diagnosis time (Harirchi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Spatial Analysis of Breast Cancer Incidence in Iran

Mahdavifar¹,

Pakzad²,

Ghoncheh³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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of oncology death in women in these countries (Jemal et al., 2011). BC comprises about one-fifth of all female cancers. This cancer is the cause of deaths in high-income countries and the second cause of death in low and middle income countries (Payandeh et al., 2015b). BC is the most common cause of death in middle-aged women AbstractBreast cancer (BC) is the most common cancer in females (27% of the total) and the main cause of death (16%) due to cancer in women in developed and developing countries. Variations in its incidence rate among geographical areas are due to various contributing factors. Since there have been a lack of studies on this topic in our country, the present spatial analysis of breast cancer incidence in Iran in 2009 was conducted using data from the national cancer registry system. The reported incidences of the disease were standardized according to the World Health Organization population and the direct method. Then data was inserted into the GIS software and finally, using the Hot Spot Analysis (Geties-Ord Gi), high-risk areas were drawn. Provinces with incidences 1.96 SD higher or lower than the national average were considered as hot spots or cold spots, at the significance level of 0.05%. In 2009, a total of 7,582 cases of BC occurred in Iran. The annual incidence was 33.2 per hundred thousand people. Our study showed that the highest incidence of BC in women occurred in the central provinces of the country, Tehran, Isfahan, Yazd, Markazi and Fars. The results of hot spots analysis showed that the distribution of high-risk BC was focused in central parts of Iran, especially Isfahan province (p <0.01). The other provinces were not significantly different from the national average. The higher incidence in central provinces may be due to greater exposure to carcinogens in urban areas, a Western lifestyle and high prevalence of other risk factors. Further epidemiological studies about the etiology and early detection of BC are essential.

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The Level of Testosterone, Vitamin D, and Irregular Menstruation More Important than Omega-3 in Non-Symptomatic Women Will Define the Fate of Multiple Scleroses in Future

2016

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Multiple sclerosis is one of the most salient degenerative disorders of CNS with dysregulated immune process that resulted in axonal damage and demyelination. In the present investigation, the serum level of testosterone was assessed in women who were struggling with multiple sclerosis (MS). Also, the level of omega-3, vitamin D, and the irregular menstruation in women 5 years before the onset MS symptoms were surveyed. Although the levels of omega-3 and vitamin D in women MS patients were non-significant and significantly less than the healthy ones, they were significantly less in the whole population of MS patients. However, the MS patients more experienced more irregular menstruation some years before the onset of MS with the low level of testosterone. Based on the presented findings, it might be said that the vitamin D intake has significant protective role in women and men MS patients unlike the omega-3 that had significant protective role just in men. However, vitamin D metabolism encoding genes of CYP27B1 and CYP24A1 and predicting MS risk gene of HLA-DRB1*15:01 define its fate as well. Besides, vitamin D intake, through the proliferation decrement of pro-inflammatory cells, decreases of pro-inflammatory markers (IL-6, TNF-α, INF-γ) and auto-immune pathways have potential role in recovery of irregular menstruation in women with the low level of testosterone as a red warning factor of MS development. The low level of testosterone and vitamin D consumption increase the neural damage and pro-inflammatory pathways in MS patients, and the difference among the investigations is related to the long-standing history of MS that influences severity of damage to the neural cells and biomolecules and complicate its recovery.

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Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Cited by 36 publications

References 20 publications

Roles of Kermanshahi Oil, Animal Fat, Dietary and Non-Dietary Vitamin D and other Nutrients in Increased Risk of Premenopausal Breast Cancer: A Case Control Study in Kermanshah, Iran

Roles of Kermanshahi Oil, Animal Fat, Dietary and Non-Dietary Vitamin D and other Nutrients in Increased Risk of Premenopausal Breast Cancer: A Case Control Study in Kermanshah, Iran

Spatial Analysis of Breast Cancer Incidence in Iran

The Level of Testosterone, Vitamin D, and Irregular Menstruation More Important than Omega-3 in Non-Symptomatic Women Will Define the Fate of Multiple Scleroses in Future

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