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Ischemia-reperfusion injury in rat kidneys most probably comes from oxidative stress, but the possible preventive effect of alpha-tocopherol (AT) treatment on this injury has not yet been established. Forty male Wistar rats were randomly divided into four groups. The left renal arteries of all rats except the controls were clamped to induce renal ischemia. The left kidneys of the rats in the ischemia group were removed following 40 min ischemia. The rats in the ischemia-reperfusion and ischemia-reperfusion-AT groups were treated similarly, but in these groups the renal arteries were re-perfused for 1 h following ischemia. The rats in the ischemia-reperfusion-AT group also received 10 mg/kg AT 3 h prior to ischemia. The specimens were examined histopathologically and ultrastructurally, and the tissue calcium levels were measured. Light microscope and ultrastructural examination showed that the greatest damage occurred in the ischemia-reperfusion group. The highest level of tissue calcium was also found in this group. In the ischemia-reperfusion-AT-treated group, less tissue damage and a lower tissue calcium concentration was found compared to both the ischemia and ischemia-reperfusion groups. Our results indicate that AT can reduce tissue damage after ischemia-reperfusion injury.

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ÖzAmaç: Antenatal bakım ve tarama testlerinin anne ve bebeğin mortalitesini azalttığı bilinmektedir. Çalışmamızda antenatal tarama testlerini yaptırmak konusunda hastaları en çok etkileyen faktörleri tespit etmeyi amaçladık. Medyanın gebe kadınların antenatal tarama testlerine yaklaşımına etkilerini değerlendirmeyi planladık. Materyal ve Metot: Gebe polikliniğine 30 günlük süre içinde başvuran 310 gebenin gebelikteki tarama testlerine yaklaşımları çeşitli sorularla değerlendirilmiştir. Bulgular: Gebelerin kadın hastalıkları ve doğum uzmanının yanı sıra aile hekimlerine rutin takip olmaları bilgilenme düzeylerine olumlu katkıda bulunmaktadır. Özellikle diyabet tarama testini yaptırmak istemeyen gebelerin çoğunlukla medyatik açıklamalardan etkilendiği tespit edilmiştir. Sonuç: Antenatal tarama testleri ile ilgili bilgilendirme yapma konusunda gebeyi ilk muayene eden hekime büyük görev düşmektedir. Hastaların testlere yaklaşımını olumsuz etkileyen faktörlerden en sık olanı olan medyatik açıklamaların kontrollü yapılabilmesi için de gerekli düzenlemeler yapılmalıdır. Anahtar kelimeler: Antenatal tarama testleri, gebelikte diyabet tarama testi, medya etkisi Abstract Objectives: Prenatal screening tests reduce the maternal and perinatal mortality as known. In our study, we aimed to investigate which factors affect the pregnant women most on how to take antenatal screening tests. We planned to evaluate the effects of media on pregnant women's approach to antenatal screening tests. Materials and methods: 310 pregnant women who were admitted to the pregnancy outpatient clinic within 30 days have been evaluated by a variety of questions. Results: Follow ups of pregnant women by their gynecologists and family doctors increase the level of knowledge for screening tests. Particularly the pregnant women who do not want to take the diabetes screening test have been mostly affected by the media. Conclusion: Clinicians who examine to pregnant women firstly have a great duty to inform about them antenatal screening tests. We need to make arrangements on mediatic explanations that affect the pregnant women negatively about screening tests.

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