Relationship between lipid and hematological profiles with adiposity in obese adolescents

Abstract

BackgroundAn excess of weight including obesity have reached epidemic rates in all age groups, both in developed and developing countries. It is notable that overweight children and adolescents have a higher likelihood of becoming obese adults and to present health-related problems early in life.ObjetivesTo verify associations of the lipid and hematological profiles with adiposity in obese adolescents beginning multidisciplinary weight loss therapy.MethodsThis cross-sectional study was conducted with 85 adolescents of both genders, aged 12-19 years (Tanner staging 3 or 4) and body mass index greater than the 95th percentile. The sum of the triceps, subscapular and calf skinfolds and the waist circumference were used to estimate adiposity. Blood samples were collected from all patients after overnight fasting to analyze blood lipids (total cholesterol, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein and triglycerides), blood sugar and the hematological profile (hemoglobin, platelets and red blood cells). The Kolmogorov-Smirnov test and Spearman and Pearson correlation coefficients were used for statistical analysis with significance set for p-values ≤ 0.05.ResultsThere were statistical differences between genders for red blood cells (p-value = 0.000), hemoglobin (p-value = 0.000) and platelets (p-value = 0.002). Positive correlations were found for red blood cells (p-value = 0.031) and hemoglobin (p-value = 0.024) with waist circumference. There was a negative correlation between hemoglobin and the sum of skinfolds (p-value = 0.022).ConclusionThe results demonstrate an association between the lipid and hematological profiles and body adiposity in obese adolescents thus reinforcing the importance of treating obese adolescents early to prevent health related problems in adult life.

Relação Entre Indicadores Antropométricos E Hematológicos De Pais E Seus Filhos

“…Um estudo relatou que mulheres adultas tinham maior risco de síndrome metabólica, quanto maiores seus níveis de hemoglobina, hematócrito, plaquetas e leucócitos, embora hemoglobina e hematócrito, parâmetros aqui avaliados, não tenham se associado por si só com os parâmetros antropométricos avaliados por eles 17 . Entre os filhos, a CC associou-se com hemoglobina e com hematócrito em nossa pesquisa, assim como relata também um estudo com adolescentes pernambucanos, que encontrou associação entre hemácias e hemoglobina com CC 18 . Diferentemente, autores que avaliaram escolares mexicanos não encontraram associação entre hemoglobina e IMC 19 .…”

Perbedaan profil lipid pada remaja obes dan tidak obes di Kecamatan Bolangitang Barat

“…17 Dari hasil analisis perbedaan antara kadar trigliserida pada remaja obes dan remaja tidak obes didapat nilai p >0,05, yang menunjukkan tidak terdapat perbedaan kadar trigliserida antara remaja obes dan tidak obes; juga tidak didapatkan hubungan antara kadar trigliserida dan IMT. Hasil ini berbeda dengan yang didapatkan oleh Valverde et al 19 tetapi sejalan dengan yang dilaporkan oleh Ferreira et al 20 di Brasil yang tidak menemukan adanya hubungan trigliserida dengan remaja obes.…”

“…17 Pada hasil uji analisis antara kadar LDL pada remaja obes dan remaja tidak obes didapat nilai p<0,05 yang berarti terdapat perbedaan kadar LDL pada remaja obes dan tidak obes serta adanya hubungan antara kadar LDL dan IMT pada remaja. Hasil yang sama juga diperoleh oleh Zamani et al 21 yang menemukan adanya hubungan antara LDL dengan IMT, yang berbeda dengan hasil yang ditemukan oleh Ferreira et al 20 Berdasarkan hasil penelitian diperoleh 16 remaja obes (55%) dan 16 remaja tidak obes (51%) memiliki kadar HDL yang abnormal. Hasil yang ditemukan oleh Togelang et al 22 pada remaja obes di Kabupaten Minahasa yaitu 100% memiliki kadar HDL abnormal, sedangkan yang diperoleh oleh Senduk et al 11 pada remaja obes di Kota Bitung dengan kadar HDL abnormal ialah 62%.…”

Comment on: Relationship between lipid and hematological profiles and adiposity in obese adolescents

“…The study entitled "Relationship between lipid and hematological profiles and adiposity in obese adolescents" featured in this issue of the Revista Brasileira de Hematologia e Hemoterapia, measured waist circumference, body mass index (BMI), sum of skinfolds, red blood cell and platelet counts, hemoglobin level and serum levels of total cholesterol, triglycerides and HDL, with the objective of verifying associations between lipid and hematological profiles with the adiposity body index of obese adolescents admitted in a multidisciplinary treatment ( 9 ) .…”

“…Thus, the study of Ferreira et al is highly relevant since it serves as a reference to the different health professionals by presenting important data on a context that is still rarely addressed in the literature, allowing interpretations and referrals in order to avoid or reduce exposure to cardiovascular risks and to the healt of obese adolescents ( 9 ) .…”