Comment on: Relationship between lipid and hematological profiles and adiposity in obese adolescents

Guerra, Ricardo Luís Fernandes

doi:10.5581/1516-8484.20130047

Cited by 1 publication

(1 citation statement)

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“… 2 In Brazil, SCD is unevenly distributed among the population, as it is more prevalent in the Brazilian states with the greatest numbers of individuals who are descendants of slaves. 3 …”

Section: Introductionmentioning

confidence: 99%

Relationship between pulmonary and cardiac abnormalities in sickle cell disease: implications for the management of patients

Maioli

Soares

Bedirian

et al. 2016

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveTo evaluate the association between clinical, pulmonary, and cardiovascular findings in patients with sickle cell disease and, secondarily, to compare these findings between sickle cell anemia patients and those with other sickle cell diseases.MethodsFifty-nine adults were included in this cross-sectional study; 47 had sickle cell anemia, and 12 had other sickle cell diseases. All patients underwent pulmonary function tests, chest computed tomography, and echocardiography.ResultsAbnormalities on computed tomography, echocardiography, and pulmonary function tests were observed in 93.5%, 75.0%; and 70.2% of patients, respectively. A higher frequency of restrictive abnormalities was observed in patients with a history of acute chest syndrome (85% vs. 21.6%; p-value < 0.0001) and among patients with increased left ventricle size (48.2% vs. 22.2%; p-value = 0.036), and a higher frequency of reduced respiratory muscle strength was observed in patients with a ground-glass pattern (33.3% vs. 4.3%; p-value = 0.016). Moreover, a higher frequency of mosaic attenuation was observed in patients with elevated tricuspid regurgitation velocity (61.1% vs. 24%; p-value = 0.014). Compared to patients with other sickle cell diseases, sickle cell anemia patients had suffered increased frequencies of acute pain episodes, and acute chest syndrome, and exhibited mosaic attenuation on computed tomography, and abnormalities on echocardiography.ConclusionA significant interrelation between abnormalities of the pulmonary and cardiovascular systems was observed in sickle cell disease patients. Furthermore, the severity of the cardiopulmonary parameters among patients with sickle cell anemia was greater than that of patients with other sickle cell diseases.

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“… 2 In Brazil, SCD is unevenly distributed among the population, as it is more prevalent in the Brazilian states with the greatest numbers of individuals who are descendants of slaves. 3 …”

Section: Introductionmentioning

confidence: 99%