Obesity might cause dyslipidemia, marked by increased cholesterol, triglycerides, and LDL levels, as well as reduced HDL level. Dyslipidemia is related to atherosclerosis that can result in cardiovascular diseases. This study was aimed to identify differences of lipid profiles in obese and non-obese teenagers at West Bolangitang, North Bolaang Mongondow. This was an observational analytical study with a cross sectional design conducted from October to November 2016. Subjects were 60 teenagers obtained by using consecutive sampling method and were divided into two groups: obese (29 teenagers) and non-obese (31 teenagers). Lipid profile examinations were performed on all of them. Statistical analysis of total cholesterol level of the two groups used independent t test (p=0.002) dan Pearson correlation test (p=0.028). The normality test of triglyseride level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.328) and Spearman correlation test (p=0.542). The normality test of LDL level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.004) and Spearman correlation test (p=0.032). The normality test of HDL level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.063) and Spearman correlation test (p=0.054). Conclusion: There were significant differences of total cholesterol and LDL levels but there were no significant differences of triglyceride and HDL levels between obese teenagers and non-obese teenagers.Keywords: lipid profile, adolescents, obesity. Abstrak: Obesitas dapat menyebabkan peningkatan lipid kolesterol, trigliserida, maupun LDL dan penurunan lipid HDL yang disebut dislipidemia. Dislipidemia berhubungan erat dengan terjadinya aterosklerosis yang dapat menimbulkan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui perbedaan profil lipid pada remaja obes dan remaja tidak obes di Kecamatan Bolangitang Barat, Kabupaten Bolaang Mongondow Utara. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Penelitian dilaksanakan pada bulan Oktober dan November 2016 dengan sampel penelitian berjumlah 60 remaja terdiri dari kelompok remaja obes (29 orang) dan kelompok remaja tidak obes (31 orang) yang diperoleh dengan metode consecutive sampling. Pemeriksaan profil lipid dilakukan pada semua remaja. Uji statistik terhadap kadar kolesterol total antara kedua kelompok menggunakan uji independent t test (p=0,002) dan uji Pearson correlation (p=0,028). Uji normalitas terhadap kadar trigliserida mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,328) dan uji korelasi Spearman (p=0,542). Uji normalitas terhadap kadar LDL mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,004) dan uji korelasi Spearman (p=0,032). Uji normalitas terhadap kadar HDL mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,063) dan uji korelasi Spearman (p=0,054). Simpulan: Terdapat perbedaan bermakna dalam hal kadar kolesterol total dan LDL, tetapi tidak terdapat perbedaan bermakna dalam hal kadar trigliserida dan HDL antara remaja obes dan tidak obes. Kata kunci: profil lipid, remaja, obesitas
Amalgam is a popular dental filling due to its cheaper price than other dental fillings. Basically, amalgam is an alloy, consists of two or more metals; one of them is mercury. The unfavorable thing about this alloy is that its vapor in the oral cavity can trigger the development of mercury-resistant bacteria. This type of bacteria has an enzyme called mercury reductase that can reduce Hg2+ to Hg0. 16SsRNA is a gene that contains important information to describe the prokaryotic type. This study was aimed to identify the type of mercury-resistant bacteria from dental plaque of patients with amalgam fillings. Samples were taken from the dental plaques. Isolation of DNA, sequensing of 16SsRNA gene by using PCR, and online BLAST through GenBank NCBI, and finally looking for the closest relative using a phylogenetic tree were performed in the Pharmacy Laboratory, Faculty of Mathematics and Science. The result of BLAST showed 4 types of bacteria, and the closest relative is B. thuringiensis. Conclusion: The type of mercury-resistant bacteria found in dental plaques was Bacillus thuringiensis.Keyword: amalgam, mercury resistant bacteria, dental plaques, 16SsRNA, PCR Abstrak: Amalgam adalah suatu logam campuran yang terdiri dari dua atau beberapa logam yang salah satunya adalah merkuri atau air raksa. Amalgam sebagai bahan tumpatan sampai saat ini masih banyak digunakan oleh dokter gigi karena harganya yang relatif murah. Namun penggunaan amalgam ini dapat melepaskan uap merkuri selama berada di dalam rongga mulut. Penggunaan amalgam ini memicu munculnya bakteri yang resisten terhadap merkuri dimana bakteri dapat mereduksi Hg2+ menjadi Hg0 melalui enzim yang menginduksi merkuri reduktase. 16SsRNA adalah gen yang menampung informasi-informasi penting agar mendeskripsikan jenis-jenis prokariotik. Penelitian ini bertujuan untuk mengidentifikasi bakteri resisten merkuri pada plak gigi pasien pengguna tumpatan amalgam menggunakan metode PCR. Jenis penelitian ialah deskriptif observatif. Sampel diambil dari plak gigi pasien pengguna tumpatan amalgam di Laboratorium Farmasi Fakultas MIPA. Dilakukan langkah-langkah untuk isolasi DNA, sekuensing gen 16SsRNA menggunakan PCR, kemudian dilakukan BLAST secara online melalui GenBank NCBI lalu dicari kekerabatannya menggunakan pohon filogenetik. Hasil BLAST mendapatkan 4 jenis bakteri, dan kekerabatan terdekatnya ialah Bacillus thuringiensis. Simpulan: Jenis bakteri resisten terhadap merkuri pada plak gigi ialah Bacillus thuringiensis.Kata kunci: amalgam, bakteri resisten merkuri, plak gigi, 16SsRNA, PCR
Hyperuricemia is one state that is now likely to be obtained at adolescent. The state of hyperuricemia can be influenced by many factor, for example is the nutritional status. This study aims to determine the correlation between uric acid levels and nutritional status in adolescents in the District of West Bolangitang. This study is cross-sectional analytic. The subjects were adolescents from middle and high school in the District of West Bolangitang. Respondents were entering the study were 60 children, 16 boys and 44 girls. From the results obtained hyperuricaemia 16 children, and 12 (75%) were obese, 1 underweight, normal 2 and 1 overweight. Conclusion: There is a correlation between uric acid levels and nutritional status in adolescents in the District of West BolangitangKeywords: hyperurisemia, uric acid, nutritional status Abstrak: Hiperurisemia merupakan salah satu keadaan yang sekarang cenderung didapatkan pada usia yang lebih muda. Keadaan hiperurisemia ini dapat dipengaruhi oleh berbagai hal, salah satu contohnya adalah status gizi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat. Penelitian ini bersifat cross-sectional analitik. Subjek penelitian ini adalah remaja dari SMP dan SMA di Kecamatan Bolangitang Barat. Responden yang mengikuti penelitian berjumlah 60 anak, 16 laki-laki dan 44 perempuan. Dari hasil pemeriksaan didapatkan 16 anak hiperurisemia, dan 12 (75%) diantaranya obesitas, 1 underweight, 2 normal dan 1 overweight. Simpulan: Terdapat hubungan antara kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat Kata kunci: hiperurisemia, kadar asam urat, status gizi
Mercury as one of the dangerous contaminants, are neurotoxins and enter into aquatic ecosystems through atmospheric deposition or derived from industrial waste externalization. Methods: This research using descriptive and exploratory method. After getting the sample (feces, urine, tartar), the study followed by laboratory tests. Result: It was found that bacterias resistant to HgCl2: streptococcus sp, E. coli, and clostridium sp, while the bacterias that resistant to phenyl mercury: bacillus sp and sp aeroccus. Keywords: Bacteria Resistance, HgCl2, Phenyl Mercury, Feces, Urine, Tartar, Coastal Marine. Abstrak: Merkuri sebagai salah satu zat pencemar yang berbahaya, bersifat neurotoksin dan masuk ke dalam ekosistem akuatik melalui deposisi atmosferik, maupun berasal dari eksternalisasi limbah industry. Metode: Penelitian ini bersifat deskriptif dan bersifat eksploratif. Kemudian setelah mendapatkan sampel (feses, urin, karang gigi), penelitian dilanjutkan dengan pemeriksaan lab. Hasil: Didapatkan bakteri yang resisten terhadap HgCl2 : streptococcus sp, E.Coli, dan clostridium sp. Sedangkan bakteri yang resisten terhadap fenil merkuri: bacillus sp dan aeroccus sp. Kata kunci: Bakteri Resistensi, HgCL2, Fenil Merkuri, Feses, Urin, Karang Gigi, Daerah Pesisir Pantai.
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