Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis

Alami, Houda El; Ghazal, Hassan; Abidi, Omar; Idrissi, Najib Al; Wakrim, Lahcen; Naamane, Abderrahim; Khlil, Naima; Hamdi, Salsabil

doi:10.1016/j.dsx.2021.102386

Cited by 2 publications

(2 citation statements)

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“…Ethnicity and gender may explain, at last partially, previous conflicting results regarding the impact of ACE I/D in predisposition for T2DM ( 26 ). The ACE DD genotype was found to increased risk of hypertension and/or diabetes in Egyptian ( 27 ), Malaysian ( 28 ), Chinese ( 29 ) populations, but not in Turkish ( 30 ) or Emirati ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…The ACE DD genotype was found to increased risk of hypertension and/or diabetes in Egyptian ( 27 ), Malaysian ( 28 ), Chinese ( 29 ) populations, but not in Turkish ( 30 ) or Emirati ( 31 ). Meta-analyses have also described a positive association with subjects from Middle East, North Africa ( 26 ) or Asia ( 32 ), whereas, among Europeans, the results are more heterogenous ( 33 , 34 ). The number of ACE D variants was correlated with an increase in ACE activity ( 35 ) and angiotensin II signal transduction influences secretion of oxytocin ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

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The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome

Zenoaga-Barbăroșie,

Berca,

Vassu-Dimov

et al. 2023

Balkan Journal of Medical Genetics

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Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to investigate the association between six common genetic polymorphisms and T2DM and MetS in males. A total of 120 T2DM, 75 MetS, and 120 healthy controls (HC) were included in the study. ACE ID, eNOS 4a/b, ATR1 A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene polymorphisms were genotyped by PCR or PCR-RFLP techniques. T2DM was diagnosed at an earlier age compared to MetS (54 vs 55 years old, p=0.0003) and the difference was greater in carriers of the OXTR G allele (54 vs 56 years old, p=0.0002) or both OXTR G and eNOS b alleles (54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11, p=0.0006) and the presence of both ACE I and OXTR1 A (O.R.=0.39, p=0.0005) alleles revealed to be protective for T2DM. SOD1 AA and AC genotypes were protective factors for triglyceride (p=0.0002 and p=0.0005, respectively) and HDL cholesterol (p=0.0002 and p=0.0004, respectively) levels in T2DM patients. ACE DD was identified more frequently in hypertensive T2DM patients (O.R.=3.77, p=0.0005) and in those who reported drinking alcohol (p=0.0001) comparing to HC and T2DM patients who did not drink alcohol, respectively. We observed that T2DM patients who reported drinking alcohol had an increased frequency of ACE DD and eNOS bb (p<0.0001), or ACE DD and OXTR G (p<0.0001) compared to non-drinkers. No gene polymorphisms were associated with MetS.

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