Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese

Zhai, Zhensheng; Wang, Z.; Wang, L.; Chen, S.; Ren, Huizhu; Wang, D.

doi:10.1007/s00059-017-4591-0

Cited by 8 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of particular interest in the context of this review are works in which the NOS1, NOS2, and NOS3 genes SNVs were considered as risk factors for several comorbid disorders, including AH and M or associated conditions. + [23] rs2779249 - [11,12] +* [11] + [26,27] - [25] +* [25,26] rs2297518 - [11,12] +* [11,12] + [25,27] - [26] +* [25,26] NOS3 rs148554851 - [18] -* [18] rs1799983 + [13,17,20] - [8,10,12,14,15,18] -* [14,15,18] + [30,34] ± [24] - [28,29,[31][32][33]35] +* [30,32]-* [31] rs1800779…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

et al. 2021

View full text Add to dashboard Cite

Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Specifically, the OR was 1.27 (95% CI 1.12-1.44) in the additive model, 1.31 (1.09-1.59) in the dominant model, and 1.68 (1. 28-2.19) in the recessive model rs2779249; and 1.26 (1.06-1.50) in the additive model and 1.46 (1.13-1.89) in the dominant model rs2297518 [27].…”

Section: Gene Nos2mentioning

confidence: 99%

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

et al. 2021

View full text Add to dashboard Cite

show abstract

“…iNOS variant rs2779249 (-1026 C>A) is also located in the promoter region of the gene and it has been shown that nucleotide change from C to A increases iNOS promoter transcriptional activity to five-fold leading to higher NO production [22]. This SNP has been associated with hypertension in Chinese Han population and with rheumatoid arthritis in Indians [23,24]. For the -954G>C polymorphism, the substitution of G to C results in a phenotype with a seven-fold higher baseline NOS activity [25].…”

Section: Discussionmentioning

confidence: 99%

Association of Polymorphisms in the Promoter Region of NOS2A Gene with Primary Knee Osteoarthritis in the Greek Population

Leonidou

Lepetsos

Kenanidis

et al. 2020

Cureus

View full text Add to dashboard Cite

IntroductionA new emerging role of nitric oxide (NO) in the aetiology of osteoarthritis (OA) has been reported. Inducible NO synthase (iNOS), produced by chondrocytes, is the major source of NO in the osteoarthritic cartilage. The aim of this study is to evaluate the potential association between the -1173C/T (rs9282799), -1026 C/A (rs 2779249) and -954G/C (rs1800482) single nucleotide polymorphisms (SNPs) in the promoter of the iNOS gene (NOS2A) and the incidence of knee OA in Greek population. MethodsNinety-six patients with primary knee OA were included in the study along with 44 controls. Genotypes were identified using polymerase chain reaction (PCR) and DNA sequencing techniques. Allelic and genotypic frequencies were compared between patients and controls.

show abstract

Ankylosing spondylitis risk factors: a systematic literature review

2021

View full text Add to dashboard Cite

Relationship between inducible NOS single-nucleotide polymorphisms and hypertension in Han Chinese

Abstract: The current study provides evidence that iNOS is strongly associated with hypertension.

Cited by 8 publications

References 24 publications

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

Association of Polymorphisms in the Promoter Region of NOS2A Gene with Primary Knee Osteoarthritis in the Greek Population

Ankylosing spondylitis risk factors: a systematic literature review

Contact Info

Product

Resources

About