Relationship between <i>Campylobacter rectus</i> and periodontal status during pregnancy

Yokoyama, Masaaki; Hinode, Daisuke; Yoshioka, Masami; Fukui, Makoto; Tanabe, Shingo; Grenier, Daniel; Itô, Haruo

doi:10.1111/j.1399-302x.2007.00391.x

Cited by 56 publications

(62 citation statements)

References 35 publications

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“…[1][2][3] Higher levels of Campylobacter rectus and Prevotella nigrescens have also been found among these women. 4,5 However, this issue remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women

et al. 2012

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The aim of this study was to use the fluorescence in situ hybridization (FISH) technique to test the hypothesis of qualitative and quantitative differences of 8 periodontopathogens between pregnant and non-pregnant women. This cross-sectional study included 20 pregnant women in their second trimester of pregnancy and 20 non-pregnant women. Probing depth, bleeding on probing, clinical attachment level, and presence of calculus were recorded. Subgingival plaque samples were collected and the FISH technique identified the presence and numbers of Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Campylobacter rectus, Porphyromonas gingivalis, Treponema denticola, Fusobacterium nucleatum, Prevotella intermedia and Prevotella nigrescens. The Mann-Whitney U-test was applied to compare the data between the two groups. The mean age, ethnicity, marital status, education, and economic level in both groups were similar. The clinical parameters showed no significant differences between pregnant and non-pregnant women. The numbers of subgingival periodontopathogens were not found to be significantly different between groups, despite the higher mean counts of P. intermedia in pregnant women. Colonization patterns of the different bacteria most commonly associated with periodontal disease were not different in the subgingival plaque of pregnant and non-pregnant women.

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“…[1][2][3] Higher levels of Campylobacter rectus and Prevotella nigrescens have also been found among these women. 4,5 However, this issue remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women

et al. 2012

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“…Female sex hormones may directly promote microbial growth, as they stimulate P. intermedia growth [26,27] and an increase in both P. intermedia and P. gingivalis in response to hormonal changes during pregnancy [17,19] has been reported. However, due to variable and sometimes conflicting reports in the literature, there is no strong consensus linking increased concentrations of female sex hormones and an increased number (microbial load) of specific periodontal pathogens.…”

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium considered to be an important pathogen of periodontal disease that is also implicated in adverse pregnancy outcome (APO). Until recently, our understanding of the role of P. gingivalis in APO has been limited and sometimes contradictory. The purpose of this review is to provide an overview of past and current research on P. gingivalis that addresses some of the controversies concerning the role of this organism in the pathogenesis of APO.ARTICLE HISTORY

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“…Stimulation of RANKL B-lymphocyte synthesis and activation of osteoclasts [50] T. forthisia o-glycans: Inhibition of t1 response [24] LPS: Induction of il-6 synthesis, tnfb by gingival fibroblasts BspA: Induction of the th2 response associated with bone resorption [25] 1. Proteases: Degradation of the intercellular matrix [40] P. intermedia LPS: Induction of the synthesis of pro-inflammatory cytokines by gingival epitheliocytes and periodontal ligament cells [30] 1. Enhanced expression of metalloproteinases mmp-2 and mmp-9 with osteoblasts [41] P the MFA and the neck of viruses: The HSV, the EBV, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Induction of osteoclastogenesis due to cleavage of osteoprotegerin [30,49] C. rectus LPS: Stimulation of synthesis by gingival prostaglandin fibroblasts е2, il-1 and il-6 [32] Groel: Induces secretion by gingival cells il-6 and il-8 [38,45] T. denticola Chymotrypsin-like protease: Lysis of the components of the intercellular matrix (hyaluronic acid, chondroitin sulfate, fibronectin, laminin, fibrinogen) [16,17] A. actinomycetocomitans 1. Activation TLR-4 and myd88: Stimulation of differentiation of blood monocytes into osteoclasts [22] 2.…”

Section: Discussionmentioning

confidence: 99%

“…[28][29][30] The components of C. rectus induce the synthesis of proinflammatory mediators: Thus, LPS of a cell wall stimulates the synthesis of prostaglandin E2 gingival fibroblasts, the pro-inflammatory cytokines IL-1c and IL-6, and the rectum culture supernatant C. rectus induces the synthesis of IL-1b, IL-6, and IL-8 in the culture of human macrophages. [31] In addition, GroEL, a heat shock protein that is part of C. rectus, induces secretion by IL-6 gingival fibroblasts.…”

Section: P Intermediamentioning

confidence: 99%

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Batyrbekova¹

2017

AJP

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Pyoinflammatory diseases of maxillofacial area (MFA) are one of the most serious problems of maxillofacial surgery. The high medical and social significance of these diseases are due to their frequent occurrence in persons of working age and the risk of life-threatening complications: Bleeding from the great vessel, brain abscess, the spread of infection into the deep cellular spatium of the collum. In more than 1/3 of all patients, pyogenic lesions of MFA develop on the background of secondary immunodeficiency, accompanied by impaired regulation of the secretion of pro-inflammatory cytokines, and predisposing to prolonged smoldering flow or, on the contrary, rapid spread of inflammation with extensive tissue damage. This fact determines the importance of developing integrated approaches to diagnostics and treatment. The aim of the study is to generalize modern ideas about causative agents and their effect on the features of the inflammatory diseases of the MFA. We systematized and analyzed contemporary works of Russian and foreign authors on the study of the effects of causative agents of bacterial and viral nature and characteristic changes in the immune status. The modern data on the role of microbial factors in the development and maintenance of local and systemic immunological status disorders in case of inflammatory disease of MFA are presented, the impact on the development of bacterial and viral microflora diseases is given, with special attention paid to immunomodulatory effects of causative agents. The factors of pathogens influence most frequently associated with inflammatory diseases of theMFA and collum, as well as the relationship of individual microorganisms with the clinical manifestations of this pathology type and the detection of the pathogenetic role of immune disorders, allow to conduct studies on the formation of optimal correction schemes for each patient (personified) depending on the features of the course of the disease.

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Relationship between Campylobacter rectus and periodontal status during pregnancy

Abstract: These results indicate that C. rectus levels are higher in the oral flora of pregnant women and that this may be associated with increased salivary estradiol concentrations. This may contribute to periodontal disease progression during pregnancy.

Cited by 56 publications

References 35 publications

Detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women

Detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women

Porphyromonas gingivalisand adverse pregnancy outcome

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