Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia

Erkiliç, Ekin Emre; Erdoğan, Hidayet Metin; Öğün, Metin; Kırmızıgül, Ali Haydar; Kuru, Mushap; Kükürt, Abdulsamed

doi:10.14202/vetworld.2016.1238-1241

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…The increase of ROS causes cellular oxidative damage. In this case, inhibition of protein synthesis leads to occurrence of DNA damage and the formation of cellular death (7,13,23,27,28). In this study which was presented in parallel with results of Bozukluhan et al (5), TOC was higher (P < 0.001) and TAC was lower in FMD group compared to control group.…”

Section: Resultsmentioning

confidence: 99%

Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease

Deveci¹,

Kükürt²,

Nur³

et al. 2018

Medycyna Weterynaryjna

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The aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2–4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P<0.001) and HDL (P<0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P<0.001) compared to the healthy group. TOC was higher (P<0.001) and TAC was lower (P<0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection. .

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Section: Resultsmentioning

confidence: 99%

Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease

Deveci¹,

Kükürt²,

Nur³

et al. 2018

Medycyna Weterynaryjna

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“…As a result, the oxidative stress index increased. In many studies, it has been reported that oxidative stress occurs in diarrhea and septicemia that develops as a result [39][40][41]. When cells are exposed to oxidative stress, they increase the activity and expression of antioxidant enzymes to protect them from damage caused by free radicals [42].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

Akyüz¹

2021

Act Sci VetSci

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Diarrhea, which is one of the most important problems of cattle breeding in the world, is most common in calves in the neonatal period [1]. The neonatal period is used to define the 28 days following birth and is the period in which the most intense diseases and deaths occur in calves. Diseases occurring in calves during this period cause significant economic losses. These economic losses are the cost of treatment, loss of yield, and decrease in potential breeding stock, as well as newborn calf deaths [2][3][4]. It is known that many factors and factors play a role in the etiology of neonatal calf diarrhea. The most important of these are negative environmental factors, maternal reasons, unsuitable care/feeding conditions, and the calf's inability to receive colostrum. In addition, the main parasitic, viral, fungal, and bacterial agents among infectious agents constitute the source of neonatal diarrhea [5][6][7][8].Oxidative stress is defined as an imbalance between the number of antioxidants and reactive oxygen species or reactive nitrogen species in a biological system. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are byproducts of various cellular processes, including aerobic metabolism. For example, nitric oxide (NO•), which is an RNS, is produced from 1-arginine by nitric oxide synthase and then reacts with superoxide (O2•-) to form peroxynitrite (ONOO-) [9-12]. These reactive oxygen/nitrogen species (RONS), that is, hydroxyl, superoxide anion, nitric oxide, and nitrosyl anion molecules, are highly reactive due to their unpaired valence electrons [10]. Normally, RONS have involved in cell signaling (redox signaling) pathways, thiol switches, regulation of inflammatory cytokines, growth factors, etc. They have important biological roles in many cellular events such as [13].

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“…Hepcidin also helps host defense due to its direct antimicrobial properties (8,23). Erkilic et al (7), reported that serum hepcidin levels were very high in calves suspected of septicemia, and these levels decrease drastically after treatment. In our previous study on 56 cattle with single and dual infection (BHV-1, BVDV), hepcidin levels were compared.…”

Section: Discussionmentioning

confidence: 99%

Determination of serum amyloid A, haptoglobin and hepcidin levels in calves with endemic viral pneumonia

Dörtkardeş

Şahinduran

2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The aim of this study was to investigate serum amyloid A, haptoglobin and hepcidin levels in respiratory infections caused by various viral agents in calves. Pneumonia is an infectious or non-infectious disease affecting the lungs of all animals, and during the inflammation, blood levels of acute phase proteins increase rapidly. Hepcidin is a hormone that has many functions and is known as type II acute phase reactant. The blood samples were collected from a total of 20 calves to form the study group. The control group consisted of 10 healthy animals. Sera were analyzed with ELISA for antigen detection. According to the results, Bovine herpesvirus type-1 (BHV-1) was positive in 3 calves, Bovine viral diarrhea virus (BVDV) was positive in 3 calves, Bovine respiratory syncytial virus (BRSV) was positive in 1 calf, and Bovine parainfluenza virus type 3 (BPI3) was positive in 1 calf. Adenovirus infection was detected in 5 animals together with other viruses. Mixed infections were observed in 12 calves. Haptoglobin, serum amyloid A and hepcidin values were measured in sera. According to the results, statistically significant differences were observed between the two groups for the haptoglobin (P<0.01), serum amyloid A (P<0.05) and hepcidin (P<0.05). It was concluded that these parameters can be used to support the diagnosis of respiratory infections of the calves.

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Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia

Cited by 10 publications

References 19 publications

Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease

Serum paraoxonase activity and total sialic acid in sheep with foot and mouth disease

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

Determination of serum amyloid A, haptoglobin and hepcidin levels in calves with endemic viral pneumonia

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