Relationship between gene polymorphisms and prevalence of myocardial infarction among diabetic and non-diabetic subjects

Relvas, W.G.M.; Izar, Maria Cristina; Helfenstein, Tatiana; Fonseca, Miriam M.; Colovati, Mileny Esbravatti Stephano; Oliveira, Acary Sb; Ihara, Sílvia Saiuli Miki; Han, Sang Won; Casas, A.A. Las; Fonseca, Francisco Antônio Helfenstein

doi:10.1016/j.atherosclerosis.2004.05.025

Cited by 18 publications

(9 citation statements)

References 24 publications

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“…However, there were inconsistent results from numerous studies about the relationship between CETP genotype and HDL-C levels in diabetic patients. Two studies reported no association between TaqIB polymorphism and HDL-C concentration in patients with type 2 diabetes mellitus [27,33]. Kauma et al [34], however, found an association between TaqIB polymorphism and HDL-C in women, whereas Durlach et al [35] found that TaqIB polymorphism seems to exert a modulating role in men only.…”

Section: Discussionmentioning

confidence: 96%

Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Hsieh

Tien

Chang³

et al. 2007

Metabolism

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Section: Discussionmentioning

confidence: 96%

Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Hsieh

Tien

Chang³

et al. 2007

Metabolism

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“…Relvas et al [36] also found a higher prevalence of the B2B2 genotype of the CETP gene among diabetics than that observed in non-diabetics. These contradictory results indicate towards two possibilities.…”

Section: Discussionmentioning

confidence: 99%

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

2005

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BackgroundGenetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM). Goal of the present study was to determine the association of cholesteryl ester transfer protein TaqI B, D442G, and APOE Hha I polymorphisms with T2DM and its complications.MethodsStudy subjects were 136 patients and 264 healthy controls. All polymorphisms were detected using PCR-RFLP and statistical analysis done with χ2 test and ANOVA.ResultsAlthough CETP TaqI B polymorphism was not associated with the T2DM, yet B1B2 genotype was significantly (p = 0.028) associated with high risk of hypertension in diabetic patients (OR = 3.068, 95% CI 1.183–7.958). In North Indians D442G variation in CETP gene was found to be absent. Frequency of APOE HhaI polymorphism was also not different between patients and controls. In diabetic patients having neuropathy and retinopathy significantly different levels of total-cholesterol [(p = 0.001) and (p = 0.029) respectively] and LDL-cholesterol [(p = 0.001) and (p = 0.001) respectively] were observed when compared to patients with T2DM only. However, lipid levels did not show any correlation with the CETP TaqI B and APOE Hha I genetic polymorphisms.ConclusionCETP TaqI B and APOE HhaI polymorphism may not be associated with type II diabetes mellitus in North Indian population, however CETP TaqI B polymorphism may be associated with hypertension along with T2DM.

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“…One of these found no effect on MI risk, (14), whereas others found effects in the anticipated direction (increased HDL-c and decreased MI risk with the CETP Taq1B B2 allele) (15,16). The role of the CETP I405V variant is similarly unclear.…”

Section: Espite Considerable Progress In the Preventionmentioning

confidence: 90%

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

Isaacs¹,

Aulchenko²,

Hofman³

et al. 2007

The Journal of Clinical Endocrinology & Metabolism

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Relationship between gene polymorphisms and prevalence of myocardial infarction among diabetic and non-diabetic subjects

Cited by 18 publications

References 24 publications

Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

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