Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Hsieh, Ming‐Chia; Tien, Kai‐Jen; Chang, Shun‐Jen; Lo, Chao‐Sheng; Hsin, Shih-Chieh; Hsiao, Jeng-Yueh; Hsu, Shih‐Chieh; Liang, Huiting; Chen, Hung‐Chun; Shin, Shyi–Jang; Lin, Shiu‐Ru

doi:10.1016/j.metabol.2006.12.023

Cited by 14 publications

(22 citation statements)

References 43 publications

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“…Nevertheless, other studies did not detect such correlation, and some studies supported the hypothesis of a CETP effect independent of HDL-C levels. An association of CETP TaqIB gene polymorphism with CAD in a Taiwanese population with T2DM has been reported (Hsieh et al, 2007). Among the Turkish population, CETP TaqIB gene polymorphism was associated with the risk of CAD and lower HDL-C level in both patients with CAD and controls (Yilmaz …”

Section: Discussionmentioning

confidence: 99%

“…However, the results of a meta-analysis study (Boekholdt et al, 2005) indicated that the CETP TaqIB variant was associated with the risk of CAD, and this association was mediated by lower HDL-C levels. The study of Hsieh et al (2007) among Taiwanese patients with diabetes revealed that the B1B1 genotype of CETP is a predictor of CAD in these patients. They found that patients with diabetes with the CETP B1 allele (B1B1 and B1B2) had significantly lower serum HDL-C levels compared with those with the B2B2 genotype.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Cholesteryl Ester Transfer Protein TaqIB Variants and Risk of Coronary Artery Disease and Diabetes Mellitus in the Population of Western Iran

Rahimi

Negarandeh

Vaisi‐Raygani

et al. 2011

Genetic Testing and Molecular Biomarkers

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Cholesteryl Ester Transfer Protein TaqIB Variants and Risk of Coronary Artery Disease and Diabetes Mellitus in the Population of Western Iran

Rahimi

Negarandeh

Vaisi‐Raygani

et al. 2011

Genetic Testing and Molecular Biomarkers

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show abstract

“…The frequency of genotype B1B1 and allele B1 in the case group was significantly higher than that in control group. The HDL-C level in patients with allele B1 (B1B1 and B1B2) was lower than those without this allele (B2B2) (34). Some population-based studies have examined the relationship between TaqIB polymorphism and the risk of CAD in diabetic patients, but the reported results have been inconsistent (19,25,29).…”

Section: Acknowledgementsmentioning

confidence: 99%

Association of the CETP TaqIB Polymorphism with Coronary Artery Disease in Type 2 Diabetic Patients

et al. 2015

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Background and Objective: Diabetes mellitus is the most common risk factor for coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) TaqIB polymorphism is associated with changes in lipid profile and may be a risk factor for CAD in patients with diabetes. This study aimed to evaluate the association of CETP TaqIB polymorphism with CAD in patients with type 2 diabetes.Methods: In this case-control study, 292 diabetic patients were divided into two groups based on angiography reports (150 participants with normal angiogram as the control group and 142 participants with more than 50% stenosis of at least one coronary artery as the case group). The CETP TaqIB genotypes were determined by PCR-RFLP analysis. Fasting blood glucose was measured using glucose oxidase and lipid profile (triglycerides, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) by an enzymatic method.Results: There was no significant difference in the frequency of genotypes and alleles between case and control group (control group: B1B1, 17.3%; B1B2, 63.3%; and B2B2, 19.3%; case group: B1B1, 18.3%; B1B2, 64.1%; and B2B2, 17.6%) (P=0.92). In the control group, subjects with heterozygous genotype (B1B2 genotype) had higher levels of cholesterol compared with the other genotypes (B1B1 and B2B2 genotypes). Also, in the case group, subjects with B1B2 genotype had significantly higher weight (P=0.013).Conclusion: There is no significant correlation between CETP TaqIB polymorphism and the increased risk of coronary artery disease in patients with type 2 diabetes.

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“…Dyslipidemia is a recognized important risk factor for CHD. Previous studies (Hsieh et al, 2007;Tsujita et al, 2007;Kimura, 2009;Estévez-González et al, 2010) have demonstrated that the cholesterol ester transfer protein (CETP) plays a vital role in lipid metabolism. Expression of the CETP gene determines its function, thereby affecting lipid metabolism and CHD occurrence and development.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

Zhang

Xie

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary heart disease (CHD) group. Blood biochemical indices were determined using the enzyme method, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to study the TaqIB polymorphism of the CETP gene. The ACS and stable CHD groups were treated with atorvastatin, and blood lipid levels were reexamined after three months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) were all significantly higher in the ACS 2141 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 2140-2148 (2014) Coronary atherosclerotic heart disease and stable CHD groups compared to the control group (P < 0.05 or P < 0.01). After three months of treatment with atorvastatin, plasma levels of TC, LDL-C, triglycerides (TG) (only in patients with genotype B2B2), and lipoprotein(a) (only in patients with genotype B1B2) were all significantly decreased (P < 0.05 or P < 0.01). After treatment, the plasma level of TG was lower in patients with genotype B2B2 compared to patients with genotypes B1B1 or B1B2 (B1 carriers) (P < 0.01). Therefore, the CETP TaqIB polymorphism is associated with the lipid-lowering effect of atorvastatin in patients with CHD.

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Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

Cited by 14 publications

References 43 publications

Association Between Cholesteryl Ester Transfer Protein TaqIB Variants and Risk of Coronary Artery Disease and Diabetes Mellitus in the Population of Western Iran

Association Between Cholesteryl Ester Transfer Protein TaqIB Variants and Risk of Coronary Artery Disease and Diabetes Mellitus in the Population of Western Iran

Association of the CETP TaqIB Polymorphism with Coronary Artery Disease in Type 2 Diabetic Patients

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

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