Relationship between Fatty Liver and Pancreatitis

Jia, Jing; Wu, Qingming; Kou, Jiguang; Ming, Yang

doi:10.4236/ijcm.2018.94021

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…In individuals with fatty livers, a higher frequency of both local and systemic problems was seen. [7] Studies on the relationship between acute pancreatitis and fatty liver have produced conflicting results. Thus, the findings cannot be applied generally.…”

Section: Introductionmentioning

confidence: 99%

Fatty liver and acute pancreatitis severity: A prospective analysis utilizing computerized tomographic scan

Khan

Kashif

2023

ijhs

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Introduction: Fatty liver (FL) is often recognized in patients with acute pancreatitis (AP) and is frequently found in clinical practice because of substantial variables that put one at risk of complications. Aim: To evaluate the severity of acute pancreatitis in patients with and without fatty liver using CT severity index. Methodology: In this prospective study was carried out from June 2020 till December 2022. Liver and spleen mean attenuation values were examined using plain CT scans abdomen of patients with AP. Fatty liver was defined as a mean Hounsfield Unit (HU) liver/spleen) ratio < 1. Contrast-enhanced computed tomography (CECT) scan and CT Severity Index (CTSI) to grade the severity of AP. Analyzed information in SPSS. Degree of significance was determined using the chi-square test. Results: This study comprised of 100 Patients with AP (88 (88.0%) males and 32 (32.0%) female, mean age 34.68 12.762 years), 46 (46.0%) had FL and 54 (54.0%), without FL. Patients with FL experienced much worse pancreatitis than patients without FL. Acute edematous pancreatitis (39.4% vs. 60.6%) and acute necrotic collections (58.8% vs. 41.2%) were observed in patients with FL and without FL respectively. Conclusion: The severity of acute pancreatitis is significantly influe

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Section: Introductionmentioning

confidence: 99%

Fatty liver and acute pancreatitis severity: A prospective analysis utilizing computerized tomographic scan

Khan

Kashif

2023

ijhs

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Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis

Hoferica,

Borbély,

Aghdam

et al. 2024

Sci Rep

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Chronic liver diseases (CLD) affect 1.5 billion patients worldwide, with dramatically increasing incidence in recent decades. It has been hypothesized that the chronic hyperinflammation associated with CLD may increase the risk of a more severe course of acute pancreatitis (AP). This study aims to investigate the underlying impact of CLD on the outcomes of AP. A systematic search was conducted in Embase, Medline, and Central databases until October 2022. Studies investigating patients with acute pancreatitis and CLD, were included in the meta-analysis. A total of 14,963 articles were screened, of which 36 were eligible to be included. CLD was a risk factor for increased mortality with an odds ratio (OR) of 2.53 (CI 1.30 to 4.93, p = 0.01). Furthermore, renal, cardiac, and respiratory failures were more common in the CLD group, with ORs of 1.92 (CI 1.3 to 2.83, p = 0.01), 2.11 (CI 0.93 to 4.77, p = 0.062) and 1.99 (CI 1.08 to 3.65, p = 0.033), respectively. Moreover, the likelihood of developing Systemic Inflammatory Response Syndrome (SIRS) was significantly higher, with an OR of 1.95 (CI 1.03 to 3.68, p = 0.042). CLD is an important risk factor for worse outcomes in AP pancreatitis, leading to higher mortality and increased rates of local and systemic complications.

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Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Váncsa

Németh

Hegyi

et al. 2020

JCM

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The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care.

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Relationship between Fatty Liver and Pancreatitis

Cited by 4 publications

References 4 publications

Fatty liver and acute pancreatitis severity: A prospective analysis utilizing computerized tomographic scan

Fatty liver and acute pancreatitis severity: A prospective analysis utilizing computerized tomographic scan

Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis

Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis

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