Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential

Katayama, Naomi; Yamamoto, Masahide; Teranishi, Masaaki; Naganawa, Shinji; Nakata, Seiichi; Sone, Michihiko; Nakashima, Tsutomu

doi:10.3109/00016480903573187

Cited by 81 publications

(48 citation statements)

References 18 publications

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“…The clinical signiˆcance of MR imaging evaluation of endolymphatic hydrops has been reported mostly by intratympanic injection of GBCM, [7][8][9] and a scale for grading endolymphatic hydrops was proposed using 3D-FLAIR and 3D-inversion recovery with phase-sensitive reconstruction (3D-real IR) images obtained after intratympanic injection of GBCM. 4 Grading has also been applied to images obtained after double-and single-dose IV-GBCM.…”

Section: Discussionmentioning

confidence: 99%

Imaging of Endolymphatic and Perilymphatic Fluid after Intravenous Administration of Single-dose Gadodiamide

et al. 2012

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To visualize endolymph as bright signal after intravenous injection of single-dose gadodiamide, we shortened the inversion time of heavily T 2 -weighted 3-dimensional (3D) ‰uid-attenuated inversion recovery (FLAIR) to 2050 ms. In 14 patients with suspected M áeni àere's disease, we observed high signal of vestibular endolymph in all ears, including 6 ears without vestibular endolymphatic hydrops. We observed high signal of cochlear endolymph in 17 ears with cochlear endolymphatic hydrops but not 11 ears without cochlear endolymphatic hydrops.

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Section: Discussionmentioning

confidence: 99%

Imaging of Endolymphatic and Perilymphatic Fluid after Intravenous Administration of Single-dose Gadodiamide

et al. 2012

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“…Though the clinical signiˆcance of endolymphatic hydrops evaluation by MR imaging is reported, [3][4][5] the IT administration of GBCM is oŠ-label use, involves a slightly invasive puncture of the tympanic membrane, and requires 24 hours of waiting time before imaging. Thus, the development of a method for detecting endolymphatic hydrops by intravenous injection (IV) of GBCM was explored for wider use in the clinicalˆeld.…”

Section: Introductionmentioning

confidence: 99%

Imaging of M^|^eacute;ni^|^egrave;re's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Multiplication of MR Cisternography and HYDROPS Image

Naganawa

Yamazaki

Kawai

et al. 2013

MRMS

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A HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) image, created by subtracting a positive endolymph image from a positive perilymph image after intravenous injection of single-dose gadodiamide, has been reported to facilitate recognition of endolymphatic hydrops. To further increase the contrast-to-noise ratio (CNR) of HYDROPS images, we multiplied a T 2 -weighted MR cisternographic image onto the HYDROPS image. Ten patients with suspected M áeni àere's disease were included. The average CNR of generated images increased to more than 200 times that of HYDROP images.

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“…4 -7 Although the IT administration of GBCM is an off-label use and requires puncture of the tympanic membrane, various institutions have employed this method. [8][9][10][11][12][13][14] On the other hand, recent studies of the relationship between the degree of endolymphatic hydrops and patient symptoms have used the IV administration of single-dose GBCM (IV-SD-GBCM). [15][16][17] A previous study in volunteers set the time delay after IV-SD-GBCM at around 4 hours, 18 and a significant rise in perilymph signal beginning 1.5 hours after IV-SD-GBCM in volunteers has been reported.…”

Section: Introductionmentioning

confidence: 99%

Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

et al. 2014

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Purpose: We developed semi-quantitative methods to measure endolymphatic size on images obtained 4 hours after intravenous administration of single-dose gadolinium-based contrast medium (IV-SD-GBCM) and found little variation in results between observers. We used the methods to measure the size of the endolymph in healthy volunteers at various times after IV-SD-GBCM and attempted to determine the optimal timing for the evaluation.Methods: In 8 healthy male volunteers, we obtained heavily T 2 -weighted 3-dimensional fluid-attenuated inversion recovery (hT 2 W-3D-FLAIR) images 1.5, 3, 4.5, and 6 hours after IV-SD-GBCM as positive perilymph images (PPI) as well as acquiring positive endolymph images (PEI) and magnetic resonance cisternography (MRC). To evaluate the endolymph, we generated 2 kinds of processed images (HYDROPS-Mi2 and HY-DROPS2-Mi2) by subtracting PEI or MRC from PPI as previously proposed. We semiquantitatively measured the ratio of the area of the endolymph (%EL) to that of total lymph on the 2 kinds of generated images for the cochlea and vestibule according to the previously proposed method. We analyzed statistics to evaluate the change in %EL over time and used analysis of variance (ANOVA) for a 2 © 4 repeated-measures design to assess difference in image type. We adopted 5% as a significance level.Results: The %EL was significantly larger at 1.5 hours after IV-SD-GBCM than at 3, 4.5, and 6 hours in both the cochlea and vestibule for both kinds of generated images. Between 4.5 and 6 hours, the %EL plateaued for both the cochlea and vestibule, and the 2 kinds of generated images did not differ significantly.Conclusion: A delay of 1.5 hours after IV-SD-GBCM is not sufficient to evaluate endolymphatic size. The %EL plateaus between 4.5 and 6 hours. These data might be valuable for further clinical studies.

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Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential

Cited by 81 publications

References 18 publications

Imaging of Endolymphatic and Perilymphatic Fluid after Intravenous Administration of Single-dose Gadodiamide

Imaging of Endolymphatic and Perilymphatic Fluid after Intravenous Administration of Single-dose Gadodiamide

Imaging of M^|^eacute;ni^|^egrave;re's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Multiplication of MR Cisternography and HYDROPS Image

Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

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