Imaging of M^|^eacute;ni^|^egrave;re's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Multiplication of MR Cisternography and HYDROPS Image

Naganawa, Shinji; Yamazaki, Masahiro; Kawai, Hisashi; Bokura, Kiminori; Sone, Michihiko; Nakashima, Tsutomu

doi:10.2463/mrms.2012-0027

Cited by 50 publications

(50 citation statements)

References 11 publications

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“…11). 37,38,[101][102][103][104][105][106][107][108] In summary, 3D-FLAIR using VFA-TSE has several unique advantages for clinical neuroimaging as shown below: 1) Thinner slices and multi-planar reformation capability, 2) Higher flow sensitivity, 3) High sensitivity to subtle T 1 changes in fluid, 4) Free from CSF inflow artifacts, 5) Reasonable scan time, and 6) A 3D dataset that allows computer-aided analysis. Familiarity with these features of 3D-FLAIR imaging and proper use of 3D-FLAIR are important in order for radiologists to obtain useful information for patient management.…”

Section: Endolymphatic Hydropsmentioning

confidence: 99%

The Technical and Clinical Features of 3D-FLAIR in Neuroimaging

Naganawa

2015

magn reson med sci

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In clinical MR neuroimaging, 3D fluid-attenuated inversion recovery (3D-FLAIR) with a variable-flip-angle turbo spin echo sequence is becoming popular. There are more than 100 reports regarding 3D-FLAIR in the PubMed database. In this article, the technical and clinical features of 3D-FLAIR for neuroimaging are reviewed and summarized. 3D-FLAIR allows thinner slices with multi-planar reformation capability, a higher flow sensitivity, high sensitivity to subtle T 1 changes in fluid, images without cerebrospinal fluid (CSF) inflow artifacts, and a 3D dataset compatible with computer-aided analysis. In addition, 3D-FLAIR can be obtained within a clinically reasonable scan time. It is important for radiologists to be familiar with the features of 3D-FLAIR and to provide useful information for patients.

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Section: Endolymphatic Hydropsmentioning

confidence: 99%

The Technical and Clinical Features of 3D-FLAIR in Neuroimaging

Naganawa

2015

magn reson med sci

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“…24 The multiplication of heavily T 2 -weighted MRC and HYDROPS, which we have termed HYDROPS-Mi2, has been reported to increase the contrast-to-noise ratio (CNR) between the endolymph and perilymph. 21 HYDROPS-Mi2 images showed a more than 200-fold increase in CNR, and the background signal became quite uniform. MRC can be used as a "CNR booster."…”

Section: Discussionmentioning

confidence: 97%

“…All volunteers underwent heavily T 2 -weighted magnetic resonance cisternography (MRC) for anatomical reference of the fluid space and hT 2 W-3D-FLAIR (positive perilymph image: PPI) with inversion time of 2250 ms according to the clinical protocol of our hospital for evaluating endolymphatic hydrops. [19][20][21] We also obtained a positive endolymph image (PEI) with a shorter inversion time (TI) of 2050 ms. 22 We set parameters as previously reported. 22,23 hours after IV-SD-GBCM.…”

Section: Mr Imagingmentioning

confidence: 99%

“…21 We obtained a HYDROPS2-Mi2 (HYDROPS2 image Multiplied with heavily T 2 -weighted MR cisternography, Image #2 in the present study) image by multiplying the MRC and HYDROPS2. 20 Our aim in multiplying MRC onto HYDROPS and HYDROPS2 images was to set to zero the signal intensity value of bony structures possibly included in the ROI (i.e., osseous spiral lamina, interscalar septum, and bony wall of the labyrinth).…”

Section: Image Processingmentioning

confidence: 99%

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Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

et al. 2014

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Purpose: We developed semi-quantitative methods to measure endolymphatic size on images obtained 4 hours after intravenous administration of single-dose gadolinium-based contrast medium (IV-SD-GBCM) and found little variation in results between observers. We used the methods to measure the size of the endolymph in healthy volunteers at various times after IV-SD-GBCM and attempted to determine the optimal timing for the evaluation.Methods: In 8 healthy male volunteers, we obtained heavily T 2 -weighted 3-dimensional fluid-attenuated inversion recovery (hT 2 W-3D-FLAIR) images 1.5, 3, 4.5, and 6 hours after IV-SD-GBCM as positive perilymph images (PPI) as well as acquiring positive endolymph images (PEI) and magnetic resonance cisternography (MRC). To evaluate the endolymph, we generated 2 kinds of processed images (HYDROPS-Mi2 and HY-DROPS2-Mi2) by subtracting PEI or MRC from PPI as previously proposed. We semiquantitatively measured the ratio of the area of the endolymph (%EL) to that of total lymph on the 2 kinds of generated images for the cochlea and vestibule according to the previously proposed method. We analyzed statistics to evaluate the change in %EL over time and used analysis of variance (ANOVA) for a 2 © 4 repeated-measures design to assess difference in image type. We adopted 5% as a significance level.Results: The %EL was significantly larger at 1.5 hours after IV-SD-GBCM than at 3, 4.5, and 6 hours in both the cochlea and vestibule for both kinds of generated images. Between 4.5 and 6 hours, the %EL plateaued for both the cochlea and vestibule, and the 2 kinds of generated images did not differ significantly.Conclusion: A delay of 1.5 hours after IV-SD-GBCM is not sufficient to evaluate endolymphatic size. The %EL plateaus between 4.5 and 6 hours. These data might be valuable for further clinical studies.

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“…[3][4][5][6] The IT method usually provides higher contrast than the IV method and can predict the intralabyrinthine distribution of intratympanically injected gentamicin and steroids. 7,8 However, IT administration of GBCM is off-label use and requires puncture of the tympanic membrane.…”

Section: Introductionmentioning

confidence: 99%

MR Imaging of Ménière’s Disease after Combined Intratympanic and Intravenous Injection of Gadolinium using HYDROPS2

Naganawa¹,

Yamazaki²,

Kawai³

et al. 2014

MRMS

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Endolymphatic hydrops (EH) in Ménière's disease is currently evaluated by 3-dimensional (3D)-real inversion recovery (IR) sequence after intratympanic (IT) administration of gadolinium (Gd) or by heavily T 2 -weighted (hT 2 W)-3D-fluid-attenuated IR (FLAIR) sequence after intravenous (IV) injection of Gd. Unilateral IT injection is usually performed. We employed a method in which we simultaneously administered contrast into one ear intravenously (IV side) and into the other ear both intravenously and intratympanically (IT + IV side) to evaluate EH in 10 patients with Ménière's disease. We then compared a HYDROPS2 image obtained by subtracting magnetic resonance cisternography from hT 2 W-3D-FLAIR with an image obtained by 3D-real IR and found that we could evaluate EH in all ears on the HYDROPS2 image but only in the IT + IV side on the 3D-real IR image.

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Imaging of M^|^eacute;ni^|^egrave;re's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Multiplication of MR Cisternography and HYDROPS Image

Cited by 50 publications

References 11 publications

The Technical and Clinical Features of 3D-FLAIR in Neuroimaging

The Technical and Clinical Features of 3D-FLAIR in Neuroimaging

Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

MR Imaging of Ménière’s Disease after Combined Intratympanic and Intravenous Injection of Gadolinium using HYDROPS2

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