Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells

Boucret, Lisa; Barca, Juan Manuel Chao de la; Morinière, Catherine; Desquiret, Valérie; Ferré-L’Hôtellier, Véronique; Descamps, Philippe; Marcaillou, Charles; Reynier, Pascal; Procaccio, Vincent; May‐Panloup, Pascale

doi:10.1093/humrep/dev114

Cited by 114 publications

(73 citation statements)

References 74 publications

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“…In addition, taking into account that mitochondria become dysfunctional with aging, this might explain the increased rates of spindle and chromosomal abnormalities in the oocytes of aged women (Eichenlaub‐Ritter, ). In support of this, several reports with humans and animal models have provided evidence of mitochondrial dysfunction in poor quality oocytes (Van Blerkom et al, , ; Schon et al, ; Reynier et al, ; Tarín et al, ; May‐Panloup et al, ; El Shourbagy et al, ; Santos et al, ; Zhang et al, , ; Duran et al, ; Lee et al, ; Boucret et al, ). Mitochondrial alterations in these oocytes included organelle aggregation, reduced mtDNA copy number, mtDNA rearrangements, lower ΔΨm and impaired ATP production.…”

Section: Introductionmentioning

confidence: 80%

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Chiaratti

Garcia

Carvalho

et al. 2018

Cell Biology International

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Mitochondria play a fundamental role during development of the female germline. They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA-mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late-onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication/transmission of non-deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA-encoded diseases.

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Section: Introductionmentioning

confidence: 80%

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Chiaratti

Garcia

Carvalho

et al. 2018

Cell Biology International

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“…Mitochondria in oocytes or CCs participated in oocyte maturation, fertilization, embryo development and pregnancy outcomes 26, 42-44. Increased abnormal mitochondrial structure and decreased expression of mitochondrial genes were observed in human unfertilized oocytes 45, 46.…”

Section: Discussionmentioning

confidence: 99%

“…The mtDNA content in oocytes was pivotal to fertilization and served as a predictor for oocyte quality 26, 27. Moreover, Boucret et al concluded that mitochondrial biogenesis of the CCs may be a major determinant of oocyte competence 42. The study conducted by Ogino et al demonstrated that mtDNA copy number in CCs can be used to predict embryo quality 43.…”

Section: Discussionmentioning

confidence: 99%

The Application of Dehydroepiandrosterone on Improving Mitochondrial Function and Reducing Apoptosis of Cumulus Cells in Poor Ovarian Responders

Lin¹,

Wang²,

Wen³

et al. 2017

Int. J. Med. Sci.

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Poor ovarian responders (PORs) pose a great challenge for in vitro fertilization (IVF). Previous studies have suggested that dehydroepiandrosterone (DHEA) may improve IVF outcomes in PORs. The current study attempted to investigate the clinical benefits of DHEA in PORs and the possible mechanisms of DHEA on cumulus cells (CCs). This was a prospective study performed at one tertiary center from January 2015 to March 2016. A total of 131 women who underwent IVF treatment participated, including 59 normal ovarian responders (NORs) and 72 PORs. PORs were assigned to receive DHEA supplementation or not before the IVF cycle. For all patients, CCs were obtained after oocyte retrieval. In the CCs, mRNA expression of apoptosis-related genes and mitochondrial transcription factor A (TFAM) gene, terminal deoxynucleotidyl transferase dUTP nick end labeling assay, mitochondrial dehydrogenase activity and mitochondrial mass were measured. The results indicated that PORs with DHEA supplementation produces a great number of top-quality embryos at day 3 and increased the number of transferred embryos and fertilization rate compared with those without DHEA supplementation. Additionally, supplementation with DHEA in PORs decreased DNA damage and apoptosis in CCs while enhancing the mitochondrial mass, mitochondrial dehydrogenase activity and TFAM expression in CCs. In conclusion, our results showed that the benefits of DHEA supplementation on IVF outcomes in PORs were significant, and the effects may be partially mediated by improving mitochondrial function and reducing apoptosis in CCs.

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“…The identification of surrogate markers of oocyte competence and favorable reproductive outcomes in assisted reproductive technology is a goal of many transcriptome, proteome, and metabolome studies. The analysis of granulosa and cumulus cells is considered one of the best noninvasive strategies available today …”

Section: Factors Influencing Oocyte Qualitymentioning

confidence: 99%

Updating the markers for oocyte quality evaluation: intracellular temperature as a new index

Hoshino

2018

Reprod Medicine & Biology

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BackgroundThe developmental competence of an embryo is principally dictated by the oocyte. Usually, oocyte selection is based on morphological properties; however, all morphological criteria that are currently used for the grading and screening of oocytes are not able to eliminate the subjectivity. Despite recent studies of the molecular factors related to oocyte quality, it is technically difficult to develop an index based on these factors, and new indices that reflect intracellular conditions are necessary.MethodsMorphological and molecular factors influencing developmental competence were comprehensively reviewed, and intracellular temperature was evaluated as a new marker of oocyte quality.Main findingsThe intracellular temperature of mature oocytes was high in fresh oocytes and decreased with time after polar body release. Under the same conditions, the intracellular temperature and its distribution differed among oocytes, suggesting that temperature represents the state of each oocyte.ConclusionIntracellular temperature is advantageous as an objective and quantitative indicator of oocyte quality. Further studies should evaluate the link between temperature and cellular phenomena to establish its use as an indicator of quality.

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Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells

Cited by 114 publications

References 74 publications

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

The Application of Dehydroepiandrosterone on Improving Mitochondrial Function and Reducing Apoptosis of Cumulus Cells in Poor Ovarian Responders

Updating the markers for oocyte quality evaluation: intracellular temperature as a new index

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