Relationship Between Cumulative Adverse Childhood Experiences and Myocardial Infarction in Adulthood: a Systematic Review and Meta-analysis

Jacquet-Smailovic, Murielle; Brennstuhl, Marie-Jo; Tarquinio, Camille; Tarquinio, Cyril

doi:10.1007/s40653-021-00404-7

Cited by 9 publications

(8 citation statements)

References 27 publications

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“…Adverse childhood events 48 , 52 , 53 , 102 , 103 , 104 , 105 , 106 : Adverse childhood events were associated with a higher risk of later‐life composite CVD, 53 , 102 , 103 , 104 , 106 coronary heart disease, 102 heart failure, 102 myocardial infarction, 105 and ischemic heart disease. 48 , 52 , 53 , 106 However, they had an inconsistent association with stroke.…”

Section: Resultsmentioning

confidence: 99%

The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review

Teshale

Htun

Owen

et al. 2023

JAHA

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Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Addressing social determinants of health (SDoH) may be the next forefront of reducing the enormous burden of CVD. SDoH can be defined as any social, economic, or environmental factor that influences a health outcome. Comprehensive evidence of the role of SDoH in CVD is lacking, nevertheless. This umbrella review aims to give a comprehensive overview of the role of SDoH in CVD. We searched systematic reviews (with or without meta‐analyses) using 8 databases and included review reference lists. Four themes (economic circumstances, social/community context, early childhood development, and neighbourhood/built environment) and health literacy in the health/health care theme were considered. Seventy reviews were eligible. Despite the quality of the included reviews being low or critically low, there was consistent evidence that factors relating to economic circumstances and early childhood development themes were associated with an increased risk of CVD and CVD mortality. We also found evidence that factors in the social/community context and neighbourhood/built environment themes, such as social isolation, fewer social roles, loneliness, discrimination, ethnicity, neighborhood socioeconomic status, violence, and environmental attributes, had a role in CVD. SDoH factors without (or with minimal) evidence synthesis for CVD were also identified. In sum, this umbrella review offers evidence that SDoH, especially economic circumstance and early childhood development, play a significant role in CVD. This calls for the strengthening of nonmedical interventions that address multiple factors simultaneously and the inclusion of SDoH in future CVD risk prediction models. Registration URL: https://www.crd.york.ac.uk/prospero/ ; Unique identifier: CRD42022346994.

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Section: Resultsmentioning

confidence: 99%

The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review

Teshale

Htun

Owen

et al. 2023

JAHA

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“…Using the previous review by Jacquet-Smailovic et al (2021) , covariates were selected to include variables that mediate mechanisms between ACEs and CVD outcomes. These are depressive disorder (yes/no), diabetes (yes/no), obesity (yes/no), physical activity (yes/no), heavy alcohol consumption (yes/no), and smoking status (current smoker, every day; current smoker, some days; former smoker; or never smoked).…”

Section: Methodsmentioning

confidence: 99%

“…Since then, other studies have replicated this finding. One systematic review with meta-analysis showed that cumulative ACEs increased the risk of myocardial infarction in adulthood after controlling for CVDs and psychosocial factors ( Jacquet-Smailovic et al, 2021 ). In a meta-analysis by Hughes et al (2017) , individuals with four or more ACEs had higher risks of developing CVD when compared to individuals with no ACEs.…”

Section: Introductionmentioning

confidence: 99%

“…In the current study, the age of individuals was restricted to 55 years or older as the “young-old” (first developmental epoch in later life) begins at age 55, consistent with the age cut in the literature ( Jeuring et al, 2019 ; Klokgieters et al, 2019 ; Suanet et al, 2009 ). This cut-off age has also been utilized in life-span research to examine the roles of adversity and trauma in populations' later health ( Yang & Hedeker, 2020 ), including cardiovascular conditions ( Jacquet-Smailovic et al, 2021 ). Furthermore, one study demonstrated that age screening using a cut-off of 55 years can detect 86.0% of all first CVD events arising in the population, which makes this cut-off a meaningful value for the current study's participants ( Wald et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

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Network analysis of adverse childhood experiences and cardiovascular diseases

Lee

Cao

Eagen-Torkko

et al. 2023

SSM - Population Health

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“…Systematic reviews and meta-analyses of prospective studies have revealed associations between psychosocial stress and an increased risk of incident ASCVD (►Table 2), 28,[56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74] as well as poor prognosis in established ASCVD (►Table 3) 69, [75][76][77][78][79][80][81][82] ; both scenarios being complicated by atherothrombotic events. This literature is primarily concerned with psychosocial risk factors of coronary heart disease (CHD), followed by cerebrovascular disease and peripheral artery disease (PAD).…”

Section: Stress As a Risk Factor For Thrombotic Disease Evidence From...mentioning

confidence: 99%

Stress-Induced Hypercoagulability: Insights from Epidemiological and Mechanistic Studies, and Clinical Integration

von Känel

2024

Semin Thromb Hemost

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By integrating findings from comprehensive reviews, meta-analyses, and cutting-edge genetic studies, this article illuminates the significance of stress-induced hypercoagulability in clinical medicine. In particular, the findings from numerous prospective cohort studies indicate that stress and hemostatic factors of a hypercoagulable state are associated with increased incident risk and poor prognosis for atherosclerotic cardiovascular disease and venous thromboembolism. Mendelian randomization studies suggest that these associations are partially causal. The review synthesizes extensive research on the link between acute and chronic stress and hypercoagulability, outlining a potential pathway from stress to thrombosis risk. Consistent with the allostatic load concept, acute stress-induced hypercoagulability, initially adaptive, can turn maladaptive under chronic stress or excessive acute stress, leading to arterial or venous thrombotic events. Individuals with predisposing factors, including atherosclerosis, thrombophilia, or immobilization, may exhibit an increased risk of thrombotic disease during stress. Contextual sociodemographic characteristics, the stress experience, and coping resources additionally modulate the extent of stress-induced hypercoagulability. Research into the neuroendocrine, cellular, and molecular bases reveals how stress influences platelet activation coagulation and fibrinolysis. The activation of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis, along with vagal withdrawal, and the effects of catecholamines, cortisol, and vasopressin, are the central mechanisms involved. Hemoconcentration, inflammation, endothelial dysfunction, and thrombopoiesis additionally contribute to stress-induced hypercoagulability. Further research is needed to prove a causal link between chronic stress and hypercoagulability. This includes exploring its implications for the prevention and management of thrombotic diseases in stressed individuals, with a focus on developing effective psychosocial and pharmacological interventions.

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Relationship Between Cumulative Adverse Childhood Experiences and Myocardial Infarction in Adulthood: a Systematic Review and Meta-analysis

Cited by 9 publications

References 27 publications

The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review

The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review

Network analysis of adverse childhood experiences and cardiovascular diseases

Stress-Induced Hypercoagulability: Insights from Epidemiological and Mechanistic Studies, and Clinical Integration

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