Network analysis of adverse childhood experiences and cardiovascular diseases

Lee, Chiyoung; Cao, Jiepin; Eagen-Torkko, Meghan; Mohammed, Selina A.

doi:10.1016/j.ssmph.2023.101358

Cited by 5 publications

(2 citation statements)

References 71 publications

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“…For men, an increased risk was observed only following chronic illness in a relative ( 10 ). Stoke was most strongly associated with physical abuse in women and household incarceration in men ( 20 ).…”

Section: Ela and Cardiovascular Outcomes In Humansmentioning

confidence: 99%

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

Tan,

Zhou,

Chen

et al. 2024

Front. Public Health

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Strong epidemiological evidence has shown that early life adversity (ELA) has a profound negative impact on health in adulthood, including an increased risk of cardiovascular disease, the leading cause of death worldwide. Here, we review cohort studies on the effects of ELA on cardiovascular outcomes and the possible underlying mechanisms. In addition, we summarize relevant studies in rodent models of ELA. This review reveals that the prevalence of ELA varies between regions, time periods, and sexes. ELA increases cardiovascular health risk behaviors, susceptibility to mental illnesses, and neuroendocrine and immune system dysfunction in humans. Rodent models of ELA have been developed and show similar cardiovascular outcomes to those in humans but cannot fully replicate all ELA subtypes. Therefore, combining cohort and rodent studies to further investigate the mechanisms underlying the association between ELA and cardiovascular diseases may be a feasible future research strategy.

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Section: Ela and Cardiovascular Outcomes In Humansmentioning

confidence: 99%

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

Tan,

Zhou,

Chen

et al. 2024

Front. Public Health

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“…However, it is a versatile statistical method that can leverage multivariate data involving factors at varying levels. Network models have been used recently in health disparities research to include different components of adverse childhood experiences (ACEs) and multiple mental health conditions in adulthood simultaneously in order to elucidate the complex one‐to‐one inter‐relationships (Breuer et al, 2020; Isvoranu et al, 2016; Lee et al, 2023; Schouw et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The application of clique percolation method in health disparities research

Lee

Cao

González-Guarda

2023

Journal of Advanced Nursing

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AimsClique percolation, one of the joint community detection algorithms in network science, is a novel and efficient approach to detecting overlapping communities in real networks. The current study illustrated how clique percolation can help to identify overlapping communities within the complex networks underlying health disparities, particularly highlighting nodes with strong associations with more than one community.DesignA cross‐sectional study.MethodsThe study used a dataset on Latinx populations (N = 1654; mean age = 43.3 years; 53.1% women) as an example to demonstrate the role of such overlapping nodes in the network of syndemic conditions and their common risk factors. Syndemic conditions in the network included HIV risk, substance abuse (smoking, heavy alcohol consumption and marijuana use) and poor mental health. Moreover, the risk factors encompassed individual (education and income) and sociostructural (adverse childhood experiences [ACEs] and access to services) factors. The network was estimated using the R‐package bootnet. Clique percolation was conducted on the estimated network using the R‐package CliquePercolation.ResultsA total of three communities were detected, with HIV risk and poor mental health not being assigned to any community. In general, Community 1 was comprised of ACE categories, Community 2 included education, income and access to services and Community 3 included other syndemic conditions. Of note, two nodes were assigned to two communities: ‘household dysfunction’ to Communities 1 and 2 and ‘smoking’ to Communities 2 and 3.ConclusionHousehold dysfunction might be the key connector, among other ACEs, to individual and structural barriers. Such barriers further exposed Latinx individuals to risky behaviours, especially smoking, which further linked to marijuana use and heavy alcohol consumption.ImpactClique percolation facilitated our understanding of the complex systems of factors shaping health disparities. The overlapping nodes are promising intervention targets for reducing health disparities in this historically marginalized population.Patient or Public ContributionNo patient or public contribution.

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Contributions of Violence Exposure and Traumatic Stress Symptoms to Physical Health Outcomes in Incarcerated Adolescents

Perkins,

Ametrano,

Leach

et al. 2024

Youth & Society

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Violence and traumatic stress negatively affect physical health in youth. Incarcerated adolescents have high rates of violence exposure and health problems, however, few studies have examined medical records and violence exposure in this high-risk population. Self-reported violence exposure and symptoms of stress were collected in 115 incarcerated male adolescents. Medical charts were reviewed for the presence of somatic complaints and chronic health conditions. Regression modeling and odds ratios demonstrated that exposure to intimate partner violence (IPV), child abuse, and sexual abuse predicted specific health conditions. The hierarchical regression model established that traumatic stress and a history of sexual abuse predict cumulative health problems. The study demonstrates that early exposure to violence combined with the presence of traumatic stress symptoms increases the risk for later health problems and can be used by healthcare providers to identify youth at increased risk of long-term health outcomes in high-risk populations.

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Network analysis of adverse childhood experiences and cardiovascular diseases

Cited by 5 publications

References 71 publications

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

The application of clique percolation method in health disparities research

Contributions of Violence Exposure and Traumatic Stress Symptoms to Physical Health Outcomes in Incarcerated Adolescents

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