Relationship Between Cardiovascular Events and Serum Lipid and Plasma Fatty Acid Profile in Maintenance Hemodialysis Patients With Diabetic Mellitus

Nakamura, Norio; Osawa, Hiroshi; Nagawa, Daiki; Nakata, Michi; Narita-Kinjo, Ikuyo; Fujita, Takeshi; Murakami, Reiichi; Shimada, Michiko; Tomita, Hirofumi; Tsutaya, Chikako; Saito, Hisao; Suzuki, Tadashi

doi:10.21873/invivo.13193

Cited by 3 publications

(8 citation statements)

References 18 publications

(14 reference statements)

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“…In contrast, the concentration of unsaturated fatty acids in CKD patients with or without dialysis decreased compared with healthy people Table 2, especially omega 3 and omega 6. This is consistent with published worldwide reports [2,11]. The general decrease in unsaturated fatty acids compared with the control group in parallel with the decrease in triglycerides may be due to malnutrition, inflammation, and atherosclerosis.…”

Section: Discussionsupporting

confidence: 93%

“…The rate of dyslipidemia of patients with chronic kidney disease on dialysis in our study was high, the in TG accounted for the highest rate, then the increase in LDL-C and increase in TC, HDL-C accounted for a lower percentage. Controlling dyslipidemia to reduce the risk of cardiovascular disease is an important goal for this population [2,5].…”

Section: Discussionmentioning

confidence: 99%

“…EPA is both a precursor and the hydrolytic breakdown product of eicosapentaenoic ethanol amide. A prescription drug containing only EPA was shown to reduce heart attack, stroke, and cardiovascular death by 25% relative to a placebo in those with statin-resistant hypertriglyceridemia [2].…”

mentioning

confidence: 99%

“…Plasma concentrations of saturated fatty acids in CKD patients decreased compared with healthy subjects. [2]. Observational and interventional studies have shown an association of omega 3/omega 6 concentration and ratio with dialysis time [4,7].…”

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confidence: 99%

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Plasma Polyunsaturated Fatty Acid Levels in Patients with Chronic Kidney Disease on Dialysis

Pham

2022

AJBSR

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Chronic kidney disease (CKD) has become a public health problem in many countries. Worldwide, more than 500 million people are suffering from CKD, of which the majority (80%) come from developing countries [1]. In Vietnam, it is estimated that about 10,000 patients receive CKD. Patients with CKD on long-term dialysis often experience many complications related to anemia, bone dystrophy, cardiovascular disease, and malnutrition.The 20-carbon unsaturated fatty acids are essential fatty acids that the body cannot synthesize on its own, a deficiency will lead to imbalances, autoimmune disorders, inflammatory conditions.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Plasma Polyunsaturated Fatty Acid Levels in Patients with Chronic Kidney Disease on Dialysis

Pham

2022

AJBSR

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“…This study was registered at University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR, study number UMIN000036598). Recently, we reported the relationship between CV events and serum lipid and plasma fatty acid profile among patients with diabetes in this study (14).…”

Section: Methodsmentioning

confidence: 75%

Role of High-sensitivity C-reactive Protein in Future Cardiovascular Events in Hemodialysis Patients

OSAWA,

NAKAMURA,

TSUTAYA

et al. 2024

In Vivo

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Background/Aim: The pathogenesis of cardiovascular disease (CVD) in hemodialysis (HD) patients involves inflammation and oxidative stress. High-sensitivity C-reactive protein (hs-CRP) is an established inflammatory biomarker associated with CVD. Several studies have suggested that the inflammatory biomarker pentraxin-3 (PTX-3) and the oxidative stress-related biomarker soluble lectinlike low-density lipoprotein receptor-1 (sLOX-1) are novel biomarkers for CVD in non-HD populations. This study aimed to clarify the association of these established and novel biomarkers with future cardiovascular (CV) events in HD patients. Patients and Methods: This was a single-center prospective cohort study that included 255 HD patients. The primary outcome was the composite of nonfatal and fatal CV events. The event-free survival rate between the two groups according to the median plasma level of each biomarker at baseline was evaluated using the Kaplan-Meier method. The risk for CV events at elevated levels of each biomarker was estimated using Cox proportional hazard model. Results: We observed 44 CV events during the median follow-up period of 743 days. The event-free survival rate significantly differed between the two groups in hs-CRP but not in PTX-3 or sLOX-1. The unadjusted hazard ratio (HR) for CV events in patients with hs-CRP levels above the median was 2.63 [95% confidence interval (CI)=1.37-5.02]. The HR remained significant after adjusting for age, sex, history of CVD, and diabetes (HR=2.30;. Conclusion: In HD patients, hs-CRP may have a predictable role for future CV events, whereas PTX-3 and sLOX-1 do not.Patients on hemodialysis (HD) have a high risk for morbidity and mortality due to cardiovascular disease (CVD) (1). Biomarkers that may predict future cardiovascular (CV) events may allow for the early recognition of high-risk patients and increase opportunities for appropriate therapy, improving their prognosis. Inflammation and oxidative stress are involved in the pathophysiology of CVD in patients on HD (2). Thus, biomarkers that reflect inflammation and oxidative stress may serve as predictors of future CV events in patients on HD.High-sensitivity C-reactive protein (hs-CRP) is an established inflammatory biomarker, with elevated levels predicting CV events in the general population (3, 4). Although increased levels of hs-CRP are associated with allcause or CV mortality in patients on HD (5, 6), its relationship with future CV events remains unknown. Pentraxin-3 (PTX-3) is an acute phase reactant belonging to the PTX superfamily, in which CRP belongs to, but its cellular source and regulation of production are different from those of CRP (7). PTX-3 may be closely associated with 1351

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Significance of serum NLRP3 as a potential predictor of 5-year death in hemodialysis patients: A prospective observational cohort study

Jiang,

Xu,

Wang

et al. 2024

Medicine

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Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is involved in inflammatory response. This study was done to explore the role of serum NLRP3 as a predictive biomarker of death after hemodialysis. In this prospective observational study of 331 patients undergoing maintenance hemodialysis, serum NLRP3 levels were measured. Univariate analysis and multivariate analysis were sequentially performed to determine predictors of 5-year death after hemodialysis. Age, major adverse cardiac and cerebral events (MACCE), and serum NLRP3 levels independently predicted 5-year mortality and overall survival (all P < .05). No interactions were found between serum NLRP3 levels and other variables, such as age, gender, hypertension, diabetes mellitus, primary renal diseases, and MACCE (all P interaction > .05). Serum NLRP3 levels were linearly correlated with risk of death and overall survival under restricted cubic spline (both P > .05) and substantially discriminated patients at risk of death under receiver operating characteristic curve (P < .001). Two models, in which age, MACCE, and serum NLRP3 were combined, were built to predict 5-year mortality and overall survival. The mortality prediction model had significantly higher predictive ability than age, AMCCE, and serum NLRP3 alone under receiver operating characteristic curve (all P < .05). The models, which were graphically represented by nomograms, performed well under calibration curve and decision curve. Serum NLRP3 levels are independently related to 5-year mortality and overall survival of patients after hemodialysis, suggesting that serum NLRP3 may be a potential prognostic biomarker of hemodialysis patients.

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Relationship Between Cardiovascular Events and Serum Lipid and Plasma Fatty Acid Profile in Maintenance Hemodialysis Patients With Diabetic Mellitus

Cited by 3 publications

References 18 publications

Plasma Polyunsaturated Fatty Acid Levels in Patients with Chronic Kidney Disease on Dialysis

Plasma Polyunsaturated Fatty Acid Levels in Patients with Chronic Kidney Disease on Dialysis

Role of High-sensitivity C-reactive Protein in Future Cardiovascular Events in Hemodialysis Patients

Significance of serum NLRP3 as a potential predictor of 5-year death in hemodialysis patients: A prospective observational cohort study

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