Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Chang, Tsu‐Chung; Zheng, Cai Mei; Wu, Mei Yi; Chen, Tzu Ting; Wu, Yungang; Wu, Yi; Lin, Hsin Ting; Zheng, Jun; Chu, Nain-Feng; Lin, Yanwei; Su, Sui-Lung; Lu, Kuo Cheng; Chen, Jin Shuen; Sung, Fung Chang; Lee, Chien Te; Yang, Yu; Hwang, Shang Jyh; Wang, Ming Cheng; Hsu, Yung Ho; Chiou, Hung Yi; Kao, Senyeong; Lin, Yuh Feng

doi:10.1038/s41598-018-24757-6

Cited by 32 publications

(33 citation statements)

References 56 publications

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“… 49 , 50 , 51 , 52 , 53 , 54 Studies from China and Taiwan, for example, have found that low BMI is an independent risk factor for disease progression in individuals with CKD. 49 , 50 In the United States and Sweden, higher BMI has been commonly associated with CKD progression, but at least one large cohort study has shown U-shaped associations between BMI and CKD progression and mortality. 22 , 51 , 52 , 53 , 54 …”

Section: Discussionmentioning

confidence: 99%

Population Estimates of GFR and Risk Factors for CKD in Guatemala

Miller

Tuiz²,

Shaw³

et al. 2021

Kidney International Reports

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Introduction Chronic kidney disease (CKD) is an emerging public health priority in Central America. However, data on the prevalence of CKD in Guatemala, Central America’s most populous country, are limited, especially for rural communities. Methods We conducted a population-representative survey of 2 rural agricultural municipalities in Guatemala. We collected anthropometric data, blood pressure, serum and urine creatinine, glycosylated hemoglobin, and urine albumin. Sociodemographic, health, and exposure data were self-reported. Results We enrolled 807 individuals (63% of all eligible, 35% male, mean age 39.5 years). An estimated 4.0% (95% confidence interval [CI] 2.4–6.6) had CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min per 1.73 m 2 . Most individuals with an eGFR below 60 ml/min per 1.73 m 2 had diabetes or hypertension. In multivariable analysis, the important factors associated with risk for an eGFR less than 60 ml/min per 1.73 m 2 included a history of diabetes or hypertension (adjusted odds ratio [aOR] 11.21; 95% CI 3.28–38.24), underweight (body mass index [BMI] <18.5) (aOR 21.09; 95% CI 2.05–217.0), and an interaction between sugar cane agriculture and poverty (aOR 1.10; 95% CI 1.01–1.19). Conclusions In this population-based survey, most observed CKD was associated with diabetes and hypertension. These results emphasize the urgent public health need to address the emerging epidemic of diabetes, hypertension, and CKD in rural Guatemala. In addition, the association between CKD and sugar cane in individuals living in poverty provides some circumstantial evidence for existence of CKD of unknown etiology in the study communities, which requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Population Estimates of GFR and Risk Factors for CKD in Guatemala

Miller

Tuiz²,

Shaw³

et al. 2021

Kidney International Reports

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“…Epidemiological studies have demonstrated that obesity, a family history of ESRD and high body mass index (BMI) are an essential risk factors for incident CKD and increased risk of ESRD (11,12), and associated with an increased risk of CKD development among adult individuals in the general population (13).…”

Section: Introductionmentioning

confidence: 99%

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Elemam

2019

SJMS

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Background: Previously, it has been demonstrated that obesity is one of the strongest risk factors for incident chronic kidney diseases (CKDs). Currently, we examine the association between Body mass index (BMI) and CKD in first degree relatives (FDRs) of renal failure patients on hemodialysis. Materials and methods: In a cross-sectional study, 135 FDRs of end-stage renal disease (ESRD) patients on hemodialysis were included. Serum creatinine, uric acid, calcium, phosphate, and alkaline phosphatase were measured. Glomerular filtration rate (e-GFR) and albumin to creatinine ratio (ACR) were estimated. The height in Cm, weight in Kg was measured, and the BMI was calculated. Results: Females 64% were found to have a higher frequency than males 36%. The frequency of BMI categories was found to be 26.7% obese, 26.7% overweight, and 46.6. % normal weight. The mean BMI was (26.0 ± 6.62). The prevalence of CKDs is 19.3% among relatives. CKDs were more frequent 42.3 % in obese, followed by 30.8 % in overweight and 26.9% in normal-weight relatives. Obese and overweight relatives have significantly higher ACR than normal weight (P= 0.012). GFR found to be significantly higher in obese and overweight relatives than normal weight (P = 0.000). GFR was negatively correlated with BMI (R = - 0.430, P = 0.000). Conclusion: Obese and overweight RF relatives had higher ACR and lower eGFR. Therefore, obese and overweight members are at higher risk of developing CKD. Keywords: CKDs, Family members, BMI, Obesity, ACR, eGFR. Corresponding author: Abozaid Mohammed Hamid, email: elemam69@hotmail.com

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“…In addition to overweight, underweight was also signi cantly associated with increased risk of CKD. Several studies showed that Patients with BMI < 18.5 kg/m 2 exhibited non-signi cantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups [33]. It reminds us that CKD is a complex disease that requires individualized nutritional intervention to its treatment.…”

Section: Discussionmentioning

confidence: 97%

Epidemiology of Chronic Kidney Disease and Associated Metabolic Risk Factors in an Old Chinese Population

Xu¹,

Liu²,

He³

et al. 2020

Preprint

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Chronic kidney disease (CKD) has become a worldwide health problem among aging populations. However, epidemiological information on Chinese elderly people with CKD is still lacking. This study aimed to investigate the epidemiological features and associated risk factors of CKD in aging population in China. In this cross-sectional study, a total of 37,533 individuals aged ≥65 years were enrolled in Binhai from January to December 2018. The crude and standardized prevalence of CKD were calculated. Associations of metabolism-related indicators with CKD were examined using univariate and multivariate analysis. The overall prevalence of CKD was 17.7% (95% confidence interval [CI], 17.3%-18.1%) in this Chinese elderly population. The prevalence was 17.5% among men (95% CI, 17.0%-18.1%) and 17.8% among women (95% CI, 17.3 -18.4%). The mean eGFR was 84.22 (SD ± 12.87) mL/min/1.73 m2, with the median value higher for women than for men. Aging, pre-HTN, HTN, elevated triglyceride and FBG were found to be independent risk factors for CKD. Our study shows a high prevalence of CKD among Chinese elderly population. Aging, pre-HTN, HTN, elevated triglyceride and FBG were all independent risk factors associated with CKD. More attention should be paid to metabolic diseases to prevent CKD in the elderly.

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Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Cited by 32 publications

References 56 publications

Population Estimates of GFR and Risk Factors for CKD in Guatemala

Population Estimates of GFR and Risk Factors for CKD in Guatemala

Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study

Epidemiology of Chronic Kidney Disease and Associated Metabolic Risk Factors in an Old Chinese Population

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